ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraakEnglish 
    • EnglishEnglish
    • norsknorsk
  • Administration/UB
View Item 
  •   Home
  • Fakultet for naturvitenskap og teknologi
  • Institutt for matematikk og statistikk
  • Artikler, rapporter og annet (matematikk og statistikk)
  • View Item
  •   Home
  • Fakultet for naturvitenskap og teknologi
  • Institutt for matematikk og statistikk
  • Artikler, rapporter og annet (matematikk og statistikk)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

COPD in primary lung cancer patients: prevalence and mortality

Permanent link
https://hdl.handle.net/10037/9082
DOI
dx.doi.org/10.2147/COPD.S101183
Thumbnail
View/Open
article.pdf (1.123Mb)
(PDF)
Date
2016-03-23
Type
Journal article
Peer reviewed
Tidsskriftartikkel

Author
Ytterstad, Elinor; Moe, Per Christian; Hjalmarsen, Audhild
Abstract
Background: Previous studies have relied on international spirometry criteria to diagnose COPD in patients with lung cancer without considering the effect lung cancer might have on spirometric results. The aim of this study was to examine the prevalence of COPD and emphysema at the time of primary lung cancer diagnosis and to examine factors associated with survival. Materials and methods: Medical records, pulmonary function tests, and computed tomography scans were used to determine the presence of COPD and emphysema in patients diagnosed with primary lung cancer at the University Hospital of North Norway in 2008–2010. Results: Among the 174 lung cancer patients, 69% had COPD or emphysema (39% with COPD, 59% with emphysema; male:female ratio 101:73). Neither COPD nor emphysema were significantly associated with lung cancer mortality, whereas patients with non-small-cell lung cancer other than adenocarcinoma and squamous cell carcinoma had a risk of lung cancer mortality that was more than four times higher than that of patients with small-cell lung cancer (hazard ratio [HR] 4.19, 95% confidence interval [CI] 1.56–11.25). Females had a lower risk of lung cancer mortality than males (HR 0.63, 95% CI 0.42–0.94), and patients aged ≥75 years had a risk that was twice that of patients aged <75 years (HR 2.48, 95% CI 1.59–3.87). Low partial arterial oxygen pressure (4.0–8.4 kPa) increased the risk of lung cancer mortality (HR 2.26, 95% CI 1.29–3.96). So did low partial arterial carbon dioxide pressure (3.0–4.9 kPa) among stage IV lung cancer patients (HR 2.23, 95% CI 1.29–3.85). Several patients with respiratory failure had previously been diagnosed with COPD. Conclusion: The observed prevalence of COPD was lower than that in previous studies. Neither COPD nor emphysema were significantly associated with lung cancer mortality.
Description
Published version, also available at http://dx.doi.org/10.2147/COPD.S101183. Creative Commons Attribution - Non Commercial (unported, v3.0) License
Publisher
Dove medical Press
Citation
The International Journal of Chronic Obstructive Pulmonary Disease 2016, 11(1):625-636
Metadata
Show full item record
Collections
  • Artikler, rapporter og annet (matematikk og statistikk) [357]

Browse

Browse all of MuninCommunities & CollectionsAuthor listTitlesBy Issue DateBrowse this CollectionAuthor listTitlesBy Issue Date
Login

Statistics

View Usage Statistics
UiT

Munin is powered by DSpace

UiT The Arctic University of Norway
The University Library
uit.no/ub - munin@ub.uit.no

Accessibility statement (Norwegian only)