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Safety and efficiency of a new generic package labelling: A before and after study in a simulated setting
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-20)Background: Medication errors are frequent and may cause harm to patients and increase healthcare expenses. <p> Aim: To explore whether a new labelling influences time and errors when preparing medications in accordance with medication charts in an experimental setting. <p> Method: We carried out an uncontrolled before and after study with 3 months inbetween experiments. Phase I used original ... -
Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-17)We here report the preparation of a new 2,6,8-trisubstituted bicyclic tripeptidomimetic scaffold through TFA-mediated cyclization of a linear precursor containing three side chains. The introduction of a triphenylmethyl-protected thiol into carboxylic acid containing building blocks through sulfa Michael additions onto α,β-unsaturated hexafluoroisopropyl esters is described. The stereoselectivity ... -
Parent participation in alcohol prevention: Evaluation of an alcohol prevention programme
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-25)Aim: <br>The main purpose of this study was to evaluate the effectiveness of the parental part of the Norwegian Unge & Rus (Youth and Alcohol) programme. The intervention was aimed at changing parents’ rules and attitudes towards adolescent alcohol use, and their ability to talk with their adolescents about alcohol, as well as improving parents’ relationships with and knowledge about their ... -
Probability revision in general practice: the cases of occult blood in stool in patients with indigestion, and daily smoking in patients who cough
(Journal article; Tidsskriftartikkel; Peer reviewed, 1990)Prior calculation of the sex- and age-distributed positive predictive value (PPV) of a symptom in relation to a disease forms the basis for probability revision based on new information about signals observed during the medical encounter: a symptom, a sign, a piece of information based on the medical history, a laboratory test. Probability revision requires estimates of sensitivity and specificity ... -
Linking brain networks and behavioral variability to different types of mind-wandering
(Others; Andre, 2017-07-13) -
Molecular analyses reveal high cryptic diversity of trematodes in a sub-Arctic lake
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-14)To identify trematode diversity and life-cycles in the sub-Arctic Lake Takvatn, Norway, we characterised 120 trematode isolates from mollusc first intermediate hosts, metacercariae from second intermediate host fishes and invertebrates, and adults from fish and invertebrate definitive hosts, using molecular techniques. Phylogenies based on nuclear and/or mtDNA revealed high species richness (24 ... -
Trust versus perceived quality in scholarly publishing: A personality-attitude-intention approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-01)Digital academic journals serve as the main dissemination method for peer-reviewed research articles. These journals can be divided into two main categories: open access (OA) and non– open access (non-OA) journals. OA literature is defined by Suber as “digital, online, free of charge, and free of most copyright and licensing restrictions.” The reasons why no-cost OA adoption is slow-going ... -
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-23)<b>Background:</b> Many patients with limited disease small cell lung cancer (LD SCLC) suffer from comorbidity. Not all patients with comorbidity are offered standard treatment, though there is little evidence for such a policy. The aim of this study was to investigate whether patients with comorbidity had inferior outcomes in a LD SCLC cohort. <br><b>Material and methods:</b> We analyzed patients ... -
Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-18)Background: Metastatic colorectal cancer (CRC) is associated with highly variable clinical outcome and response to therapy. The recently identified consensus molecular subtypes (CMS1-4) have prognostic and therapeutic implications in primary CRC, but whether these subtypes are valid for metastatic disease is unclear. We performed multi-level analyses of resectable CRC liver metastases (CLM) to ... -
Going skin deep: a direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model
(Journal article; Tidsskriftartikkel, 2017-09-12)Phospholipid-based nanocarriers are attractive drug carriers for improved local skin therapy. In the present study, the recently developed isolated perfused human skin flap (IPHSF) model was used to directly compare the skin penetration enhancing potential of the three commonly used nanocarriers, namely conventional liposomes (CLs), deformable liposomes (DLs) and solid lipid nanoparticles (SLNs). ... -
Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-21)Chronic wounds represent a significant health problem worldwide. There is a need for advanced- and cost-efficient wound healing products able to increase patient comfort and reduce the healing time. The aim of this study was to develop a sprayable hydrogel dressing with beta-glucan (βG) as the active ingredient, targeting future application in the treatment of both chronic and burn wounds. The βG ... -
Molecular transfer to Atlantic salmon ovulated eggs using liposomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-15)The delivery of exogenous biomolecules into teleost eggs is currently mostly relying on the manual microinjection methods, which, due to their high costs and low throughput, are not economically feasible for large-scale aquaculture applications. The main objective of this study was to develop a convenient, simple immersion delivery model for unfertilized Atlantic salmon (Salmo salar L.) eggs using ... -
How robust are in situ observations for validating satellite-derived albedo over the dark zone of the Greenland Ice Sheet?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-17)Calibration and validation of satellite‐derived ice sheet albedo data require high‐quality, in situ measurements commonly acquired by up and down facing pyranometers mounted on automated weather stations (AWS). However, direct comparison between ground and satellite‐derived albedo can only be justified when the measured surface is homogeneous at the length‐scale of both satellite pixel and in situ ... -
Metabolic reprogramming supports the invasive phenotype in malignant melanoma
(Journal article; Tidsskriftartikkel, 2015)Invasiveness is a hallmark of aggressive cancer like malignant melanoma, and factors involved in acquisition or maintenance of an invasive phenotype are attractive targets for therapy. We investigated melanoma phenotype modulation induced by the metastasis-promoting microenvironmental protein S100A4, focusing on the relationship between enhanced cellular motility, dedifferentiation and metabolic ... -
Sea-ice dynamics in an Arctic coastal polynya during the past 6500 years
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-23)The production of high-salinity brines during sea-ice freezing in circum-arctic coastal polynyas is thought to be part of northern deep water formation as it supplies additional dense waters to the Atlantic meridional overturning circulation system. To better predict the effect of possible future summer ice-free conditions in the Arctic Ocean on global climate, it is important to improve our ... -
Structural insight into a CE15 esterase from the marine bacterial metagenome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-08)The family 15 carbohydrate esterase (CE15) MZ0003, which derives from a marine Arctic metagenome, has a broader substrate scope than other members of this family. Here we report the crystal structure of MZ0003, which reveals that residues comprising the catalytic triad differ from previously-characterized fungal homologs, and resolves three large loop regions that are unique to this bacterial ... -
Svøpt i myra - Synspunkter på Skjoldehamnfunnets etniske og kulturelle tilknytning
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017)In 1936 an extraordinary find of a clothed skeleton wrapped in a blanket and covered with birch bark appeared in a bog at Skjoldehamn on Andøya Island. The wrapped body was laid on a reindeer pelt, which in turn was placed on sticks of birch. The grave dates to the 11th century, probably the later half. Compared with relevant Norse, Sámi, and Christian graves and burial customs, the Skjoldehamn grave ... -
Tidal Energy Loss, Internal Tide Radiation, and Local Dissipation for Two-Layer Tidal Flow over a Sill
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-14)A simple analytical model for tidal energy loss at fjord sills and its partitioning into local dissipation and radiated internal tides is presented. The analytical model builds on a two-layer assumption with quasi-steady nonlinear flow over the sill and wave radiation in the far field. When the interface is situated above sill level, upstream- and downstream-propagating internal waves are generated ... -
Diagenetic alteration of benthic foraminifera from a methane seep site on Vestnesa Ridge (NW Svalbard)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-08)Anomalously low δ<sup>13</sup>C values in foraminiferal calcite tests are due to diagenetic alteration in methane seep sites. Our study applies diagenetically altered fossil benthic foraminiferal tests as geochemical tracers in reconstructing natural past methane seepage episodes at Vestnesa Ridge offshore NW Svalbard. We combine examinations of the test wall microstructure, mineralogical and stable ... -
Production, consumption, and migration of methane in accretionary prism of southwestern Taiwan
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-15)To systematically quantify the production, consumption, and migration of methane, 210 sediment cores were collected from offshore southwestern Taiwan and analyzed for their gas and aqueous geochemistry. These data, combined with published results, were used to calculate the diffusive methane fluxes across different geochemical transitions and to develop scenarios of mass balance and constrain deep ...