Although chronic myeloid leukemia (CML) can be effectively treated using BCR‑ABL1 kinase inhibitors, resistance due to kinase alterations or to BCR‑ABL1 independent mechanisms remain a therapeutic challenge. For the latter, the underlying mechanisms are widely discussed; for instance, gene expression changes, epigenetic factors and alternative signaling pathway activation. In the present study, in ...

Global warming has shifted phenological traits in many species, but whether species are able to track further increasing temperatures depends on the fitness consequences of additional shifts in phenological traits. To test this, we measured phenology and fitness of great tits (Parus major) with genotypes for extremely early and late egg lay dates, obtained from a genomic selection experiment. ...

The species of <i>Massalongia</i> recorded and described from the Southern Hemisphere are revised and it is shown that only one is present; <i>M. patagonica</i> which is widespread, with populations in Australia and New Zealand that differ from the South American populations, but at present best regarded as part of the variation of that species. Records from this hemisphere of all other species ...

Background: Equitable mental healthcare regardless of area of residence is a political aim in Norway. The purpose of this study is to evaluate geographical variation in private practitioner coverage and explore differences between private practitioners with public reimbursement and local community mental health centers (CMHCs) in terms of diagnoses and scope of outpatient treatment, with a focus on ...

Rates of ADHD diagnosis vary across regions in many countries. However, no prior study has investigated how much within-country geographic variation in ADHD diagnoses is explained by variation in ADHD symptom levels. We examine whether ADHD symptom levels explain variation in ADHD diagnoses among children and adolescents using nationwide survey and register data in Norway. Geographical variation in ...

This report considers measurements of geomagnetically induced current (GIC) and comparison to recorded variations in the geomagnetic field (dB/dt). The GIC-sensors were installed in the neutral point of a 420 kV transformer located in Mid-Norway in 2019. The magnetometers (for dB/dt) are also located in Mid-Norway, but at another location. Recordings up to December 2021 are presented in this report. ...

BACKGROUND: There is a need for the development of accurate, accessible and efficient screening instruments, focused on early-stage detection of neurocognitive disorders. The Geras Solutions cognitive test (GSCT) has showed potential as a digital screening tool for cognitive impairment but normative data are needed.<p> <p>OBJECTIVE: The aim of this study was to obtain normative data for the ...

We demonstrate how to get Hamaker coefficients with an amplitude-modulation AFM operated in standard tapping mode. The Hamaker coefficient is a physical parameter that provides chemical information about the surface of samples. It is based or emerges from van der Waals forces. We use a Cypher scanning probe microscope from Asylum Research to demonstrate the method. The method is based on the research ...

More than 40 Australasian collections of the genus <i>Gibbosporina</i> have been studied and found to confirm the concepts of the six species previously known from Australia and Papua New Guinea. Perispore morphology is the character most useful for identification. <i>Gibbosporina nitida</i> appears to be the most common species in the area. <i>Gibbosporina elixii</i> and <i>G. leptospora</i> ...

Computational methods are increasingly used to support interpreting, assigning and predicting the solid-state nuclear resonance magnetic spectra of materials. Currently, density functional theory is seen to achieve a good balance between efficiency and accuracy in solid-state chemistry. To be specific, density functional theory allows the assignment of signals in nuclear resonance magnetic spectra ...