Blar i forfatter Universitetsbiblioteket "Ottestad, William Arne"

Viser treff 1-2 av 2

    • Biphasic release of the alarmin high mobility group box 1 protein early after trauma predicts poor clinical outcome 

      Ottestad, William Arne; Rognes, Ingrid Nygren; Pischke, Søren; Mollnes, Tom Eirik; Andersson, Ulf; Eken, Torsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08)
      <i>Objective</i>: The causal role of the prototype alarmin high mobility group box 1 protein (HMGB1) in systemic inflammation and remote organ injury after trauma and shock is established in animal models but not in humans. Our aim was therefore to determine HMGB1 concentration kinetics with high time resolution during the first hours after trauma in individual patients, and investigate the ...

    • Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study 

      Sundnes, Olav; Ottestad, William Arne; Schjalm, Camilla; Lundbäck, Peter; La Cour Poulsen, Lars; Mollnes, Tom Eirik; Haraldsen, Guttorm; Eken, Torsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-26)
      Background - Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In this study we explored high-resolution concentration kinetics of the alarmin interleukin-33 (IL-33) early after human trauma.<p> <p>Methods - ...