Blar i forfatter "Hansen, John-Bjarne"

Viser treff 21-40 av 96

    • D-Dimer Measured At First Venous Thromboembolism Is Associated With Future Risk Of Cancer 

      Gran, Olga Vikhammer; Brækkan, Sigrid Kufaas; Paulsen, Benedikte; Skille, Hanne; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12)
      D-dimer >5000 ng/ml at incident VTE is associated with a higher risk of subsequent cancer within one and two years. High D-dimer levels are also associated with more aggressive tumor biology and poor prognosis in these patients. As D-dimer is routinely measured in the assessment of suspected VTE, it may be a useful surrogate marker for the presence of an underlying malignancy. Our findings may suggest ...

    • Dietary intake of marine n-3 polyunsaturated fatty acids and future risk of venous thromboembolism 

      Isaksen, Trond; Evensen, Line Holtet; Johnsen, Stein Harald; Jacobsen, Bjarne K.; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      <p><i>Background</i>: Studies on the association between long‐chained n‐3 polyunsaturated fatty acids (n‐3 PUFAs) and risk of venous thromboembolism (VTE) are conflicting, potentially due to challenges related to assessment of n‐3 PUFA intake and changes in diet during follow‐up.</p> <p><i>Objectives</i>: To investigate whether dietary intake of marine n‐3 PUFAs was associated with risk of incident ...

    • Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism 

      Isaksen, Trond; Evensen, Line Holtet; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-28)
      <i>Background</i> - Limited knowledge exists on the association between intake of long-chained n-3 polyunsaturated fatty acids (n-3 PUFAs) and risk of recurrence and all-cause mortality in patients with venous thromboembolism (VTE).<p><p> <i>Objectives</i> - This article investigates whether intake of marine n-3 PUFAs was associated with risk of recurrence and mortality in patients with incident ...

    • Effect of Unfractionated Heparin on TFPI Elimination 

      Øie, Cristina Ionica; Appa, Rupa Shree; Brodin, Ellen; Hilden, Ida; Smedsrød, Bård; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel, 2010)
      Background: Tissue factor pathway inhibitor (TFPI) plays an important role for the anticoagulant effect of heparin. Depletion of intravascular TFPI by treatment with unfractionated heparin (UFH), and not by low molecular weight heparin (LMWH), has been suggested to explain the superiority of LMWH in treatment of both arterial and venous thrombosis. The present study was undertaken to investigate ...

    • Effective filtering strategies to improve data quality from population-based whole exome sequencing studies 

      Carson, Andrew; Smith, Erin N; Matsui, Hiroko; Brækkan, Sigrid Kufaas; Jepsen, Kristen; Hansen, John-Bjarne; Frazer, Kelly (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism 

      Skjeflo, Espen Waage; Brækkan, Sigrid Kufaas; Ludviksen, Judith K; Snir, Omri; Hindberg, Kristian; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      The role of complement in the pathogenesis of venous thromboembolism (VTE) is unclear. We wanted to investigate (1) whether plasma complement component C5 (C5) levels are influenced by genetic variants or chronic inflammation and (2) the association between plasma C5 and risk of future VTE in a nested case-control study of 415 patients with VTE and 848 age- and sex-matched controls derived from the ...

    • Elevated Plasma Levels of P‐Selectin Glycoprotein Ligand‐1 Positive Microvesicles in Patients with Unprovoked Venous Thromboembolism 

      Jamaly, Simin; Basavaraj, Manjunath Goolyam; Starikova, Irina; Olsen, Randi; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-31)
      Background<br> Microvesicles (MVs) express antigens from their parental cells and have a highly procoagulant surface. Animal studies suggest that P‐Selectin Glycoprotein Ligand‐1 positive (PSGL‐1+) MVs play a role in the pathogenesis of venous thromboembolism (VTE).<p> Objective<br> The aim of this study was to determine plasma levels, the cellular origin and the morphological characteristics ...

    • Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death 

      Arnesen, Carl Arne Løchen; Veres, Katalin; Horváth-Puhó, Erzsébet; Hansen, John-Bjarne; Sørensen, Henrik Toft; Brækkan, Sigrid K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-08)
      Incidence of venous thromboembolism (VTE) risk varies by age and sex. Some studies have reported overall higher risk in men, especially when VTEs triggered by female reproductive factors are excluded. However, higher mortality rates in men may have led to overestimation of lifetime VTE risk in men compared with women. Therefore, we estimated the lifetime risk of VTE in men and women in a Danish, ...

    • Evaluation of the medical student research programme in Norwegian medical schools : a survey of students and supervisors 

      Hansen, John-Bjarne; Hunskaar, Steinar; Breivik, Jarle; Figenschau, Kristian; Siebke, Maje; Tømmerås, Karin (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-07-14)
      Background: The Medical Student Research Programme is a national education and grant scheme for medical students who wish to carry out research in parallel with their studies. The purpose of the programme is to increase recruitment of people with a standard medical degree to medical research. The Research Programme was established in 2002 and underwent a thorough evaluation during the spring of ...

    • Evaluation of the medical student research programme in Norwegian medical schools. A survey of students and supervisors 

      Hunskaar, Steinar; Figenschau, Kristian; Hansen, John-Bjarne; Breivik, Jarle; Siebke, Else-Marie; Tømmerås, Karin (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

    • Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort 

      Jensvoll, Hilde; Severinsen, Marianne T.; Hammerstrøm, Jens; Brækkan, Sigrid Kufaas; Kristensen, Søren R.; Cannegieter, Suzanne C.; Blix, Kristine; Tjønneland, Anne; Rosendaal, Frits Richard; Dziewiecka, Olga; Overvad, Kim; Næss, Inger Anne; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-16)
      Background: Although venous thromboembolism (VTE) is a known common complication in cancer patients, there is limited knowledge on patient-related and cancer-specific risk factors in the general population. The Scandinavian Thrombosis and Cancer (STAC) Cohort was established by merging individual data from three large Scandinavian cohorts (The Tromsø Study, the second Nord-Trøndelag Health Study, ...

    • Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism - The Tromsø Study 

      Lind, Caroline; Enga, Kristin Fjeldstad; Mathiesen, Ellisiv B.; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism 

      Paulsen, Benedikte; Skille, Hanne; Smith, Erin N.; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brækkan, Sigrid Kufaas; Rosendaal, Frits Richard; Frazer, Kelly A.; Gran, Olga Vikhammer; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
      Venous thromboembolism is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of venous thromboembolism, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of venous thromboembolism. Cases with incident venous ...

    • Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study 

      Johnsen, Stein Harald; Jacobsen, Bjarne K.; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-25)
      Background: <br>Whether long-chain n–3 PUFAs of marine origin have an anti-atherogenic effect in the general population has hardly been studied. In this population-based study, we hypothesized that fatty fish and fish oil intake protect against development of novel atherosclerotic plaques and is associated with reduced plaque size.<br> Methods: <br>We obtained questionnaire-based information ...

    • Genetic Variation Of Platelet Glycoprotein VI And The Risk Of Venous Thromboembolism 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)
      Family studies have indicated that heritability explains 50-60% of the venous thromboembolism (VTE) events, and in recent years, several single nucleotide polymorphisms (SNPs) have been found to influence the VTE risk. Glycoprotein 6 (GP6) rs1613662, also known as T13254C, is an A/G single nucleotide variation in amino acid 219, which results in a serine to proline substitution affecting ...

    • Hematocrit and risk of venous thromboembolism in a general population. The Tromso study 

      Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Hemostatic factors, inflammatory markers, and risk of incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis 

      Evensen, Line Holtet; Folsom, Aaron R.; Pankow, James S.; Hansen, John-Bjarne; Allison, Matthew; Cushman, Mary; Lutsey, Pamela L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-27)
      Background - Several hemostatic factors and inflammatory markers are associated with the risk of incident venous thromboembolism (VTE), however, most existing data are from case-control studies in Caucasian populations.<p> <p>Objectives - We aimed to prospectively confirm previous findings and explore less studied biomarkers in relation to VTE risk in a multi-racial/multi-ethnic cohort.<p> <p>Methods ...

    • High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study 

      Hald, Erin Mathiesen; Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population. ...

    • Hospitalization as a trigger for venous thromboembolism – Results from a population-based case-crossover study 

      Bjøri, Esben; Johnsen, Håkon Sandbukt; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-21)
      <i>Background</i> - Previous studies have reported that around 50% of patients with venous thromboembolism (VTE) has undergone recent hospitalization. However, studies on the impact of hospitalization as a trigger factor for VTE are limited.<p><p> <i>Objectives</i> - To investigate the impact of hospitalization with and without concurrent immobilization as a trigger factor for VTE.<p><p> ...

    • Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study 

      Lerstad, Gunhild; Brodin, Ellen Elisabeth; Enga, Kristin; Jorde, Rolf; Schirmer, Henrik; Njølstad, Inger; Svartberg, Johan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)
      Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) ...