Development and evaluation of gonadotropin releasing hormone antagonists as SPECT radiotracers
Permanent lenke
https://hdl.handle.net/10037/17158Dato
2018-05-24Type
Doctoral thesisDoktorgradsavhandling
Forfatter
Fjellaksel, RichardSammendrag
Har del(er)
Paper I: Fjellaksel, R., Boomgaren, M., Sundset, R., Haraldsen, I.H., Hansen, J.H. & Riss, P. (2017). Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor. MedChemComm, 8(10), 1965-1969. Also available at https://doi.org/10.1039/C7MD00320J.
Paper II: Fjellaksel, R., Sundset, R., Riss, P.J. & Hansen, J.H. (2018). Copper-mediated late-stage iodination and 123I-labelling of triazole-benzimidazole bioactives. Synlett, 29(11), 1491-1495. The paper is not available in Munin due to publisher restrictions. Available at https://doi.org/10.1055/s-0036-1591985.
Paper III: Fjellaksel, R., Dugalic, D., Demissie, T.B., Riss, P.J., Hjelstuen, O-K., Sundset, R. & Hansen, J.H. (2018). An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The role of amide group anchimeric assistance. Journal of Physical Organic Chemistry, 31(7), e3835. Also available at https://doi.org/10.1002/poc.3835. Accepted manuscript available in Munin at https://hdl.handle.net/10037/13421.
Paper IV: Fjellaksel, R., Moldes-Anaya, A., Oteiza, A., Martin-Armas, M., Vasskog, T., Riss, P.J. & Sundset, R. In vitro evaluation of two promising bioactive triazole-benzimidazole GnRH Receptor-antagonists as possible candidates for SPECT imaging. (Manuscript). Final version with altered title is available in Munin at https://hdl.handle.net/10037/17184.
Paper V: Fjellaksel, R., Oteiza, A., Martin-Armas, M., Riss, P.J., Hjelstuen, O.K., Kuttner, S. … Sundset, R. First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor based upon the piperazinylbenzimidazole class of compounds. (Manuscript). Final version available in Munin at https://hdl.handle.net/10037/14656.
Forlag
UiT The Arctic University of NorwayUiT Norges arktiske universitet
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