Despite advances in myocardial reperfusion therapies, acute myocardial ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number one cause of morbidity and mortality in industrialized societies. Although different therapeutic interventions have been shown beneficial in preclinical settings, an effective cardioprotective or regenerative therapy has yet to be successfully ...

Background: Antiretroviral therapy (ART) has decreased mortality so that increasing numbers of children with HIV are reaching adolescence. However, longstanding HIV infection and/or its treatment in children is associated with noninfectious complications including cardiac disease. We investigated the prevalence, spectrum and risk factors for echocardiographic abnormalities among children established ...

The influence of the ion mass on filament propagation in the scrape-off layer of toroidal magnetised plasmas is analysed for various fusion relevant majority species, like hydrogen isotopes and helium, on the basis of a computational isothermal gyrofluid model for the plasma edge. Heavy hydrogen isotope plasmas show slower outward filament propagation and thus improved confinement properties ...

This paper takes a critical approach to understanding the social and cultural ‘work’ of natural heritage conservation, focussing specifically on ex-situ biodiversity cryopreservation practices. Drawing on ethnographic fieldwork with the Frozen Ark, a UK-based ‘frozen zoo’ aiming to preserve the DNA of endangered animal species, the paper situates the development of nonhuman animal biobanks in ...

Cyanobacteria belonging to the genus Nostoc comprise free-living strains and also facultative plant symbionts. Symbiotic strains can enter into symbiosis with taxonomically diverse range of host plants. Little is known about genomic changes associated with evolutionary transition of Nostoc from free-living to plant symbiont. Here, we compared the genomes derived from 11 symbiotic Nostoc strains ...

Objectives: To examine performance of EUCAST disc diffusion and supplementary MIC methods for detection of Enterobacteriaceae with reduced susceptibility to meropenem using EUCAST screening recommendations.<p> <p>Methods: Sixty-one Nordic laboratories delivered data on EUCAST disc diffusion (n " 61), semi-automated meropenem MIC (n " 23; VITEK2, n " 20 and Phoenix, n " 3) and gradient meropenem ...

In order to optimize recruitment and the overall outcome of educational programmes, it is crucial to understand personal determinants of achievement. While several cognitive abilities and skills individually predict performance in academic and professional settings, it is less clear how personality translates into performance. This study addresses the impact of the Big Five personality trait, ...

Aims: To describe lived experiences of spirituality from the perspective of people who have been subject to inpatient psychiatric care and to interpret these experiences from an understanding of health as dialectical.<p> <p>Methods: After approval from a regional ethical board, eleven participants were recruited from two organisations for people with mental health problems. Participants were ...

Wide-field fluorescence microscopy, while much faster than confocal microscopy, suffers from a lack of optical sectioning and poor axial resolution. 3D structured illumination microscopy (SIM) has been demonstrated to provide optical sectioning and to double the resolution limit both laterally and axially, but even with this the axial resolution is still worse than the lateral resolution of ...