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  • EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer 

    Boye, Kjetil; Nesland, Jahn M; Sandstad, Berit; Haugen, Mads Haugland; Mælandsmo, Gunhild; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-07-10)
    BACKGROUND: Proteolytic enzymes and their regulators have important biological roles in colorectal cancer by stimulating invasion and metastasis, which makes these factors attractive as potential prognostic biomarkers. METHODS: The expression of extracellular matrix metalloproteinase inducer (EMMPRIN) was characterised using immunohistochemistry in primary tumours from a cohort of 277 prospectively ...
  • Accuracy of Molecular Simulation-Based Predictions of koff Values: A Metadynamics Study 

    Capelli, Riccardo; Lyu, Wenping; Bolnykh, Viacheslav; Meloni, Simone; Olsen, Jógvan Magnus Haugaard; Rothlisberger, Ursula; Parrinello, Michele; Carloni, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-16)
    The koff values of ligands unbinding to proteins are key parameters for drug discovery. Their predictions based on molecular simulation may under- or overestimate experiment in a system- and/or technique-dependent way. Here we use an established method infrequent metadynamics, based on the AMBER force field to compute the koff of the ligand iperoxo (in clinical use) targeting the muscarinic receptor ...
  • Seasonal pollutant levels in littoral high-Arctic amphipods in relation to food sources and terrestrial run-off 

    Skogsberg, Stina Linnea Emelie; Mcgovern, Maeve; Poste, Amanda; Jonsson, Sofi; Arts, Michael T.; Varpe, Øystein; Borgå, Katrine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-03)
    Increasing terrestrial run-off from melting glaciers and thawing permafrost to Arctic coastal areas is expected to facilitate re-mobilization of stored legacy persistent organic pollutants (POPs) and mercury (Hg), potentially increasing exposure to these contaminants for coastal benthic organisms. We quantified chlorinated POPs and Hg concentrations, lipid content and multiple dietary markers, in a ...
  • A qualitative study of final-year medical students’ perspectives of general practitioners’ competencies 

    Landstrøm, Bjørn; Mattsson, Bengt; Rudebeck, Carl Edvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-09-23)
    Objectives: To investigate final-year medical students' perspectives of general practitioners' competencies. A further aim of the study was to investigate which type of clinical problems is properly managed by GPs according to students.<p> <p>Methods: We conducted a qualitative study of 49 final year medical students from two programmes. Reflective writing statements were used to collect data. ...
  • Comparison of effectiveness and safety between granules and decoction of Chinese herbal medicine: A systematic review of randomized clinical trials 

    Luo, Hui; Li, Qing; Flower, Andrew; Lewith, George; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-02-09)
    Background: The clinical use of Chinese herbal medicine granules is gradually increasing. However, there is still no systematic review comparing the effectiveness and safety of granules with the more traditional method of herbal decoctions.<p> <p>Method: A literature search was conducted using China National Knowledge Infrastructure Databases (CNKI), Chinese Science and Technology Periodical ...
  • Pastoral herding strategies and governmental management objectives: predation compensation as a risk buffering strategy in the Saami reindeer husbandry 

    Næss, Marius Warg; Bårdsen, Bård-Jørgen; Pedersen, Elisabeth; Tveraa, Torkild (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-05-12)
    Previously it has been found that an important risk buffering strategy in the Saami reindeer husbandry in Norway is the accumulation of large herds of reindeer as this increases long-term household viability. Nevertheless, few studies have investigated how official policies, such as economic compensation for livestock losses, can influence pastoral strategies. This study investigated the effect of ...
  • Bone-Specific Drugs and Osteonecrosis of Sites Other Than the Jaw: A Nationwide Cohort Study 

    Nordstrom, Peter; Bergman, Jonathan; Ballin, Marcel; Bjork, Sabine; Nordström, Anna Hava (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-07)
    Bone-specific drugs (BSDs) increase the risk of osteonecrosis of the jaw (ONJ), but whether they increase the risk of osteonecrosis at other sites is not known. Two studies, a cohort study and a case–control study, were conducted using registry data on everyone who was residing in Sweden on December 31, 2005, and who was 50 years of age or older at the time (n = 3,523,912). In the cohort study, ...
  • Oxidative addition of methyl iodide to [Rh(PhCOCHCOPh)(CO)(P(OCH2)(3)CCH3)]: an experimental and computational study 

    Erasmus, Johannes J. C.; Conradie, Jeanet (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-11-24)
    The reaction rate of the oxidative addition and CO insertion steps of methyl iodide with [Rh(PhCOCHCOPh)(CO)(P(OCH<sub>2</sub> ) <sub>3</sub> CCH<sub>3</sub> )] are presented. Large negative experimental values for the activation entropy and results from a density functional theory computational chemistry study indicated trans addition of the CH<sub>3</sub> I to [Rh(PhCOCHCOPh)(CO)(P(OCH<su ...
  • Mapping the Concept, Content, and Outcome of Family-Based Outdoor Therapy for Children and Adolescents with Mental Health Problems: A Scoping Review 

    Stea, Tonje Holte; Jong, MC; Fegran, Liv; Sejersted, Ellen; Jong, M.; Wahlgren, SLF; Fernee, Carina Ribe (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-10)
    Outdoor therapy and family-based therapy are suggested to be promising interventions for the treatment of mental health problems. The aim of the present scoping review was to systematically map the concept, content, and outcome of combining family- and outdoor-based therapy for children and adolescents with mental health problems. The Joanna Briggs Institute methodology and PRISMA guidelines ...
  • Alcohol consumption and lower risk of cardiovascular and all-cause mortality: the impact of accounting for familial factors in twins 

    Ystrøm, Eivind; Degerud, Eirik Magnus Meek; Tesli, Martin Steen; Høye, Anne; Reichborn-Kjennerud, Ted; Næss, Øyvind Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-20)
    Background. A moderate to high alcohol consumption is associated with a lower risk of cardiovascular disease (CVD) mortality in comparison with low consumption. The mechanisms underlying this association are not clear and have been suggested to be caused by residual confounding. The main objective of this study was to separate the familial and individual risk for CVD mortality and all-cause mortality ...
  • What should have happened if Hardy had discovered this? 

    Persson, Lars Erik; Samko, N (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-02-15)
    First we present and discuss an important proof of Hardy’s inequality via Jensen’s inequality which Hardy and his collaborators did not discover during the 10 years of research until Hardy finally proved his famous inequality in 1925. If Hardy had discovered this proof, it obviously would have changed this prehistory, and in this article the authors argue that this discovery would probably also ...
  • U-Pb dating of calcite in ancient carbonates for age estimates of syn-to post-depositional processes: A case study from the upper Ediacaran strata of Finnmark, Arctic Norway 

    Meinhold, Guido; Roberts, Nick M.W.; Arslan, Arzu; Jensen, Sören; Ebbestad, Jan Ove R.; Högström, Anette; Høyberget, Magne; Agić, Heda; Palacios, Teodoro; Taylor, Wendy L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-10)
    Results of in situ U–Pb dating of calcite spherulites, cone-in-cone (CIC) calcite and calcite fibres from a calcareous concretion of the upper Ediacaran of Finnmark, Arctic Norway, are reported. Calcite spherulites from the innermost layers of the concretion yielded a lower intercept age of 563 ± 70 Ma, which, although imprecise, is within uncertainty of the age of sedimentation based on fossil ...
  • Night-shift work and hematological cancers: A population based case-control study in three Nordic countries 

    Talibov, Madar; Pukkala, Eero; Martinsen, Jan Ivar; Tryggvadottir, Laufey; Weiderpass, Elisabete; Hansen, Johnni (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-11)
    <b><p>Objective</b> The aim of this case–control study was to assess the effect of night-shift work on the risk of hematological cancers. <b><p>Methods</b> The study included 39 371 leukemia, 56 713 non-Hodgkin lymphoma, 9322 Hodgkin lymphoma, and 26 188 multiple myeloma cases diagnosed between 1961 and 2005 in Finland, Sweden, and Iceland. Five controls for each case were selected from the Nordic ...
  • Safety and efficacy of epithelium-on corneal collagen cross-linking using a multifactorial approach to achieve proper stromal riboflavin saturation 

    Stojanovic, Aleksandar; Chen, Xiangjun; Jin, Nan; Zhang, Ting; Stojanovic, Filip; Ræder, Sten; Utheim, Tor Paaske (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-07-30)
    Purpose. To evaluate the efficacy and safety of epithelium-on corneal collagen cross-linking (CXL) using a multifactorial approach to achieve proper stromal riboflavin saturation. Methods. This non-randomized retrospective study comprised 61 eyes with progressive keratoconus treated with epithelium-on CXL. Chemical epithelial penetration enhancement (benzalkonium chloride-containing local medication ...
  • Improving the relationships between Indigenous rights holders and researchers in the Arctic: an invitation for change in funding and collaboration 

    Doering, Nina; Dudeck, Stephan; Elverum, Shelly; Fisher, Charleen; Henriksen, Jan-Erik; Herrmann, Thora Martina; Milton, Justin; Kramvig, Britt; Laptander, Roza; Omma, Elle Merete; Saxinger, Gertrude; Scheepstra, Annette J M; Wilson, Katherine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-10)
    Truly transdisciplinary approaches are needed to tackle the complex problems that the Arctic is facing at the moment. Collaboration between Indigenous rights holders and researchers through co-creative research approaches can result in high-quality research outcomes, but crucially also address colonial legacies and power imbalances, enhance mutual trust, and respect the rights of Indigenous ...
  • Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational study 

    Magnúsdóttir, Ingibjörg; Lovik, Anikó; Unnarsdóttir, Anna Bára; McCartney, Daniel L.; Ask, Helga; Kõiv, Kadri; Christoffersen, Lea Arregui Nordahl; Johnson, Sverre Urnes; Hauksdóttir, Arna; Fawns-Ritchie, Chloe; Helenius, Dorte; Lu, Li; Ebrahimi, Omid Vakili; Hoffart, Asle; Porteous, David J; Fang, Fang; Jakobsdottir, Johanna; Lehto, Kelli; Andreassen, Ole; Pedersen, Ole; Aspelund, Thor; Valdimarsdottir, Unnur Anna (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-14)
    <p><b>Background</b> Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public health concern. Little is still known about the long-term mental health of non-hospitalised patients with COVID-19 with varying illness severities. Our aim was to assess the prevalence of adverse mental health symptoms among individuals diagnosed with COVID-19 in the general ...
  • ‘Call the Norwegian embassy!’: The Alta conflict, Indigenous narrative and political change in the activist films The Taking of Sámiland and Let the River Live 

    Sand, Stine Agnete (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-01)
    In the 1970s, Norway had not officially acknowledged their Indigenous population, the Sámi. In the following decade, two activist films, Let the River Live (Greve 1980) and The Taking of Sámiland (Eriksen and Tannvik 1984), focused on the Alta conflict ‐ protests against the construction of a power plant in Sámi territory ‐ Indigenous rights and colonial processes. Inspired by discussions concerning ...
  • The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016 

    Holmquist, Sofie; Nordström, Anna Hava; Nordström, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)
    <p><b>Background</b> Depression is associated with an increased risk of dementia. However, short follow-up times and lack of adjustment for familial factors in previous studies could influence this association. The purpose of the present study was to investigate the association between depression and subsequent dementia, while controlling for familial factors and with a follow-up of over 35 ...
  • Strengere kontroll av kunnskapsoverføring gir dreining av internasjonalt forskningssamarbeid 

    Olsen, Dag Rune; Brekke, Camilla (Chronicle; Kronikk, 2022-04-22)
    I disse dager jobber vi med høringssvar til de reviderte retningslinjene for kontroll av kunnskapsoverføring, det såkalte eksportkontrollregelverket. Som et mørkt bakteppe, ligger krigen i Ukraina og myndighetenes årlige trusselvurdering.
  • Hjerte- og skjelettmuskelbetennelse (HSMB) hos lakseyngel i settefiskanlegg 

    Furnesvik, Lisa; Erkinharju, Toni (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
    I oktober 2019 mottok Veterinærinstituttet en innsendelse med 13 grams lakseyngel fra et settefiskanlegg i Nord-Norge. Det ble rapportert om vedvarende økt dødelighet etter dyppvaksinering. Andre kliniske funn var gjellelokkforkortelse av varierende grad. Det var observert få svimere, og fisken hadde god appetitt.

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