Background - The biological relevance and accuracy of gene expression data depend on the adequacy of data normalization. This is both due to its role in resolving and accounting for technical variation and errors, and its defining role in shaping the viewpoint of biological interpretations. Still, the choice of the normalization method is often not explicitly motivated although this choice may be ...

Introduction: In pediatric physical therapy, there is an ongoing debate about the use of therapeutic handling and its potential effects on motor learning. In this study, we build on enactive theoretical perspectives to explore the role of therapeutic handling in connection to children's sensory-motor play, engagement, and performance during a single physical therapy session.<p> <p>Material and ...

In Spanish clitic-doubling constructions, the clitic should agree in number with its coreferential doubled noun phrase. However, the present corpus analysis with data from 21 Spanish varieties reveals that, under certain structural configurations, number agreement is not always realized on the third-person dative clitic. In fact, the data shows that non-agreement appears to be the norm when the ...

Meteor observations provide information about Solar System constituents and their influx onto Earth, their interaction processes in the atmosphere, as well as the neutral dynamics of the upper atmosphere. This study presents optical, radar, and infrasound measurements of a daytime fireball that occurred on 4 December 2020 at 13:30 UTC over Northeast Sweden. The fireball was recorded with two video ...

Excess mortality has been used to measure the impact of COVID-19 over time and across countries. But what baseline should be chosen? We propose two novel approaches: an alternative retrospective baseline derived from the lowest weekly death rates achieved in previous years and a within-year baseline based on the average of the 13 lowest weekly death rates within the same year. These baselines express ...

<b><p>Background:</b> The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment leads to around 60% overall 5-year survival, yet with impaired postsurgical quality of life. Observational studies indicate that curatively intended chemoradiotherapy, ...

This study examined potential sources of grammatical gender variability in heritage speakers (HSs) of Italian with a focus on morphological markedness. Fifty-four adult Italian HSs living in Germany and 40 homeland Italian speakers completed an online Self-Paced Reading Task and an offline Grammaticality Judgment Task. Both tasks involved sentences with grammatical and ungrammatical noun-adjective ...

Introduction: Victims of accidental hypothermia in hypothermic cardiac arrest (HCA) may survive with favorable neurologic outcome if early and continuous prehospital cardiopulmonary resuscitation (CPR) is started and continued during evacuation and transport. The efficacy of cerebral autoregulation during hypothermic CPR is largely unknown and is aim of the present experiment.<p> <p>Methods: ...

Background: Shufeng Jiedu (SFJD) capsules can be used as adjunctive treatment for patients with community-acquired pneumonia, but the effectiveness and safety of SFJD are not clear. This review aims to evaluate the effectiveness and safety of SFJD based on randomized controlled trials (RCTs).<p> <p>Methods: A systematic review was conducted by searching PubMed, Embase, Scopus, Web of Science, ...

Coordinating complex crisis responses generally requires comprehensive skills. When operating in the High Arctic, extreme environments make this task even more challenging. Training for these situations is thus of utmost importance, but such training requires extensive resources for full-scale exercises. Simulation is an alternative that can yield an effective learning process and learning outcomes. ...