Childhood obesity has reached epidemic proportions globally and represents a major threat to children’s health. Data on effectiveness of treatment programs for childhood obesity beyond one year is limited and there is little high-quality evidence to recommend one treatment over another. The objective of the clinical trial The Finnmark Activity School was to compare a new multidisciplinary approach ...

<p><i>Background and aims - </i>Much research has been conducted on age-related changes in cognitive function, but psychomotor abilities, such as manual dexterity, have been less studied. A better understanding is needed of which movement components account for the general slowing of performance and how central factors, such as cognitive decline, contribute to slowing. The aims of this thesis were ...

Inspired by precautionary and participatory approaches to risk governance of novel technologies, this thesis concerns how to acknowledge and handle scientific uncertainties in policy-relevant science. I have addressed this topic by mapping perspectives on uncertainties, benefits and concerns related to the use of modern biotechnology in aquaculture, among scientists, policy advisors and other impacted ...

Background: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal antibodies that target fetal platelets during pregnancy. It can occur when fetal platelets express a paternally-inherited antigen that is not shared by the mother. Maternal antibodies that cause FNAIT are directed against human platelet antigens (HPAs) on fetal platelets, and the resulting fetal/ neonatal ...

<p>There is a consistent finding that the higher the socioeconomic position (SEP), the better the health. The choice of SEP indicator is crucial in explaining these socioeconomic inequalities. However, a poorly motivated use of SEP indicators prevails in the literature on social health inequalities, hampering the transparency and comparability across studies. Its primary aim is to explore different ...

Selective autophagy is responsible for the lysosomal degradation of damaged and surplus cytoplasmic components, including misfolded proteins and dysfunctional organelles. Selective autophagy is required for protein and organelle quality control basally and upon stress. For the autophagic process to be precise, selective autophagy receptors (SARs) like SQSTM1/p62 are required. Autophagic substrates ...

<p><i>Aim -</i> To assess the adherence to medication therapy for secondary prevention and achievement of treatment goals in persons with coronary heart disease (CHD) in a general population. <p><i>Methods -</i> This project used data from the seventh wave of the Tromsø Study, alone and linked with data from the Norwegian Prescription database (NorPD). Participants self-reporting CHD were included ...

The main aim of this dissertation was threefold. First, to establish norms for a psychometric inventory used to assess behavior problems. The project presents the first Norwegian standardization of an assessment tool specifically designed to measure childhood conduct problems. Norwegian norms for the Eyberg Child Behavior Inventory (ECBI; Robinson, Eyberg, & Ross, 1980) based on data obtained ...

Merkel cell carcinoma (MCC) is a rare, highly aggressive neuroendocrine skin cancer. More than 80% of MCC have Merkel cell polyomavirus (MCPyV) clonally integrated into the human genome (VP-MCC) while the remaining 20% are virus negative (VN-MCC) but linked with chronic exposure to UV sunlight. MCC is particularly associated with immune suppression with 8-48 folds increase in incidence in immunosuppressive ...

The two major forms of Inflammatory bowel disease (IBD), Ulcerative Colitis (UC) and Crohn’s Disease (CD), are characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host-microbe interaction. This overwhelming complexity makes IBD ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient ...