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Development and evaluation of gonadotropin releasing hormone antagonists as SPECT radiotracers
(Doctoral thesis; Doktorgradsavhandling, 2018-05-24)The overall aim of the thesis was to evaluate the potential of gonadotropin releasing hormone receptor (GnRH-R) antagonists as radiotracers for the early detection and understanding of Alzheimer`s disease (AD). The molecular imaging field is a symbiosis between organic chemistry, radiochemistry, in vitro biology, as well as preclinical- and clinical trials, therefore an evaluation should involve all ... -
B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes on B cells for recognition by CD4<sup>+</sup> T cells. It is not known if naive B cells spontaneously display pId:MHCII in vivo or if BCR ligation is required for expression, ... -
Noisy multi-label semi-supervised dimensionality reduction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)Noisy labeled data represent a rich source of information that often are easily accessible and cheap to obtain, but label noise might also have many negative consequences if not accounted for. How to fully utilize noisy labels has been studied extensively within the framework of standard supervised machine learning over a period of several decades. However, very little research has been conducted ... -
On Being Good Gay: 'Covering' and the social structure of being LGBT+
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-03)This essay discusses Cyril Ghosh’s analysis of the notion of ‘gay covering’ as an act of downplaying one’s gayness in the face of public expectations, and its countermove of ‘reversing cover’. I acknowledge, along with Ghosh, that both the demands to ‘cover’ and ‘reverse cover’ are problematic from the perspective of LGBT+ authenticity. I aim to show, however, that such acts of covering, and reversing ... -
Station of the fetal head at complete cervical dilation impacts duration of second stage of labor
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-31)<i>Objective</i> - To examine the association between station of the fetal head at complete cervical dilation and duration of second stage of labor, as well as prolonged second stage of labor, without and with the use of analgesia (EA).<p> <p><i>Study design</i> - We conducted a population-based retrospective cohort study of 3311 women with a singleton pregnancy, gestational age ≥ 37<sup>0</sup> ... -
What is currently the best investigational approach to the patient with sudden-onset severe headache?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-11)<i>Presentation of Case</i> – Ane Skaare Sjulstad, MD, Adult Neurology Resident, Nordland Hospital, Bodø, Norway A 48‐year‐old man with no previous medical history suddenly experienced severe intense retro‐bulbar pain of pulsating character on the right side, and was seen in the emergency department 7 hours later. He was then alert and oriented, but in excruciating pain. There was no neck stiffness ... -
On the Ewald Oseen scattering formulation for light scattering: stability, singularity and parallelization.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-15)In this paper we discuss some of the mathematical and numerical issues that have to be addressed when calculating wave scattering using the Ewald Oseen scattering (EOS) formulation which is newly developed for solving linear and nonlinear scattering problems. The discussion is framed in context of light scattering by objects whose optical response can be of a nonlinear and/or inhomogeneous nature. ... -
Tord Larsen, Emil A. Røyrvik (Red.): Trangen til å telle. Objektivering, måling og standardisering som samfunnspraksis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-12)«Den overordnete ambisjonen med denne boka er å undersøke objektivering, måling og standardisering i vår tid, og vise hvordan disse praksisene utgjør en kulturell logikk som former de fine hoveddimensjonene i sosialt liv: betydning/representasjon, moral, person og ting-forståelse», åpner redaktørene. For antropologer og sosiologer er denne åpningen grei skuring. For leger, sykepleiere, ... -
Young immigrants in Norway: The role of national and ethnic identity in immigrants’ integration
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-08)The present work investigates the endorsement, antecedents, relationships, and consequences of young immigrants’ social identities in Norway. Despite increasing numbers of refugees and immigrants entering Norway in recent years, little is known about the relationship between immigrants’ different social identities and their feeling of integration into Norwegian society. The main goal of the present ... -
Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-19)<i>Background</i> - Observational studies examining the association between oral health and juvenile idiopathic arthritis (JIA) among children and adolescents have reported inconsistent findings. The aims of this systematic review and meta-analysis were to ascertain a potential difference in oral health and oral health-related quality of life (OHRQoL) among children and adolescents with JIA and ... -
The role of adrenoceptors in the central nervous system in male and female rat sexual behavior
(Journal article; Tidsskriftartikkel, 2014-09-10)Three different phases can be distinguished in rats’ sexual cycle, the introductory (precopulatory), the copulatory and the executive (ejaculatory) phases. In this review, a new analysis of existing pharmacological data is made, both in male and female rats, in which the different aspects of sexual behavior are taken into account. An effort is made to distinguish pharmacological effects on sexual ... -
Consistent ice and open water classification combining historical synthetic aperture radar satellite images from ERS-1/2, Envisat ASAR, RADARSAT-2, and Sentinel-1A/B
(Journal article; Tidsskriftartikkel, 2020) -
Surgical Treatment of Degenerative Disk Disease in Three Scandinavian Countries: An International Register Study Based on Three Merged National Spine Registers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-25)<i>Study Design</i>: Observational study of prospectively collected data.<p> <p><i>Objectives</i>: Patients with chronic low back pain resistant to nonoperative treatment often face a poor prognosis for recovery. The aim of the current study was to compare the variation and outcome of surgical treatment of degenerative disc disease in the Scandinavian countries based on The International Consortium ... -
Hjemmedødens lovlighet
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-20)<i>Den døendes rom</i> er kanskje et av de mest private rommene vi kjenner til; hjemme sannsynligvis i enda større grad enn i sykehus eller sykehjem. Også det som skjer innenfor det private territoriet av den døendes rom hjemme, skal være innenfor lovens rammer. En <i>post hoc</i> vurdering av et dødsfalls lovlighet, gjennom en dødsattest, er ikke tilstrekkelig. Hjemmedødens lovlighet må også sikres ... -
Four months vitamin D supplementation to vitamin D insufficient individuals does not improve muscular strength: A randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-16)<i>Main objective</i> - The inconsistent results on the effects of vitamin D on muscle strength reported by intervention trials may partly be explained by inclusion of vitamin D sufficient individuals. The main objective was to study whether vitamin D supplementation will improve muscle strength in men and women with low serum vitamin D status, as measured by 25-hydroxyvitamin D (25(OH)D) at ... -
Caffeine and primary (migraine) headaches-friend or foe?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)<i>Background</i>: The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system. Caffeine influences headaches, the migraine syndrome in particular, but how is unclear.<p> <p><i>Materials and Methods</i>: This is a narrative ... -
Functions of Vocalization in Sociosexual Behaviors in Rats (Rattus norvegicus) in a Seminatural Environment
(Journal article; Tidsskriftartikkel, 2017-01-09)Both male and female rats produce vocalizations in the presence of a potential sexual partner. In this study, we evaluated the role of vocalizations in sociosexual behaviors in an ecologically valid procedure. Three males and 4 females were housed in a seminatural environment. In each group, 1 or 2 males and females were devocalized, and the other subjects were sham operated. Sociosexual interactions ... -
Flexibility in a changing arctic food web: Can rough-legged buzzards cope with changing small rodent communities?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-07)Indirect effects of climate change are often mediated by trophic interactions and consequences for individual species depend on how they are tied into the local food web. Here we show how the response of demographic rates of an arctic bird of prey to fluctuations in small rodent abundance changed when small rodent community composition and dynamics changed, possibly under the effect of climate ... -
Uncertainty and interpretability in convolutional neural networks for semantic segmentation of colorectal polyps
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-20)Colorectal polyps are known to be potential precursors to colorectal cancer, which is one of the leading causes of cancer-related deaths on a global scale. Early detection and prevention of colorectal cancer is primarily enabled through manual screenings, where the intestines of a patient is visually examined. Such a procedure can be challenging and exhausting for the person performing the screening. ... -
Biological stain collection – Absorbing paper is superior to cotton swabs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-14)Biological evidence at crime scenes often contains very small amounts of DNA. Therefore, it is important to use the most effective sampling devices and procedures for stain collection. Currently, cotton swabs moistened with water are widely used, also in our laboratory. However, several studies have shown that other methods may be more efficient.<p> <p>In this study, we compared the DNA sampling ...