Classification of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients into CIMP (CpG Island Methylator Phenotype) subgroups has the potential to improve current risk stratification. To investigate the biology behind these CIMP subgroups, diagnostic samples from Nordic pediatric T-ALL patients were characterized by genome-wide methylation arrays, followed by targeted exome sequencing, ...

The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ...

<p><i>Background - </i>Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive ...

Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differentiation of BM mesenchymal stromal cells, but they seem to be a heterogeneous population with distinct metabolisms, lipid compositions, secretory properties and ...

In this paper, I develop a new theory of the ingredients of semantic composition for the verb phrase, building on work in Ramchand (2018). I argue that the essential properties of this new approach make possible a new rapprochement between the theoretical analyses of symbolic verbal meaning across the visual and auditory modalities. The innovation of the new theory is that it partitions the verb ...

Teknologi og digitale produkter tar en stadig større del av vår tilkoblede hverdag. Denne oppgaven vil med en materialistisk tilnærming til medieforskning se nærmere på smarthus, hvor hensikten er å vise til andre, ofte underkommuniserte aspekter ved medieteknologi og digitalisering sett fra et miljøperspektiv, som sjeldent adresseres av massemediene. Ved å vise til en undersøkelse som viser til ...

Self-reported pain levels in patients with fibromyalgia may change according to weather conditions. Previous studies suggest that low barometric pressure (BMP) is significantly related to increased pain, but that the contribution of changes in BMP has limited clinical relevance. The present study examined whether BMP influenced variability in perceived stress, and if stress levels moderated or ...

Query-conditioned video summarization requires to (1) find a diverse set of video shots/frames that are representative for the whole video, and that (2) the selected shots/frames are related to a given query. Thus it can be tailored to different user interests leading to a better personalized summary and differs from the generic video summarization which only focuses on video content. Our work targets ...

The thesis What Happened in Northern Norway? is a quantitative analysis of various aspects of the political and demographic development in Northern Norway from 1950 to today. The theories of Ottar Brox and in his seminal work Hva skjer i Nord-Norge? (What Is Happening in Northern Norway?), have influenced regional and national actors in their understanding of the region and their policy development. ...

<p><i>Background - </i>Children of parents with mental illness (COPMI) are a high-risk group. There is a strong association between parents’ psychiatric disorders and the incidence of psychopathology in their children. These children need to be identified and supported by mental health workers early, and hence, clinical practice in adult mental health services needs to change from a focus on individual ...