Cyclic peptides are a promising class of compounds for next-generation antibiotics as they may provide new ways of limiting antibiotic resistance development. Although their cyclic structure will introduce some rigidity, their conformational space is large and they usually have multiple chiral centers that give rise to a wide range of possible stereoisomers. Chiroptical spectroscopies such as ...

The study of the brains’ oscillatory activity has been a standard technique to gain insights into human neurocognition for a relatively long time. However, as a complementary analysis to ERPs, only very recently has it been utilized to study bilingualism and its neural underpinnings. Here, we provide a theoretical and methodological starter for scientists in the (psycho) linguistics and neurocognition ...

Background: Etanercept (ETN) and adalimumab (ADA) are considered equally efective biologicals in the treat‑ ment of arthritis in juvenile idiopathic arthritis (JIA) but no studies have compared their impact on patient-reported well-being. The objective of this study was to determine whether ETN and ADA have a diferential efect on patientreported well-being in non-systemic JIA using real-world ...

Background - Middle managers play a key role in promoting a caring culture in nursing homes. However, there is limited knowledge about middle managers’ inner motives and their experiences of their responsibility in developing a caring culture.<p> <p>Research aim - The aim of the study is to get a deeper understanding of middle managers’ motives and their experiences of their responsibility to ...

This article deals with the group-based behavioral, cognitive, and skill-training intervention program Maltti as a special educational support action applied with outdoor adventure education at the primary school level. The need to apply the group-based intervention arose from the special education teachers’ (N=2) desire to reinforce and expand their pedagogical methods in order to improve the ...

Background - Improvement in survival from pancreatic ductal adenocarcinoma (PDAC) has been reported in trial settings but is less explored in unselected cohorts. The aim of this study was to assess trends in provision of treatments and survival in Norway over a 15-year period following the implementation of hepato-pancreato-biliary (HPB) multidisciplinary teams, centralization of surgery, and ...

Visual World eye tracking is a temporally fine-grained method of monitoring attention, making it a popular tool in the study of online sentence processing. Recently, while infrared eye tracking was mostly unavailable, various web-based experiment platforms have rapidly developed webcam eye tracking functionalities, which are now in urgent need of testing and evaluation. We replicated a recent Visual ...

One billion tons of carbon are annually transported to the global ocean, and the fate of this carbon hinges not only on marine processing rates, but also on freshwater processing during downstream transport. Using a cotton-strip assay, we assessed the decomposition of organic matter in marine and freshwater sites and simulated its downstream transport from freshwater to the sea by translocating ...

Lead Rubber Bearings (LRBs) represent one of the most widely employed devices for the seismic protection of structures. However, the effectiveness of the same in the case of curved bridges has not been judged well because of the complexity involved in curved bridges, especially in controlling torsional moments. This study investigates the performance of an LRB-isolated horizontally curved ...

Both climate change and anthropogenic disturbance affect vegetation composition, but it is difficult to separate these drivers of vegetation change from one another. A better understanding of past vegetation dynamics is necessary to disentangle the influence of different forcing factors and assess future vegetation change. Here we present the first multi-proxy palaeoecological study combining ...