Now showing items 1-20 of 15884

    • Loss of life years due to unavailable helicopter emergency medical service: a single base study from a rural area of Norway 

      Zakariassen, Erik; Østerås, Øyvind; Nystøyl, Dag Ståle; Breidablik, Hans Johan; Solheim, Eivind; Brattebø, Guttorm; Ellensen, Vegard Skalstad; Hoff, Jana Midelfart; Hordnes, Knut; Aksnes, Arne; Heltne, Jon-Kenneth; Hunskaar, Steinar; Hotvedt, Ragnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-29)
      <i>Background</i>: Despite the potential benefits of physician-staffed Helicopter Emergency Medical Service (HEMS), many dispatches to primary HEMS missions in Norway are cancelled before patient encounter. Information is sparse regarding the health consequences when medically indicated HEMS missions are cancelled and the patients are treated by a GP and ambulance staff only. We aimed to estimate ...
    • Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 

      Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
      <p><i>Introduction - </i>Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currently undergoing clinical trials in several human malignancies, including triple-negative breast cancer ...
    • The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could Be 

      Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-15)
      This study aims to understand what lupus nephritis is, its origin, clinical context, and its pathogenesis. Truly, we encounter many conceptual and immanent tribulations in our attempts to search for the pathogenesis of this disease—and how to explain its assumed link to SLE. Central in the present landscape stay a short history of the early studies that substantiated the structures of isolated or ...
    • De yngste barna som vegfarere i barnehagen 

      Sverdrup, Toril; Myrstad, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-04)
      Artikkelen fokuserer på de yngste barnas læringsprosesser gjennom deres involvering og engasjement med sosiale og fysiske omgivelser i barnehagen. Det løftes fram hvordan barnekropper i bevegelse er kilde for erkjennelse og læring. Som utgangspunkt for analysen har vi valgt to eksempler fra barns aktivitet i barnehagens uteområde. Forsker har vært tilstede som deltakende observatør, og inngått som ...
    • A new method of inferring the size, number density, and charge of mesospheric dust from its in situ collection by the DUSTY probe 

      Havnes, Ove; Antonsen, Tarjei; Baumgarten, Gerd; Hartquist, Thomas W.; Biebricher, Alexander; Fredriksen, Åshild; Friedrich, Martin; Hedin, Jonas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-15)
      <p>We present a new method of analyzing measurements of mesospheric dust made with DUSTY rocket-borne Faraday cup probes. It can yield the variation in fundamental dust parameters through a mesospheric cloud with an altitude resolution down to 10 cm or less if plasma probes give the plasma density variations with similar height resolution. A DUSTY probe was the first probe that unambiguously detected ...
    • Do Various Respirator Models Fit the Workers in the Norwegian Smelting Industry? 

      Føreland, Solveig; Robertsen, Øystein; Hegseth, Marit Nøst (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-19)
      <p><i>Background - </i>Respirator fit testing is a method to assess if the respirator provides an adequate face seal for the worker. <p><i>Methods - </i>Workers from four Norwegian smelters were invited to participate in the study, and 701 respirator fit tests were performed on 127 workers. Fourteen respirator models were included: one FFABE1P3 and 11 FFP3 respirator models produced in one size and ...
    • The Neglected Marine Fungi, Sensu stricto, and Their Isolation for Natural Products’ Discovery 

      Overy, David P.; Rämä, Teppo; Oosterhuis, Rylee; Walker, Allison K.; Pang, Ka-Lai (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-10)
      Despite the rapid development of molecular techniques relevant for natural product research, culture isolates remain the primary source from which natural products chemists discover and obtain new molecules from microbial sources. Techniques for obtaining and identifying microbial isolates (such as filamentous fungi) are thus of crucial importance for a successful natural products’ discovery program. ...
    • Enhancing Urban Encounters: The Transformative Powers of Creative Integration Initiatives 

      Førde, Anniken (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-24)
      Sustainable cites require the capacity to live with difference. In a world of increased mobility and migration, our cities become more and more diversified. While national discourses on diversity are often problem-focused, social initiatives are emerging in diverse cities addressing the positive potential of the city as a cross-cultural meeting place. In Norway, such initiatives have increased in ...
    • Weather situation during observed ship-icing events off the coast of Northern Norway and the Svalbard archipelago 

      Samuelsen, Eirik Mikal; Graversen, Rune (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-19)
      Ship icing may lead the ship and crew in great jeopardy. Usually, predictions of such ice build-up are based on the modelling of the heat fluxes capable of freezing sea water originated from wave-ship interactions. This study, on the other hand, follows a different and more general approach by investigating the relationship between the weather situation and icing both using observed parameters from ...
    • Automatic Detection of Small Icebergs in Fast Ice Using Satellite Wide-Swath SAR Images 

      Soldal, Ingri Halland; Dierking, Wolfgang Fritz Otto; Korosov, Anton; Marino, Armando (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-03)
      Automatic detection of icebergs in satellite images is regarded a useful tool to provide information necessary for safety in Arctic shipping or operations over large ocean areas in near-real time. In this work, we investigated the feasibility of automatic iceberg detection in Sentinel-1 Extra Wide Swath (EWS) SAR images which follow the preferred image mode in operational ice charting. As test region, ...
    • Impact of assimilating sea ice concentration, sea ice thickness and snow depth in a coupled ocean-sea ice modelling system 

      Fritzner, Sindre Markus; Graversen, Rune; Christensen, Kai Håkon; Rostosky, Philip; Wang, Keguang (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-08)
      The accuracy of the initial state is very important for the quality of a forecast, and data assimilation is crucial for obtaining the best-possible initial state. For many years, sea-ice concentration was the only parameter used for assimilation into numerical sea-ice models. Sea-ice concentration can easily be observed by satellites, and satellite observations provide a full Arctic coverage. During ...
    • Hva mener du om genmodifisert mat? 

      Bakkelund, Torill Pauline Blix (Others; Andre, 2019-09-22)
    • Postprandial changes in gene expression of cholesterol influx and efflux mediators after intake of SFA compared to n-6 PUFA in subjects with and without familial hypercholesterolemia: secondary outcomes of a randomized controlled trial 

      Øyri, Linn Kristin Lie; Narverud, Ingunn; Bogsrud, Martin Prøven; Hansson, Patrik; Leder, Lena; Byfuglien, Marte Gjeitung; Veierød, Marit Bragelien; Thoresen, Magne; Ulven, Stine Marie; Holven, Kirsten Bjørklund (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-13)
      The long-term cholesterol-lowering effect of replacing intake of SFA with PUFA is well established, but has not been fully explained mechanistically. We examined the postprandial response of meals with different fat quality on expression of lipid genes in peripheral blood mononuclear cells (PBMC) in subjects with and without familial hypercholesterolaemia (FH). Thirteen subjects with FH (who had ...
    • Catalytic Intermolecular Functionalization of Benzimidazoles 

      Hansen, Jørn H; Fjellaksel, Richard (Peer reviewed; Chapter; Bokkapittel, 2019-06-25)
      This chapter describes contemporary strategies for selective catalytic intermolecular functionalization of the benzimidazole scaffold. Functionalization at nitrogen and position C-2 is well developed employing copper, palladium, rhodium, nickel, and cobalt catalysis. Direct CH activation is the predominant approach to C-2 functionalization. Nickel-based catalysts can activate C—O bonds in conjunction ...
    • A Political Conception of Pandemics and Epidemics in Africa 

      Abumere, Frank Aragbonfoh (Chapter; Bokkapittel; Preprint; Manuskript, 2019-08-17)
      This chapter is concerned with extra-biological, extra-medical or extra-health factors, namely: actions and inactions (commissions and omissions) that are morally unjust – that is, which are moral injustice – which ultimately cause, enable or contribute to pandemics and epidemics in Africa. Therefore, although this chapter is dealing with health, the framework of the chapter is neither biological ...
    • Early maladaptive schemas as predictors of maternal bonding to the unborn child 

      Nordahl, Dag; Høifødt, Ragnhild Sørensen; Bohne, Agnes; Landsem, Inger Pauline; Wang, Catharina Elisabeth Arfwedson; Thimm, Jens (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-11)
      <p><i>Background - </i>The quality of an expectant mother’s bonding to the fetus has been shown to be associated with important developmental outcomes. Previous studies suggest that bonding quality is predicted by, for example, social support, psychological well-being, and depression. However, little is known regarding the role of maternal cognition in maternal-fetal bonding. Early maladaptive schemas ...
    • Clinical Course in Chronic Subdural Hematoma Patients Aged 18–49 Compared to Patients 50 Years and Above: A Multicenter Study and Meta-Analysis 

      Bartek, Jiri; Sjåvik, Kristin; Dhawan, Sanjay; Sagberg, Lisa Millgård; Kristiansson, Helena; Ståhl, Fredrik; Förander, Petter; Chen, Clark C.; Jakola, Asgeir Store (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-05)
      <p><i>Objective - </i>Chronic Subdural Hematoma (cSDH) is primarily a disease of elderly, and is rare in patients <50 years, and this may in part be related to the increased brain atrophy from 50 years of age. This fact may also influence clinical presentation and outcome. The aim of this study was to study the clinical course with emphasis on clinical presentation of cSDH patients in the young (<50 ...
    • The effect of white matter hyperintensities on regional brain volumes and white matter microstructure, a population-based study in HUNT 

      Vangberg, Torgil Riise; Eikenes, Live; Håberg, Asta K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-04)
      Even though age-related white matter hyperintensities (WMH) begin to emerge in middle age, their effect on brain micro- and macrostructure in this age group is not fully elucidated. We have examined how presence of WMH and load of WMH affect regional brain volumes and microstructure in a validated, representative general population sample of 873 individuals between 50 and 66 years. Presence of WMH ...
    • Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid 

      Sistiaga, Manu Berrondo; Herrmann, Bent; Larsen, Roger B.; Brinkhof, Jesse (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-12)
      Shrimp trawlers in the Barents Sea use a Nordmøre sorting grid ahead of a small-mesh codend to avoid bycatch while catching shrimps efficiently. However, small fish can still pass through the grid to enter the codend, which increases their risk of being retained. In this study, we quantified the selectivity of a standard Nordmøre grid used together with one of two different codend designs, namely a ...
    • Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-17)
      Common variable immunodeficiency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic inflammation and ten “key” bacteria that capture the gut dysbiosis (dysbiosis index) in CVID. Rifaximin is a broad-spectrum non-absorbable antibiotic known to reduce gut leakage (lipopolysaccharides, LPS) in liver ...