Objectives - To examine whether moderate-to-vigorous physical activity (MVPA) modifies the association between sedentary time and mortality and vice versa, and estimate the joint associations of MVPA and sedentary time on mortality risk.<p> <p>Methods - This study involved individual participant data analysis of four prospective cohort studies (Norway, Sweden, USA, baseline: 2003–2016, 11 989 ...

Background - New‐generation drug‐eluting stents (DES) reduce target‐vessel revascularization compared with bare‐metal stents (BMS), and recent data suggest that DES have the potential to decrease the risk of myocardial infarction and cardiovascular mortality. We evaluated the treatment effect of DES versus BMS according to the target artery (left anterior descending [LAD] and/or left main [LM] versus ...

Early sexual behaviour has been shown to differ significantly between genders, but few studies have addressed this topic to explain the commonly observed differences in chlamydia rates between adolescent girls and boys. Our study aimed to determine chlamydia prevalence in adolescents aged 15–20 years in a high-incidence area in Norway, and to identify gender-specific early sexual behaviours associated ...

Objective To assess the efficacy of caudal epidural steroid or saline injection in chronic lumbar radiculopathy in the short (6 weeks), intermediate (12 weeks), and long term (52 weeks).<p> <p>Design Multicentre, blinded, randomised controlled trial. <p>Setting Outpatient multidisciplinary back clinics of five Norwegian hospitals. <p>Participants Between October 2005 and February 2009, 461 ...

The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D ...

Background Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with risk of anastomotic leak (AL). However, concomitant use of other drugs could infer a bias in risk assessment. Thus, we aimed to interrogate the risk of AL associated with NSAIDs and steroids used perioperatively. Methods This study includes a consecutive series of patients having surgery involving ...

Importance - Topical vitamin D analogues are routine treatment for psoriasis, but the effect of oral supplementation has not been established.<p> <p>Objective - To examine the effect of vitamin D supplementation on psoriasis severity throughout the winter.<p> <p>Design, Setting, and Participants - This randomized, double-blind placebo-controlled clinical trial with 2 parallel groups was performed ...

Background Questions remain concerning to what extent age and sex may modify the suggested association between psoriasis and the metabolic syndrome in the general population. Objectives To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort by age and sex.<p> <p>Methods A cross-sectional study including 10 521 participants aged 30–79 ...

Objectives  To investigate the association between the geometrical properties of episiotomy and obstetric anal sphincter injuries (OASIS) because episiotomies angled at 40–60° are associated with fewer OASIS than episiotomies with more acute angles. Design  Case–control study. Setting  University Hospital of North Norway, Tromsø and Nordland Hospital, Bodø, Norway. Sample  Seventy-four women ...

<i>Background</i> - Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarkers of cardiac damage and inflammation.<p><p> <i>Methods and Results</i> - The Know Your ...