DNA ligases, the enzymes responsible for joining breaks in the phosphodiester backbone of DNA during replication and repair, vary considerably in size and structure. The smallest members of this enzyme class carry out their functions with pared-down protein scaffolds comprising only the core catalytic domains. Here we use sequence similarity network analysis of minimal DNA ligases from all biological ...

The seasonal fisheries in Norway is both a blessing and a curse. The fisheries management have for decades tried to find a way to move some of the seasonal pressure from the traditional season to other parts of the year. This have been done with different levels of success. The duty system is an example of one of the tools that have been tried to secure the supply of fresh fish for the land industry ...

This paper studies how clinical leaders perceive their leadership tasks in the context of virtual interactions. We ask whether distant leadership involves a shift from relationship orientation to more task- and control-oriented leaders in hospital settings. We explore two cases involving 10 clinical leaders in a university hospital in Norway. The study indicates that the leaders were aware that lack ...

Genetisk innblanding fra rømt oppdrettslaks er i dag vurdert av noen som den største trusselen mot ville norske laksestammer. Selv enkelthendelser vil ha en stor risiko for masserømming da en merd kan inneholde opptil 200 000 individ. Samtidig er kjønnsmodning blitt et økende problem særlig knyttet til resirkuleringsanlegg (RAS). Kjønnsmodning bringer med seg en rekke velferdsmessige utfordringer ...

With this thesis, I address gaps in research about how pre-service teachers (PSTs) develop and make use of knowledge for science teaching. In the project I used a qualitative case study approach to investigate seven PSTs’ science teaching, their use of pedagogical content knowledge (PCK) for pedagogical reasoning, and the sources contributing to their development of PCK. I explored how PSTs develop ...

<i>Background</i> - Socioeconomic status and oral health care habits may change throughout adult life. This calls for age-stratified analyses of oral health in the adult population to uncover differences that could be of importance for organizing adequate oral health care services. The aim of the present study was to describe self-reported oral health in different age groups in a general adult ...

<i>Background</i> - In an abdominal symptom study in primary care in six European countries, 511 cases of cancer were recorded prospectively among 61,802 patients 16 years and older in Norway, Denmark, Sweden, Netherlands, Belgium and Scotland. Colorectal cancer is one of the main types of cancer associated with abdominal symptoms; hence, an in-depth subgroup analysis of the 94 colorectal cancers ...

<i>Background/objective</i> - Having a 30-year follow-up of a cohort of women tested for HPV is a unique opportunity to further study long-term risk of CIN3+. The study objective was to compare HPV status at baseline with the risk of CIN3+ in the follow-up period of 30 years.<br><br> <i>Methods</i> - All women (n = 642) referred to the HPV outpatient clinic at the University Hospital of North ...

The adenosine A_2A receptor (A_2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A_2AR-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound ...

<i>Background</i>: Patients with alcohol use disorders (AUD) vary significantly in many clinically important characteristics making them a heterogenous group. AUD patients with comorbid antisocial personality disorder (ASPD) form an important sub-group, and studies indicate that these patients may have poorer treatment outcomes. Therefore, we aimed to investigate the characteristics of AUD inpatients ...