Munin: Recent submissions
Now showing items 21401-21420 of 37057
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Bone matrix levels of Dickkopf and sclerostin are positively correlated with bone mass and strength in postmenopausal osteoporosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-03)Wnt signaling plays a pivotal role in maintaining bone mass. Secreted pathway modulators such as sclerostin (SOST) and Dickkopfs (DKKs) may influence bone mass inhibiting the canonical Wnt pathway. We evaluated whether bone protein content of secreted Wnt antagonists is related to age, bone mass, and strength in postmenopausal osteoporosis. We measured cortical and trabecular bone contents of SOST ... -
Transkateter aorta ventil implantasjon. En retrospektiv kvalitetssikringsoppgave
(Master thesis; Mastergradsoppgave, 2017-09-17)Bakgrunn: Aortastenose er en sykdom som har økt forekomst med økende alder, og alvorlig symptomgivende aortastenose har en dyster prognose. Uten behandling er median overlevelsestid 2 år dersom pasienten utvikler hjertesvikt. Tidligere ble denne pasientgruppen operert med åpen hjertekirurgi, men mange fikk ikke tilbud om behandling grunnet omfattende komorbiditet og høy-risiko. Dermed oppstod behovet ... -
Drones and marine mammals in Svalbard
(Master thesis; Mastergradsoppgave, 2019-07-15)The impact of Remote Piloted Aircraft Systems (RPAS, or drones) on marine mammals remains poorly documented despite their increasing use by hobbyists and scientists. In the High-Arctic Archipelago of Svalbard, where marine mammals are facing increasing pressure from the coupled effects of climate modification and an expanding tourism industry, the use of RPAS remains largely unregulated to date. In ... -
A patch of Calanus finmarchicus in the Lofoten-Vesterålen Region. Characteristics and determining factors
(Master thesis; Mastergradsoppgave, 2019-05-16)Zooplankton patchiness has been documented in many shelf areas and is of vital importance for understanding predator-prey relationships in pelagic marine systems. By combining hydrographic, acoustic and net data collected in spring 2017, we present a detailed understanding of the extent of this phenomenon in the Lofoten-Vesterålen region. Such patches are of potential interest not only for zooplankton ... -
Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-01)Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients have non-infectious inflammatory and autoimmune complications, associated with systemic immune activation. Our aim was to explore if HDL, known to have anti-inflammatory properties, ... -
Critical Digital Literacy: Technology in Education Beyond Issues of User Competence and Labour-Market Qualifications
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-26)The present contribution conducts an intervention in the study and practice of digital and media literacy. After reviewing key tenets of recent debates, I advance a specific under- standing of the concept – critical digital literacy – that, as I argue, comprehensively addresses issues of knowledge, competencies, and skills in relation to digital technologies. In particular, I posit that critical ... -
Language mixing within verbs and nouns in American Norwegian
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-29)This paper presents case-studies of language mixing within verbs and nouns in the heritage language American Norwegian, which refers to varieties spoken by Norwegian immigrants to the US and their descendants. The paper builds on data from the newly established <i>Corpus of American Norwegian Speech</i> and argues in favor of an exoskeletal approach to language mixing. This approach distinguishes ... -
Epistemology of epidemiology: The case of Ungdata
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)One of the most significant epidemiological tools for the perceived truth about contemporary Norwegian youth is in Ungdata, Youth Data. This is a continuous online-based survey grounded upon several and varying investigations of youth in Norwegian high schools, now extending to primary schools as well. The knowledge bases, epidemiological practices, technicalities, economic premises for the work and ... -
Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-12)Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the ... -
Do Russian paucal numerals govern the genitive? Evidence from stress placement
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-17)A long-standing issue in Russian linguistics concerns the noun in paucal constructions like dva goroda ‘two cities’. Is goroda the genitive singular of gorod, a separate ‘numerative case form’, or a ‘paucal number’? Although stress has figured prominently in the debate, corpus data and informant data regarding stress have received little attention. Based on the accentuated part of the Russian National ... -
Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)<i>Aims</i> - The risk of gestational diabetes mellitus (GDM) is increased in overweight and obese women potentially involving secreted mediators from adipose tissue. Our main aim was to evaluate if circulating adipokines and monocyte/macrophage markers were dysregulated in GDM and the influence body mass and indices of glucose metabolism had on this association. We further explored if early detection ... -
Radar studies of ionospheric dusty plasma phenomena
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-17)We discuss the influence of charged dust on radar observations in the Earth ionosphere. This region in the upper Earth atmosphere can be described as a partially ionized, low‐temperature plasma. Plasma parameters vary by orders of magnitude spatially and in time. Dust particles influence the charge balance, in some cases dusty plasma condition is met. The polar mesospheric echoes are an example of ... -
In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-04)Molting is an essential process in the life cycle of arthropods and is regulated by complex neuroendocrine pathways where activation of the ecdysone receptor (EcR) plays a major role. The EcR forms a non-covalent heterodimer with the ultraspiracle protein (USP) when activated by endogenous ecdysteroids, but can also be activated by several insecticides and other environmental chemicals. Environmental ... -
Blinding is compromised for transcranial direct current stimulation at 1 mA for 20 min in young healthy adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-19)Transcranial direct current stimulation (tDCS) is a non‐invasive brain stimulation method that is frequently used to study cortical excitability changes and their impact on cognitive functions in humans. While most stimulators are capable of operating in double‐blind mode, the amount of discomfort experienced during tDCS may break blinding. Therefore, specifically designed sham stimulation protocols ... -
Solar Flare Effects on 150-km Echoes Observed Over Jicamarca: WACCM-X Simulations
(Journal article; Tidsskriftartikkel, 2019-09-11)Jicamarca Radio Observatory observations and Whole Atmosphere Community Climate Model with thermosphere‐ionosphere eXtension (WACCM‐X) simulations are used to investigate the effects of the September 7, 2005 X‐17 solar flare on 150‐km echoes, electron densities, and vertical plasma drifts. The solar flare produces a remarkably similar response in the observed 150‐km echoes and simulated electron ... -
Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-17)The gene encoding MG Orn has been identified from a metagenomic library created from the intertidal zone in Svalbard and encodes a protein of 184 amino acid residues. The <i>mg orn</i> gene has been cloned, recombinantly expressed in <i>Escherichia coli</i>, and purified to homogeneity. Biochemical characterization of the enzyme showed that it efficiently degrades short RNA oligonucleotide substrates ... -
Domestic cats (Felis catus) in Denmark have increased significantly in size since the Viking Age
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-03)The earliest finds of domestic cat in Denmark date back to the Roman Iron Age (c. 1–375 AD). Initially, cats occurred sparsely and only from the Viking Age (c. 850–1050 AD) did they become more frequent in numbers, though primarily in urban contexts and in connection with fur production. In medieval times, cats became beasts of pest control in rural settlements, manorial estates as well as in the ... -
Valuing blue carbon changes in the Arctic ocean
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-25)The ocean capacity to store carbon is crucial, and currently absorbs about 25% CO<sub>2</sub> supply to the atmosphere. The ability to store carbon has an economic value, but such estimates are not common for ocean environments, and not yet estimated for the Arctic Ocean. With the severe climatic changes in the Arctic Ocean, impacting sea ice and potentially the vertical carbon transport mechanisms, ... -
Global warming leads to Early Triassic nutrient stress across northern Pangea
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-30)The largest extinction in Earth history, in the latest Permian, was followed throughout most of the Early Triassic by a prolonged period of ecologic recovery. What factors delayed biotic recovery are still under debate and partly revolve around impacts of global warming on primary marine productivity. We examined N isotope records from the Festningen section on Spitsbergen, Arctic Norway, to examine ... -
In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-05)<i>Background</i>: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD).<p> <p><i>Methods/design</i>: This pilot study includes pregnant women at high risk (smoking at ...