Fenestrations in liver sinusoidal endothelial cells (LSEC) are transcellular nanopores of 50–350 nm diameter that facilitate bidirectional transport of solutes and macromolecules between the bloodstream and the parenchyma of the liver. Liver diseases, ageing, and various substances such as nicotine or ethanol can negatively influence LSECs fenestrations and lead to defenestration. Over the years, ...

Reined into the service of the Cold War confrontation, antifascist ideology overshadowed the narrative about the Holocaust in the communist states of Eastern Europe. This led to the Western notion that in the Soviet Bloc there was a systematic suppression of the memory of the mass murder of European Jews. Going beyond disputing the mistaken opposition between “communist falsification” of history and ...

We present a deep-learning-based algorithm to jointly solve a reconstruction problem and a wavefront set extraction problem in tomographic imaging. The algorithm is based on a recently developed digital wavefront set extractor as well as the well-known microlocal canonical relation for the Radon transform. We use the wavefront set information about x-ray data to improve the reconstruction ...

Models on L3/Ln acquisition differ with respect to how they envisage degree (holistic vs. selective transfer of the L1, L2 or both) and/or timing (initial stages vs. development) of how the influence of source languages unfolds. This study uses EEG/ERPs to examine these models, bringing together two types of bilinguals: heritage speakers (HSs) (Italian-German, n = 15) compared to adult L2 learners ...

Introduction: The treatment of open lower limb fractures represents a major challenge for any trauma surgeon, and this even more so in resource-limited areas. The aim of the study is to describe the intervention, report the treatment plan, and observe the effectiveness of the Norwegian Open Fracture Management System in saving lower limbs in rural settings.<p> <p>Materials and Methods: A ...

More than half of metastatic melanoma patients receiving standard therapy fail to achieve a long-term survival due to primary and/or acquired resistance. Tumor cell ability to switch from epithelial to a more aggressive mesenchymal phenotype, attributed with AXL^high molecular profle in melanoma, has been recently linked to such event, limiting treatment efcacy. In the current study, ...

Whole-genome duplications (WGDs) have long been considered the causal mechanism underlying dramatic increases to morphological complexity due to the neo-functionalization of paralogs generated during these events. Nonetheless, an alternative hypothesis suggests that behind the retention of most paralogs is not neo-functionalization, but instead the degree of the inter-connectivity of the intended ...

Introduction: Although the learning environment influences students’ motivation, learning outcomes, and satisfaction with the study program, less is known about how these factors change as the students’ progress through the study program.<p> <p>Aim: The aim of this study was to examine changes in occupational therapy students’ perceptions of the academic learning environment during their three-year ...

Klebsiella pneumoniae (Kp) can cause hospital- and community acquired infections. Although, Kp is widespread in the environment, very little is known about the genetic diversity and pathogenicity of Kp from the marine environment. The aim of our study was to understand the genetic diversity, resistome and pathogenic potential of 87 Kp isolates from the Norwegian marine environment, using whole-genome ...

This work investigates the pre-collisional (before ca. 650 Ma) history of the Dom Feliciano Belt in southernmost Brazil through geochronological and zircon oxygen isotope study. U–Pb SHRIMP dating of two orthogneiss samples from the Várzea do Capivarita Complex and one metarhyolite sample from the Porongos Complex yielded crystallisation ages of 786 ± 5 Ma, 780 ± 10 Ma and 787 ± 5 Ma, respectively. ...