Chalabianloo, Fatemeh; Fadnes, Lars T.; Johansson, Kjell Arne; Høiseth, Gudrun; Vold, Jørn Henrik; Kringen, Marianne K.; Spigset, Olav; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-20)
Background: A considerable inter-individual variability has been reported in
the relationship between methadone doses applied and serum concentrations
achieved in methadone maintenance treatment. However, the underlying
causes for this variability are not fully understood.<p>
<p>Objectives: We investigated the influence of genetic, pathophysiological and
pharmacological factors on serum methadone ...