• Blood pressure target achievement and antihypertensive medication use in women and men after first-ever myocardial infarction: the Tromsø Study 1994-2016 

      Hopstock, Laila Arnesdatter; Eggen, Anne Elise; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Nilsen, Amalie; Njølstad, Inger; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-03)
      Background: <br> Recurrent cardiovascular events after myocardial infarction (MI) are frequent, and gender differences in blood pressure treatment have been reported. Despite increased focus on secondary prevention, recent reports indicate that treatment targets are not achieved. There is a need for gender-specific analyses of post-MI blood pressure treatment target achievement and ...
    • Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study 

      Wilsgaard, Tom; Loehr, LR; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Bønaa, Kaare Harald; Njølstad, Inger; Heiss, G (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-06)
      Background: The American Heart Association has proposed an impact goal for the year 2020 to improve cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact fraction (GIF). <p>Methods: The health metric score was derived from ideal ...
    • CHA2DS2-VASc score, left atrial size and atrial fibrillation as stroke risk factors in the Tromsø Study 

      Tiwari, Sweta; Løchen, Maja-Lisa; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Njølstad, Inger; Mathiesen, Ellisiv B.; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-01)
      Objective:<br> CHA2DS2-VASc score, left atrial (LA) size and atrial fibrillation (AF) have individually been associated with stroke risk. Our aim was to investigate the predictive ability of combinations of these factors for the odds of incident stroke in a population-based cohort study.<br> Methods:<br> We followed 2844 participants from the Tromsø Study from 1994 to 2012. Information on LA size ...
    • Change in cardiovascular risk assessment tool and updated Norwegian guidelines for cardiovascular disease in primary prevention increase the population proportion at risk: The Tromsø Study 2015-2016 

      Nilsen, Amalie; Hanssen, Tove Aminda; Lappegård, Knut Tore; Eggen, Anne Elise; Løchen, Maja-Lisa; Selmer, Randi Marie; Njølstad, Inger; Wilsgaard, Tom; Hopstock, Laila Arnesdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-30)
      Aims - To compare the population proportion at high risk of cardiovascular disease (CVD) using the Norwegian NORRISK 1 that predicts 10-year risk of CVD mortality and the Norwegian national guidelines from 2009, with the updated NORRISK 2 that predicts 10-year risk of both fatal and non-fatal risk of CVD and the Norwegian national guidelines from 2017.<p> <p>Methods - We included participants ...
    • Clinical Synthetic Data Generation to Predict and Identify Risk Factors for Cardiovascular Diseases 

      García-Vicente, Clara; Chushig-Muzo, David; Mora-Jimenez, Inmaculada; Fabelo, Himar; Gram, Inger Torhild; Løchen, Maja-Lisa; Granja, Conceição; Soguero-Ruiz, Cristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-21)
      Noncommunicable diseases are among the most significant health threats in our society, being cardiovascular diseases (CVD) the most prevalent. Because of the severity and prevalence of these illnesses, early detection and prevention are critical for reducing the worldwide health and economic burden. Though machine learning (ML) methods usually outperform conventional approaches in many domains, class ...
    • Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation 

      Thorolfsdottir, Rosa B; Sveinbjornsson, Gardar; Sulem, Patrick; Nielsen, Jonas B.; Jonsson, Stefan; Halldorsson, Gisli H; Melsted, Pall; Ivarsdottir, Erna V; Davidsson, Olafur B; Kristjansson, Ragnar P; Thorleifsson, Gudmar; Helgadottir, Anna; Gretarsdottir, Solveig; Norddahl, Gudmundur; Rajamani, Sridharan; Torfason, Bjarni; Valgardsson, Atli S; Sverrisson, Jon T.; Tragante, Vinicius; Holmen, Oddgeir Lingaas; Asselbergs, Folkert W; Roden, Dan M; Darbar, Dawood; Pedersen, Terje Rolf; Sabatine, Marc S.; Willer, Cristen J.; Løchen, Maja-Lisa; Halldorsson, Bjarni V; Jonsdottir, Ingileif; Hveem, Kristian; Arnar, David O; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel F.; Holm, Hilma; Stefansson, Kari (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-12)
      Most sequence variants identified hitherto in genome-wide association studies (GWAS) of atrial fibrillation are common, non-coding variants associated with risk through unknown mechanisms. We performed a meta-analysis of GWAS of atrial fibrillation among 29,502 cases and 767,760 controls from Iceland and the UK Biobank with follow-up in samples from Norway and the US, focusing on low-frequency coding ...
    • Cross-sectional associations between accelerometry-measured physical activity, left atrial size, and indices of left ventricular diastolic dysfunction: The Tromsø Study 

      Heitmann, Kim Arne; Løchen, Maja-Lisa; Hopstock, Laila Arnesdatter; Stylidis, Michael; Welde, Boye; Schirmer, Henrik; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-31)
      Whereas left atrial (LA) enlargement is an independent predictor for adverse cardiovascular events and all-cause mortality, this is regarded a physiological adaption of exercise. Paradoxically, LA size in athletes may overlap the enlargement observed in patients with cardiac pathology. Current knowledge is mainly derived from studies of athletes, and little is known about cardiac adaptations to ...
    • Data from national health registers as endpoints for the Tromsø Study: Correctness and completeness of stroke diagnoses 

      Varmdal, Torunn; Løchen, Maja-Lisa; Wilsgaard, Tom; Njølstad, Inger; Nyrnes, Audhild; Grimsgaard, Sameline; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-14)
      Aim: To assess whether stroke diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for the Tromsø Study, a population-based epidemiological study.<p> <p>Method: Using the Tromsø Study Cardiovascular Disease Register for 2013–2014 as the gold standard, we calculated correctness (defined as positive predictive value, PPV) and ...
    • Data on gender contrasts in the risk of incident myocardial infarction by age. The Tromsø Study 1979–2012 

      Albrektsen, Grethe; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom; Njølstad, Inger; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-08)
      The data presented in this article relate to the research article entitled “Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979–2012” (Albrektsen et al., 2017) [1]. Data quantify the gender differences in the risk of myocardial infarction (MI) in terms of incidence rate ratios (IRR), in subgroups defined by serum lipids, ...
    • The DBP Phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study 

      Jorde, Rolf; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Joakimsen, Ragnar Martin; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-18)
      Background and Objective In addition to its role as a transport protein, the vitamin D binding protein (DBP) may also affect lipid metabolism, inflammation and carcinogenesis. There are three common variants of the DBP, Gc1s (1s), Gc1f (1f), Gc2 (2) that result in six common phenotypes (1s/1s, 1s/ 1f, 1s/2, 1f/1f, 1f/2, and 2/2). These phenotypes can be identified by genotyping for the two single ...
    • E. Sverre og medarbeidere svarer 

      Sverre, Elise Christine Bjørkholen; Halvorsen, Sigrun; Løchen, Maja-Lisa; Munkhaugen, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)
    • Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference 

      Schnabel, Renate B; Marinelli, Elena Andreassi; Arbelo, Elena; Boriani, Giuseppe; Boveda, Serge; Buckley, Claire M; Camm, A. John; Casadei, Barbara; Chua, Winnie; Dagres, Nikolaos; De Melis, Mirko; Desteghe, Lien; Diederichsen, Søren Zöga; Duncker, David; Eckardt, Lars; Eisert, Christoph; Engler, Daniel; Fabritz, Larissa; Freedman, Ben; Gillet, Ludovic; Goette, Andreas; Guasch, Eduard; Svendsen, Jesper Hastrup; Hatem, Stphane N; Haeusler, Karl Georg; Healey, Jeff S; Heidbuchel, Hein; Hindricks, Gerhard; Hobbs, F. D. Richard; Hübner, Thomas; Kotecha, Dipak; Krekler, Michael; Leclercq, Christophe; Lewalter, Thorsten; Lin, Honghuang; Linz, Dominik; Lip, Gregory Y. H.; Løchen, Maja-Lisa; Lucassen, Wim; Malaczynska-Rajpold, Katarzyna; Massberg, Steffen; Merino, Jose L; Meyer, Ralf; Mont, Lluls; Myers, Michael C; Neubeck, Lis; Niiranen, Teemu; Oeff, Michael; Oldgren, Jonas; Potpara, Tatjana S; Psaroudakis, George; Pürerfellner, Helmut; Ravens, Ursula; Rienstra, Michiel; Rivard, Lena; Scherr, Daniel; Schotten, Ulrich; Shah, Dipen; Sinner, Moritz F; Smolnik, Rüdiger; Steinbeck, Gerhard; Steven, Daniel; Svennberg, Emma; Thomas, Dierk; True Hills, Mellanie; Van Gelder, Isabelle C; Vardar, Burcu; Palà, Elena; Wakili, Reza; Wegscheider, Karl; Wieloch, Mattias; Willems, Stephan; Witt, Henning; Ziegler, Andrd; Daniel Zink, Matthias; Kirchhof, Paulus (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-27)
      Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three ...
    • Effect of genetically low 25-hydroxyvitamin D on mortality risk: Mendelian randomization analysis in 3 large European cohorts 

      Aspelund, Thor; Grübler, Martin R.; Smith, Albert V.; Gudmundsson, Elias F.; Keppel, Martin; Cotch, Mary Frances; Harris, Tamara B.; Jorde, Rolf; Grimnes, Guri; Joakimsen, Ragnar Martin; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; März, Winfried; Kleber, Marcus E.; Tomaschitz, Andreas; Grove-Laugesen, Diana; Rejnmark, Lars; Swart, Karin M.A.; Brouwer, Ingeborg A.; Lips, Paul; van Schoor, Natasja M.; Sempos, Christopher T.; Durazo-Arvizu, Ramón A.; Škrabáková, Zuzana; Dowling, Kirsten G.; Cashman, Kevin D.; Kiely, Mairead; Pilz, Stefan; Gudnason, Vilmundur; Eiríksdóttir, Gudny (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-02)
      The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D ...
    • Electronic cigarettes and health with special focus on cardiovascular effects: position paper of the European Association of Preventive Cardiology (EAPC) 

      Kavousi, Maryam; Pisinger, Charlotta; Barthelemy, Jean-Claude; Smedt, Delphine De; Koskinas, Konstantinos; Marques-Vidal, Pedro; Panagiotakos, Demosthenes; Prescott, Eva Bossano; Tiberi, Monica; Vassiliou, Vassilios S; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-17)
      Background - Tobacco use is the single largest preventable risk factor for premature death of non-communicable diseases and the second leading cause of cardiovascular disease. In response to the harmful effects of tobacco smoking, the use of electronic cigarettes (e-cigarettes) has emerged and gained significant popularity over the past 15 years. E-cigarettes are promoted as safe alternatives for ...
    • Epidemiologisk atrieflimmerforskning i Tromsøundersøkelsen. Hva har vi lært? 

      Løchen, Maja-Lisa; Tiwari, Sweta (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      Tromsøundersøkelsen er Norges lengste, mest omfattende og best besøkte epidemiologiske befolkningsundersøkelse gjennom mer enn 40 år. Forskningen har gitt oss viktig kunnskap om helse og sykdom og bidrar til bedre pasientbehandling, nasjonalt og internasjonalt. Atrieflimmerforskning har bidratt til ny kunnskap om utbredelse og risikofaktorer.
    • Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population 

      Eriksen, Bjørn Odvar; Løchen, Maja-Lisa; Arntzen, Kjell Arne; Bertelsen, Geir; Eilertsen, Britt-Ann; Hanno, Therese von; Herder, Marit; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Melsom, Toralf; Njølstad, Inger; Solbu, Marit Dahl; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
      Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ...
    • Ethnic difference in the prevalence of angina pectoris in Sami and non-Sami populations: the SAMINOR study 

      Eliassen, Bent-Martin; Graff-Iversen, Sidsel; Melhus, Marita; Løchen, Maja-Lisa; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Objective: To assess the population burden of angina pectoris symptoms (APS), self-reported angina and a combination of these, and explore potential ethnic disparity in their patterns. If differences in APS were found between Sami and non-Sami populations, we aimed at evaluating the role of established cardiovascular risk factors as mediating factors. Design: Cross-sectional population-based ...
    • Evaluation of Synthetic Categorical Data Generation Techniques for Predicting Cardiovascular Diseases and Post-Hoc Interpretability of the Risk Factors 

      García-Vicente, Clara; Chushig-Muzo, David; Mora-Jiménez, Inmaculada; Fabelo, Himar; Gram, Inger Torhild; Løchen, Maja-Lisa; Granja, Conceição; Soguero-Ruiz, Cristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-23)
      Machine Learning (ML) methods have become important for enhancing the performance of decision-support predictive models. However, class imbalance is one of the main challenges for developing ML models, because it may bias the learning process and the model generalization ability. In this paper, we consider oversampling methods for generating synthetic categorical clinical data aiming to improve the ...
    • Factors associated with predictors of smoking cessation from a Norwegian internet-based smoking cessation intervention study 

      Gram, Inger Torhild; Antypas, Konstantinos; Wangberg, Silje C; Løchen, Maja-Lisa; Larbi, Dillys (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-31)
      Introduction: We examined if we could identify predictors for smoking cessation at six months post cessation, among smokers enrolled in a large Norwegian populationbased intervention study.<p> <p>Methods: We followed 4333 (72.1% women) smokers who enrolled in an internetbased smoking cessation intervention during 2010–2012. The baseline questionnaire collected information on sociodemographic and ...
    • Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014 

      Sagelv, Edvard Hamnvik; Casolo, Andrea; Eggen, Anne Elise; Heitmann, Kim Arne; Johansen, Kristoffer Robin; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Morseth, Bente; Njølstad, Inger; Osborne, John Owen; Hagerupsen, Karianne; Pedersen, Sigurd; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-06)
      Objective - To examine the dose-response association between estimated cardiorespiratory fitness (eCRF) and risk of myocardial infarction (MI).<p> <p>Patients and Methods - Adults who attended Tromsø Study surveys 4-6 (Janurary 1,1994-December 20, 2008) with no previous cardiovascular disease were followed up through December 31, 2014 for incident MI. Associations were examined using restricted ...