ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraakEnglish 
    • EnglishEnglish
    • norsknorsk
  • Administration/UB
View Item 
  •   Home
  • Det helsevitenskapelige fakultet
  • Institutt for samfunnsmedisin
  • Artikler, rapporter og annet (samfunnsmedisin)
  • View Item
  •   Home
  • Det helsevitenskapelige fakultet
  • Institutt for samfunnsmedisin
  • Artikler, rapporter og annet (samfunnsmedisin)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Evidence for a direct harmful effect of alcohol on myocardial health: A large cross-sectional study of consumption patterns and cardiovascular disease risk biomarkers from northwest Russia, 2015 to 2017

Permanent link
https://hdl.handle.net/10037/18480
DOI
https://doi.org/10.1161/JAHA.119.014491
Thumbnail
View/Open
article.pdf (425.7Kb)
Published version (PDF)
Date
2019-12-18
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Iakunchykova, Olena; Averina, Maria; Kudryavtsev, Alexander V; Wilsgaard, Tom; Soloviev, Andrey; Schirmer, Henrik; Cook, Sarah Anne; Leon, David Adrew
Abstract
Background - Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarkers of cardiac damage and inflammation.

Methods and Results - The Know Your Heart study recruited a random sample of 2479 participants from the population of northwest Russia (general population) plus 278 patients (narcology clinic subsample) with alcohol problems. The general population sample was categorized into harmful drinkers, hazardous drinkers, nonproblem drinkers, and nondrinkers, according to self‐reported level of alcohol consumption, whereas the narcology clinic sample was treated as the separate group in the analysis. Measurements were made of the following: (1) high‐sensitivity cardiac troponin T, (2) NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), and (3) hsCRP (high‐sensitivity C‐reactive protein). The narcology clinic subsample had the most extreme drinking pattern and the highest levels of all 3 biomarkers relative to nonproblem drinkers in the general population: high‐sensitivity cardiac troponin T was elevated by 10.3% (95% CI, 3.7%–17.4%), NT‐proBNP by 46.7% (95% CI, 26.8%–69.8%), and hsCRP by 69.2% (95% CI, 43%–100%). In the general population sample, NT‐proBNP was 31.5% (95% CI, 3.4%–67.2%) higher among harmful drinkers compared with nonproblem drinkers. Overall, NT‐proBNP and hsCRP increased with increasing intensity of alcohol exposure (test of trend P<0.001).

Conclusions - These results support the hypothesis that heavy alcohol drinking has an adverse effect on cardiac structure and function that may not be driven by atherosclerosis.

Is part of
Iakunchykova, O. (2021). A biomarker approach to explain high cardiovascular disease burden in Russia: insights from population-based studies in Russia and Norway. (Doctoral thesis). https://hdl.handle.net/10037/20633.
Publisher
Wiley Open Access
Citation
Iakunchykova O, Averina M, Kudryavtsev AV, Wilsgaard T, Soloviev A, Schirmer H, Cook SA, Leon DA. Evidence for a direct harmful effect of alcohol on myocardial health: A large cross-sectional study of consumption patterns and cardiovascular disease risk biomarkers from northwest Russia, 2015 to 2017. Journal of the American Heart Association. 2020;9(1):1-17
Metadata
Show full item record
Collections
  • Artikler, rapporter og annet (samfunnsmedisin) [1515]
Copyright 2019 The Author(s)

Browse

Browse all of MuninCommunities & CollectionsAuthor listTitlesBy Issue DateBrowse this CollectionAuthor listTitlesBy Issue Date
Login

Statistics

View Usage Statistics
UiT

Munin is powered by DSpace

UiT The Arctic University of Norway
The University Library
uit.no/ub - munin@ub.uit.no

Accessibility statement (Norwegian only)