Abnormal circulation in solid tumors results in hypoxia, which modulates both tumor intrinsic malignant properties as well as anti-tumor immune responses. Given the importance of hypoxia in glioblastoma (GBM) biology and particularly in shaping anti-tumor immunity, we analyzed which immunomodulatory genes are differentially regulated in response to hypoxia in GBM cells. Gene expression analyses ...

The flowering phenology of early-blooming plants is largely determined by snowmelt timing in high-latitude and high-altitude ecosystems. When the synchrony of flowering and pollinator emergence is disturbed by climate change, seed production may be restricted due to insufficient pollination success. We revealed the mechanism of phenological mismatch between a spring ephemeral (<i>Corydalis ambigua</i>) ...

<i>Background</i> - General knowledge on climate change effects and adaptation strategies has increased significantly in recent years. However, there is still a substantial information gap regarding the influence of climate change on infectious diseases and how these diseases should be identified. From a One Health perspective, zoonotic infections are of particular concern. The climate in Northern ...

Current research on tourism in the Arctic has focused largely on the extent, location, and type of tourism activities that occur in the region. Recently, challenges have been identified that the tourism industry is likely to face in the wake of global changes, including climate change. Related research, conducted within and outside of the Arctic, suggests that rural communities can become economically ...

Invertebrate herbivores depend on external temperature for growth and metabolism. Continued warming in tundra ecosystems is proposed to result in increased invertebrate herbivory. However, empirical data about how current levels of invertebrate herbivory vary across the Arctic is limited and generally restricted to a single host plant or a small group of species, so predicting future change remains ...

Plants produce a wide array of secretions both above and below ground. Known as mucilages or exudates, they are secreted by seeds, roots, leaves and stems and fulfil a variety of functions including adhesion, protection, nutrient acquisition and infection. Mucilages are generally polysaccharide‐rich and often occur in the form of viscoelastic gels and in many cases have adhesive properties. In some ...

Climate change is modifying temperature and precipitation regimes across all seasons in northern ecosystems. Summer temperatures are higher, growing seasons extend into spring and fall and snow cover conditions are more variable during winter. The resistance of dominant tundra species to these season-specific changes, with each season potentially having contrasting effects on their growth and survival, ...

<OL> <LI>Spatial synchrony in population dynamics can be caused by dispersal or spatially correlated variation in environmental factors like weather (Moran effect). Distinguishing between these mechanisms is challenging for natural populations, and the study of dispersal‐induced synchrony in particular has been dominated by theoretical modelling and laboratory experiments. <LI>The goal of the ...

Polar cod (Boreogadus saida) are particularly vulnerable to climate change. Increasing our knowledge of polar cod development will help improve our understanding of the impact of climate change and the impacts this might have on the population. This study aimed at characterizing the development of Polar cod from fertilisation to 86 days post fertilisation (dpf) at two temperatures within their ...

Research over the last few decades has extended our understanding of nicotinamide adenine dinucleotide (NAD) from a vital redox carrier to an important signalling molecule that is involved in the regulation of a multitude of fundamental cellular processes. This includes DNA repair, cell cycle regulation, gene expression and calcium signalling, in which NAD is a substrate for several families of ...