Blar i forfatter Artikler, rapporter og annet (arktisk og marin biologi) "Sahm, Felix"

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    • Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma 

      Sharma, Suraj; Heiland, Ines; Panitz, Verena; Koncarevic, Sasa; Sadik, Ahmed; Friedel, Dennis; Bausbacher, Tobias; Trump, Saskia; Farztdinov, Vadim; Schulz, Sandra; Sievers, Philipp; Schmidt, Stefan; Jürgenson, Ina; Jung, Stephan; Kuhn, Karsten; Pflüger, Irada; Wick, Antje; Pfänder, Pauline; Selzer, Stefan; Vollmuth, Philipp; Sahm, Felix; von deimling, Andreas; Hopf, Carsten; Schulz-Knappe, Peter; Pike, Ian; Platten, Michael; Wick, Wolfgang; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-03)
      Tryptophan (Trp)-catabolic enzymes (TCEs) produce metabolites that activate the aryl hydrocarbon receptor (AHR) and promote tumor progression and immunosuppression in glioblastoma. As therapies targeting TCEs or AHR become available, a better understanding of Trp metabolism is required.<p> <P>Methods: The combination of LC-MS/MS with chemical isobaric labeling enabled the simultaneous quantitative ...