BACKGROUND: Protein intake is suggested as an important dietary factor in the prevention of frailty, however, the infuence of lifelong intake remains unclear.<p> <p>OBJECTIVES: The present study investigated the relationship between daily protein intake and patterns of protein intake over 21 years and the risk of pre-frailty/frailty. <p>DESIGN: Prospective cohort study. <p>SETTING: The ...

<p><i>Background:</i> There is considerable variation in mortality rates from myocardial infarction (MI) across high-income countries, some of which may be artefactual. Methods: Time trends in mortality rates from ischaemic heart disease (IHD) and MI were analysed for a set of high-income countries from the end of the 1970s. Using individuallevel mortality data from Russia (2005–2017) and Norway ...

Chromosomal abnormalities are one of the main causes of implantation failure following embryo transfer in in vitro fertilization (IVF). Preimplantation genetic testing for aneuploidies (PGT-A) is time-consuming, expensive, and invasive. Non-invasive PGT-A (niPGT-A) is an alternative where secreted embryonic cell-free DNA (cfDNA) in spent culture medium (SCM) is investigated. This study aimed to ...

Herein, we report the synthesis of highly reduced bipyridyl magnesium complexes and the first example of a stable organic magnesium electride supported by quantum mechanical computations and X-ray diffraction. These complexes serve as unconventional homogeneous reductants due to their high solubility, modular redox potentials, and formation of insoluble, noncoordinating byproducts. The applicability ...

The sustainable development and environmental protection of the Arctic ecosystem is on the agenda globally. The Convention of Biological Diversity (CBD) and the UN Sustainable Development Goals call for conserving at least 10 per cent of coastal and marine areas globally. Management tools to achieve this goal include marine protected areas (MPAs) and “other effective area-based conservation ...

This article shows how constructional and usage-based approaches to linguistics can be used to identify strategic input for L2 learners, i.e. input that reflects high frequency patterns in the target language. We suggest a methodology combining constructional and grammatical profiles, and argue that this methodology enables us to identify the most relevant morphological and syntactic constructions, ...

The portfolio of virtual power plants (VPP) is a flexible system for facilitating a wide range of resources with wide geographical coverage. A VPP can be placed at the intersection of electric power and energy systems by adding heat pumps to the portfolio, thereby accelerating the formation of integrated energy systems. VPPs, while virtual, still rely on a physical network for operations. The power ...

With globalization and rapid technological-economic development accelerating the market dynamics, consumers' demand is becoming more volatile and diverse. In this situation, capacity adjustment as an operational strategic decision plays a major role to ensure supply chain responsiveness while maintaining costs at a reasonable norm. This study contributes to the literature by developing computationally ...

A virtual meteor radar system based on the upper-atmosphere extension of the high-resolution ICOsahedral Non-hydrostatic general circulation model is constructed to validate multistatic specular meteor radar (SMR) analyses. The virtual radar system examines the validity of mean winds and gradients estimation techniques used in multistatic SMRs. The study is motivated by unexpected mean values and ...

Background: Mental health disorders among children and youths are common and often have negative consequences for children, youths, and families if unrecognized and untreated. With the goal of early recognition, primary care physicians (PCPs) play a signifcant role in the detection and referral of mental disorders. However, PCPs report several barriers related to confdence, knowledge, and ...