Studies of JAK/STAT signaling in Atlantic salmon

Sobhkhez, Mehrdad

dc.contributor.advisor	Jørgensen, Jorunn B.
dc.contributor.author	Sobhkhez, Mehrdad
dc.date.accessioned	2014-06-30T08:49:35Z
dc.date.available	2014-06-30T08:49:35Z
dc.date.issued	2014-06-27
dc.description.abstract	In mammals the JAK-STAT pathway plays a significant role in mediating the biological activities of both type I and type II IFN, where JAKs are receptor associated kinases and STATs the transcription factors they activate. At the start of this project the knowledge of the JAK-STAT pathway in fish in general was scarce and there were few reports describing the function of any JAK-STAT family member in the Atlantic salmon. There was also very limited knowledge about molecules involved in regulation of this signaling pathway in fish. In this project period we have cloned and / or initiated studies of the functional activity of the transcription factors STAT1, STAT2 and IRF9 and also the TYK2 kinase, as well as several members of the suppressors of cytokine signaling (SOCS) family derived from salmon.	en
dc.description.doctoraltype	ph.d.	en
dc.description.popularabstract	Dette arbeidet ble utført for å utdype forståelsen av JAK/STAT signalering hos laks. I perioden 2010 til 2014 ble flere viktige proteiner involvert i JAK/STAT signaleringen hos laks klonet vi og karakterisert. Molekylene som ble klonet og karakterisert er STAT2a, STAT2b, IRF9, også flere SOCS proteiner, vi også videre karakteriserte STAT1a. Kloning av disse molekylene gir oss viktige verktøy i videre studie av laksens immun respons til virus infeksjon og virusets immun unnvikelse strategier.	en
dc.description.sponsorship	This study was supported by Aquaculture program of The Research Council of Norway (grant no 185217/40)	en
dc.description	The papers of this thesis are not available in Munin: <br/>1. Mehrdad Sobhkhez, Tom Hansen, Dimitar B. Iliev, Astrid Skjesol, Jorunn B. Jørgensen: 'The Atlantic salmon protein tyrosine kinase Tyk2: molecular cloning, modulation of expression and function', Developmental & Comparative Immunology (2013), vol. 41(4):553–563. Available at <a href=http://dx.doi.org/10.1016/j.dci.2013.07.008>http://dx.doi.org/10.1016/j.dci.2013.07.008</a> <br/>2. Sobhkhez, M., Skjesol, A., Thomassen E., Greiner–Tollersrud L., Iliev, D.B., Sun, B., Robertsen B. & J. B. Jørgensen: 'Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on IFN signaling in teleosts' (manuscript). <br/>3. Astrid Skjesol, Theresa Liebe, Dimitar B. Iliev, Ernst I Thomassen, Linn G. Tollersrud, Mehrdad Sobhkhez, Lisbeth Lindenskov Joensen, Chris J. Secombes and Jorunn B. Jørgensen: 'Functional conservation of suppressors of cytokine signaling proteins between teleosts and mammals: Atlantic salmon SOCS1 binds to JAK/STAT family members and suppresses type I and II IFN signaling', Developmental & Comparative Immunology (2014), 45(1):177–189. Available at <a href=http://dx.doi.org/10.1016/j.dci.2014.02.009>http://dx.doi.org/10.1016/j.dci.2014.02.009</a>	en
dc.identifier.isbn	978-82-8266-083-9
dc.identifier.uri	https://hdl.handle.net/10037/6440
dc.identifier.urn	URN:NBN:no-uit_munin_6011
dc.language.iso	eng	en
dc.publisher	UiT The Arctic University of Norway	en
dc.publisher	UiT Norges arktiske universitet	en
dc.rights.accessRights	openAccess
dc.rights.holder	Copyright 2014 The Author(s)
dc.rights.uri	https://creativecommons.org/licenses/by-nc-sa/3.0	en_US
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)	en_US
dc.subject	VDP::Teknologi: 500::Bioteknologi: 590	en
dc.subject	VDP::Technology: 500::Biotechnology: 590	en
dc.title	Studies of JAK/STAT signaling in Atlantic salmon	en
dc.type	Doctoral thesis	en
dc.type	Doktorgradsavhandling	en

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