Viser treff 21-40 av 14530

    • Patterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabwe 

      Sovershaeva, Evgeniya; Shamu, Tinei; Wilsgaard, Tom; Bandason, Tsitsi; Flægstad, Trond; Katzenstein, David; Ferrand, Rashida A.; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-31)
      <i>Objective</i>: To investigate the incidence and predictors of viraemia among individuals on antiretroviral therapy (ART) in Harare, Zimbabwe.<p> <p><i>Methods</i>: Children (0–19 years) and adults (>19 years) starting ART between 2013 and 2015 were followed for a median of 2.8 and 2.7 years, respectively. The incidence rates of virological failure (VF), low-level viraemia (LLV), and viral ...
    • Functional roles and redundancy of demersal Barents Sea fish: Ecological implications of environmental change 

      Aune, Magnus; Aschan, Michaela; Greenacre, Michael; Dolgov, Andrey V.; Fossheim, Maria; Primicerio, Raul (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-21)
      When facing environmental change and intensified anthropogenic impact on marine ecosystems, extensive knowledge of how these systems are functioning is required in order to manage them properly. However, in high-latitude ecosystems, where climate change is expected to have substantial ecological impact, the ecosystem functions of biological species have received little attention, partly due to the ...
    • External damage to trawl-caught Northeast arctic cod (Gadus morhua): Effect of codend design 

      Tveit, Guro Møen; Sistiaga, Manu Berrondo; Herrmann, Bent; Brinkhof, Jesse (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)
      The purpose of this study was to investigate the extent of external damage (gear marks, pressure injuries, ecchymosis and skin abrasion) present on trawl-caught cod (Gadus morhua) and to examine whether the extent of damage could be reduced by introducing changes in the gear. We tested whether changing the 2-panel knotted codend used by the Norwegian trawler fleet operating in the Barents Sea today ...
    • Progesterone receptors in prostate cancer: Progesterone receptor B is the isoform associated with disease progression 

      Grindstad, Thea K.W.; Richardsen, Elin; Andersen, Sigve; Skjefstad, Kaja Konstanse; Rakaee, Mehrdad; Dønnem, Tom; Ness, Nora; Nordby, Yngve; Bremnes, Roy M.; Al-Saad, Samer; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-27)
      The role of steroid hormones in carcinogenesis of the prostate is to some extent unraveled thorough the effect of androgen deprivation therapy on prostate cancer (PCa) progression. Other members of the steroid hormone family, such as progesterone, are also implicated in PCa, but progesterone’s role remains undefined. This study aimed to examine the distribution of progesterone receptor isoforms ...
    • Reflection groups, arrangements, and invariant real varieties 

      Friedl, Tobias; Riener, Cordian; Sanyal, Raman (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-18)
      Let <i>X</i> be a nonempty real variety that is invariant under the action of a reflection group <i>G</i>. We conjecture that if <i>X</i> is defined in terms of the first <i>k</i> basic invariants of <i>G</i> (ordered by degree), then <i>X</i> meets a <i>k</i>-dimensional flat of the associated reflection arrangement. We prove this conjecture for the infinite types, reflection groups of rank at most ...
    • DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases 

      Williamson, Adele Kim; Grgic, Miriam; Leiros, Hanna-Kirsti S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-11)
      DNA ligases join breaks in the phosphodiester backbone of DNA by catalysing the formation of bonds between opposing 5′P and 3′OH ends in an adenylation-dependent manner. Catalysis is accompanied by reorientation of two core domains to provide access to the active site for cofactor utilization and enable substrate binding and product release. The general paradigm is that DNA ligases engage their DNA ...
    • Evaluation of feature ranking and regression methods for oceanic chlorophyll-a estimation 

      Blix, Katalin; Eltoft, Torbjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
      This paper evaluates two alternative regression techniques for oceanic chlorophyll-a (Chl-a) content estimation. One of the investigated methodologies is the recently introduced Gaussian process regression (GPR) model. We explore two feature ranking methods derived for the GPR model, namely sensitivity analysis (SA) and automatic relevance determination (ARD). We also investigate a second ...
    • The Role of Estrogen Receptor β (ERβ) in the Establishment of Hierarchical Social Relationships in Male Mice 

      Nakata, Mariko; Ågmo, Anders j; Satoshi, Shoko; Ogawa, Sonoko (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-22)
      Acquisition of social dominance is important for social species including mice, for preferential access to foods and mates. Male mice establish social rank through agonistic behaviors, which are regulated by gonadal steroid hormone, testosterone, as its original form and aromatized form. It is well known that estrogen receptors (ERs), particularly ER α (ERα), mediate effects of aromatized testosterone, ...
    • On the Isotypic Decomposition of Cohomology Modules of Symmetric Semi-algebraic Sets: Polynomial Bounds on Multiplicities 

      Basu, Saugata; Riener, Cordian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-30)
      We consider symmetric (under the action of products of finite symmetric groups) real algebraic varieties and semi-algebraic sets, as well as symmetric complex varieties in affine and projective spaces, defined by polynomials of degrees bounded by a fixed constant <i>d</i>. We prove that if a Specht module, S<sup>λ</sup>⁠, appears with positive multiplicity in the isotypic decomposition of the ...
    • Making New Health Services Work: Nurse Leaders as Facilitators of Service Development in Rural Emergency Services 

      Hjertstrøm, Helle Kise; Obstfelder, Aud; Norbye, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-27)
      Nurse leaders in middle management positions in Norway and other Western countries perform additional new tasks due to high demands for quality and efficacy in healthcare services. These nurses are increasingly becoming responsible for service development and innovation in addition to their traditional leadership and management roles. This article analyses two Norwegian nurse leaders efforts in ...
    • On the equivariant Betti numbers of symmetric definable sets: vanishing, bounds and algorithms 

      Basu, Saugata; Riener, Cordian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-02)
      Let R be a real closed field. We prove that for any fixed <i>d</i>, the equivariant rational cohomology groups of closed symmetric semi-algebraic subsets of R<sup><i>k</i></sup> defined by polynomials of degrees bounded by <i>d</i> vanishes in dimensions <i>d</i> and larger. This vanishing result is tight. Using a new geometric approach we also prove an upper bound of [mathematical formula] on the ...
    • Method for detection of leads from Sentinel-1 SAR images 

      Murashkin, Dmitrii; Spreen, Gunnar; Huntemann, Marcus; Dierking, Wolfgang Fritz Otto (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-05)
      The presence of leads with open water or thin ice is an important feature of the Arctic sea ice cover. Leads regulate the heat, gas and moisture fluxes between the ocean and atmosphere and are areas of high ice growth rates during periods of freezing conditions. Here, an algorithm providing an automatic lead detection based on synthetic aperture radar images is described that can be applied to a ...
    • Applying GRADE-CERQual to qualitative evidence synthesis findings–paper 7: understanding the potential impacts of dissemination bias 

      Booth, Andrew; Lewin, Simon Arnold; Glenton, Claire; Munthe-Kaas, Heather Menzies; Toews, Ingrid; Noyes, Jane; Rashidian, Arash; Berg, Rigmor; Nyakang’o, Brenda; Meerpohl, Jörg J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-25)
      <p><i>Background</i>: The GRADE-CERQual (Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group. The approach has been developed to support the use of findings from qualitative evidence syntheses in decision-making, including guideline development and policy formulation. ...
    • SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro 

      Tümmler, Conny; Dumitriu, Gianina; Wickström, Malin; Coopman, Peter; Valkov, Andrey Yurjevich; Kogner, Per; Johnsen, John Inge; Moens, Ugo; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-10)
      Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine kinase (SYK) has previously been identified as a promising drug target in various inflammatory diseases and cancers but has so far not ...
    • Assessing the performance of the BARCAST climate field reconstruction technique for a climate with long-range memory 

      Nilsen, Tine; Werner, Johannes; Divine, Dmitry V; Rypdal, Martin wibe (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-29)
      The skill of the state-of-the-art climate field reconstruction technique BARCAST (Bayesian Algorithm for Reconstructing Climate Anomalies in Space and Time) to reconstruct temperature with pronounced long-range memory (LRM) characteristics is tested. A novel technique for generating fields of target data has been developed and is used to provide ensembles of LRM stochastic processes with a prescribed ...
    • “Students can have a really powerful role…” Understanding Curriculum Transformation Within the Framework of Canon Critique and Critical Pedagogy 

      Mittner, Lilli (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-27)
      Educational practice needs to continuously update the curriculum in line with both current theoretical frameworks developed within academia and the lived reality of the coming generation. This article takes the student perspective on this issue, investigating a case from secondary music education in England. In 2015, Jessy McCabe initiated a successful campaign for the inclusion of women composers ...
    • Fra Potet til Klima. Mortalitetsfallet i Norge 

      Johansen, Marthe Gamlemoen (Master thesis; Mastergradsoppgave, 2018-11-07)
      I 1969 poengterte Michael Drake fallet i dødsraten som det avgjørende skillet i populasjonsutviklingen i Norge. Drake mente at det var bedre ernæring, og særlig poteten som var den avgjørende faktoren for mortalitetsfallet. Siden denne doktoravhandlingen ble avlagt har det blitt utført mange studier på både lokalt og nasjonalt nivå for å beskrive når mortalitetsfallet var, og hvilke faktorer som ...
    • Resolvent bounds for jump generators 

      Kondratiev, Yuri; Molchanov, Stanislav; Piatnitski, Andrey; Zhizhina, Elena (Journal article; Peer reviewed; Tidsskriftartikkel, 2016-12-02)
      The paper deals with jump generators with a convolution kernel. Assuming that the kernel decays either exponentially or polynomially, we prove a number of lower and upper bounds for the resolvent of such operators. In particular we focus on sharp estimates of the resolvent kernel for small values of the spectral parameter. We consider two applications of these results. First we obtain pointwise ...
    • The Untouchable Nature of the ‘EU Seal Regime’— Is the European Union Liable for the Damages Suffered by the Canadian Inuit Due to the Violation of WTO Law in EC—Seal Products? 

      Hennig, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-12)
      In this article, the author assesses whether Canadian Inuit sealers, who have suffered economic damage in the wake of the introduction of the European Union (EU) ban on seal products, can bring an action for damages against the EU before the European Court of Justice. The author reviews why the EU ban on seal hunting violates World Trade Office (WTO) law and discusses if, and why, Canadian Inuit ...
    • Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart 

      Pedersen, Tina Myhre; Boardman, Neoma; Hafstad, Anne Dragøy; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
      Although murine models for studying the development of cardiac dysfunction in diabetes mellitus are well established, their reported cardiac phenotypes vary. These reported divergences may, in addition to the severity of different models, also be linked to the methods used for cardiac functional assessment. In the present study, we examined the functional changes using conventional transthoracic ...