• Evolutionary consequences of genomic deletions and insertions in the woolly mammoth genome 

      van der Valk, Tom; Dehasque, Marianne; Chacón-Duque, J. Camilo; Oskolkov, Nikolay; Vartanyan, Sergey; Heintzman, Peter D.; Pečnerová, Patrícia; Díez-del-Molino, David; Dalén, Love (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-01)
      Woolly mammoths had a set of adaptations that enabled them to thrive in the Arctic environment. Many mammoth-specific single nucleotide polymorphisms (SNPs) responsible for unique mammoth traits have been previously identified from ancient genomes. However, a multitude of other genetic variants likely contributed to woolly mammoth evolution. In this study, we sequenced two woolly mammoth genomes and ...
    • Million-year-old DNA sheds light on the genomic history of mammoths 

      van der Valk, Tom; Pečnerová, Patrícia; Díez-del-Molino, David; Bergström, Anders; Oppenheimer, Jonas; Hartmann, Stefanie; Xenikoudakis, Georgios; Thomas, Jessica A.; Dehasque, Marianne; Sağlıcan, Ekin; Rabia Fidan, Fatma; Barnes, Ian; Liu, Shanlin; Somel, Mehmet; Heintzman, Peter D.; Nikolskiy, Pavel; Shapiro, Beth; Skoglund, Pontus; Hofreiter, Michael; Lister, Adrian M.; Götherström, Anders; Dalén, Love (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-17)
      Temporal genomic data hold great potential for studying evolutionary processes such as speciation. However, sampling across speciation events would, in many cases, require genomic time series that stretch well back into the Early Pleistocene subepoch. Although theoretical models suggest that DNA should survive on this timescale1, the oldest genomic data recovered so far are from a horse specimen ...