Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study
Permanent lenke
https://hdl.handle.net/10037/8229Dato
2014-03-05Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Lerstad, Gunhild; Brodin, Ellen Elisabeth; Enga, Kristin; Jorde, Rolf; Schirmer, Henrik; Njølstad, Inger; Svartberg, Johan; Brækkan, Sigrid Kufaas; Hansen, John-BjarneSammendrag
Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose
during the last 8-12 weeks, is associated with future risk of cardiovascular disease
(CVD) and all-cause mortality.
Objectives: To examine the association between hyperglycemia, assessed by
HbA1c, and future risk of VTE in a population based cohort.
Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) who
participated in one or more surveys of the Tromsø study (Tromsø 4; 1994-95,
Tromsø 5; 2001-2, and Tromsø 6; 2007-8). All subjects were followed, and incident
VTE events were recorded through December 31, 2010.
Results: There were 333 validated first VTE events, of which 137 were unprovoked,
during a median follow-up of 7.1 years. HbA1c was not associated with future risk of
VTE in analysis treating HbA1c as a continuous variable, or in categorized analyses.
The risk of VTE increased by 5% per 1 SD (0.7%) increase in HbA1c (multivariableadjusted
HR 1.05; 95% CI 0.97-1.14), and subjects with HbA1c ≥ 6.5% had 27%
higher risk compared to those with HbA1c below 5.7% (multivariable-adjusted HR
1.27; 95% CI 0.72-2.26). There was no significant linear trend for increased risk of
VTE across categories of HbA1c (p=0.27).
Conclusions: Serum levels of HbA1c were not associated with future risk of VTE in
multivariable analysis. Our findings suggest that hyperglycemia does not play an
important role in the pathogenesis of VTE
Beskrivelse
This is the accepted manuscript version. Published version, with slightly altered title, is available in Journal of Thrombosis and Haemostasis 12(2014)
Forlag
Blackwell PublishingSitering
Journal of Thrombosis and Haemostasis 12(2014) nr. 3 s. 313-319Metadata
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