Blar i tittel Doktorgradsavhandlinger (Helsefak)
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Exploring the pangenome of Staphylococcus haemolyticus. Colonisation, hospital adaption, pathogenicity and novel species identification
(Doctoral thesis; Doktorgradsavhandling, 2020-04-03)Staphylococcus haemolyticus is a ubiquitous bacterium recognised as a significant cause of nosocomial infections. Today it represents one of the most clinically relevant staphylococcal species, hallmarked by its extreme genome plasticity and multiresistant phenotype. Despite its relevance, little is known about its virulence repertoire or how it causes disease. The main objective of this PhD thesis ... -
Exploring the roles of TRIM27 and TRIM32 in autophagy
(Doctoral thesis; Doktorgradsavhandling, 2021-05-21)<p>Tripartite motif family proteins (TRIMs) are a wide family of E3 ligases involved in the control of several cellular processes such as intracellular signaling, innate immunity, transcription, cell cycle regulation and carcinogenesis. In recent years, some members of this family have been found to have a role in autophagy. <p>The central theme of this thesis is the role of two TRIM proteins in ... -
Expression and activity of NADPH oxidases (NOX) and the ROS-mediated effects on γ-Glutamyltransferase (GGT) expression in cancer cells
(Doctoral thesis; Doktorgradsavhandling, 2010-12-10)Cancer cells with the ability to metastasize have also an ability to adapt and survive in new surroundings. This is connected to their ability to alter the balance between and the level of oxidants and antioxidants within the cell. To understand how cancer cells do this, a panel of cancer cells were examined with respect to genes that can affect the oxidant production. These cells had been isolated ... -
Expression and functional properties of selected miRNAs in human cancer tissue and cancer cell lines
(Doctoral thesis; Doktorgradsavhandling, 2019-03-01)MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) involved in the regulation of gene expression, and they are often seen dysregulated in cancer. For this reason, it is of great scientific interest to study these ncRNAs to better understand their distribution in human tissues and their mode of function. Based on a comprehensive miRNA microarray from 108 breast cancers in the Norwegian Woman and ... -
Extended-spectrum β-lactamases and carbapenemases in clinical isolates of Enterobacteriaceae in Norway. Aspects of detection and epidemiology.
(Doctoral thesis; Doktorgradsavhandling, 2015-04-16) -
Factors affecting doctors' decision making
(Doctoral thesis; Doktorgradsavhandling, 1996) -
Factors behind high cardiovascular disease mortality in Northwest Russia. The Arkhangelsk study.
(Doctoral thesis; Doktorgradsavhandling, 2011-06-10)Background Cardiovascular disease (CVD) mortality in Russia is among the highest in the world. CVD mortality rate among Russian middle-aged (30-59) men and women is more than ten times higher than in Norway. Comparative studies however show that abnormally high levels of the conventional (atherosclerotic) cardiovascular risk factors such as serum cholesterol, obesity, diabetes and hypertension are ... -
Factors that determine children’s participation in child welfare decision making.
(Doctoral thesis; Doktorgradsavhandling, 2015-03-05) -
Falsifiable Network Models. A Network-based Approach to Predict Treatment Efficacy in Ulcerative Colitis
(Doctoral thesis; Doktorgradsavhandling, 2022-12-09)This work is focused on understanding the treatment efficacy of patients with ulcerative colitis (UC) using a network-based approach. UC is one of two forms of inflammatory bowel disease (IBD) along with Crohn’s disease. UC is a debilitating condition characterized by chronic inflammation and ulceration of the colon and rectum. UC symptoms occur gradually rather than abruptly, and the degree of ... -
Family and community involvement in Indigenous social work. A comparative study
(Doctoral thesis; Doktorgradsavhandling, 2018-12-07)This thesis investigates the relevance of family and community involvement for culturally adequate social work in Indigenous communities. The study is qualitative and comparative. I compare social work within Indigenous communities in Norway and Montana with the aim of adding to the available knowledge regarding culturally adequate social work in these communities. The thesis consists of three ... -
Family care strategies in an unpredictable ICU environment. ICU nurses’ and physicians’ interprofessional and individual strategies for critically ill ICU patients’ families – a qualitative study
(Doctoral thesis; Doktorgradsavhandling, 2022-12-13)<p><i>Background:</i> Critical illness not only disrupts the patient’s life, but also the lives of close family members. The care provided by ICU nurses and physicians can reduce the family members’ burden and improve the patient's outcome. Previous research shows that although ICU families generally report high satisfaction, there are several barriers to family care and areas for improvement. Family ... -
Family focus in mental health and social services for adults: Supporting minor children of parents in challenging life situations
(Doctoral thesis; Doktorgradsavhandling, 2023-11-30)Parental mental illness, parents’ loss of ability to work and family poverty affect children and put them at risk for adverse life outcomes. Support for and attendance to minor children and parenting in adult mental health and social services should therefore be an incorporated practice. The main aim of this thesis was to investigate the extent and quality of a family focus in these adult services. ... -
Family members' experiences of decision-making processes in the context of withholding or withdrawing treatment in the ICU. A qualitative interview study
(Doctoral thesis; Doktorgradsavhandling, 2013-01-24)This thesis is based on the decision-making process involved in treatment termination in intensive care. ICU patients often have impaired consciousness and may therefore lack capacity to consent. In such cases, the health care personnel have the decision-making authority, but where a serious intervention for the patient is involved, information should if possible be obtained from the patient’s ... -
Fetal cardiac output and its distribution to the placenta and brain at 11-20 weeks of gestation
(Doctoral thesis; Doktorgradsavhandling, 2009-09-11)Objective: To study some aspects of fetal heart structure and function using ultrasonography at 11-20 weeks of gestation with an emphasis on the distribution of cardiac output to the placenta and upper body including brain. <br> Methods: In a cross-sectional study of unselected pregnant population, the structure of the fetal heart was studied using transvaginal ultrasonography and feasibility ... -
A five-year prospective follow-up of longstanding eating disorders : influence from personality disorders and child sexual abuse
(Doctoral thesis; Doktorgradsavhandling, 2010-05-05)Follow-up studies have shown that 20-30% of patients with eating disorders develop longstanding symptoms seriously impairing their daily life. There are very few studies on the course of these patients. <br>This dissertation consists of three papers on patients admitted to a specialized inpatient treatment program at the Modum Bad psychiatric hospital. The participants were assessed upon admission, ... -
FKBP8 and the autophagy-inducing Class-III PI3K Complex Roles of LIR dependent interactions
(Doctoral thesis; Doktorgradsavhandling, 2017-09-22)Autophagy (Greek meaning “self eating”) is a renovation process in cells. Dysfunctional autophagy plays a major role in human diseases including cancer, inflammatory and neurodegenerative diseases. Misfolded or aggregated proteins, damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as intracellular pathogens are degraded by autophagy. During the process, the ... -
Football training specificity - Training individualization within the collective periodization
(Doctoral thesis; Doktorgradsavhandling, 2020-02-04)Within the literature, different playing positions present different external load profiles in match-play and are associated with the individual variation in activity profiles. In contrast to detailed information regarding matches, few studies have focused on the training practices in football. Therefore, the aim of this thesis is to assess the levels of specificity that different playing-positions ... -
Fractional exhaled nitric oxide and its relation to exercise, asthma and allergic rhinoconjunctivitis in a subarctic childhood population. A study of asthma and allergy among schoolchildren in Nordland County.
(Doctoral thesis; Doktorgradsavhandling, 2014-11-07)Astma og allergisk øye- og nesekatarr (rhinokonjunktivitt, AR) er de vanligste kroniske sykdommene blant barn i den vestlige verden. I de siste tiårene har prevalensen (forekomsten) av sykdommene økt betydelig, men i enkelte Europeiske land rapporteres det om en utflating i prevalensen av astma. I klinisk praksis brukes laboratorietester til å understøtte diagnosene astma og AR. Analyser av biologiske ... -
Frail homebound elderly: basic nursing challenges of home care : a comparative study across 11 sites in Europe
(Doctoral thesis; Doktorgradsavhandling, 2009-02-12)The overall purpose of this thesis is to describe, analyse, and compare characteristics of the basic needs (nutrition and elimination) and clinical features of the elderly receiving home care. Data are derived from the Aged in Home Care (AD-HOC) project, a cross-sectional population-based study at 11 urban sites in Europe (2001/2003), using Resident Assessment Instrument for Home Care. During data ... -
From policy to practice: Implementation of changes in law to support and protect children of ill parents
(Doctoral thesis; Doktorgradsavhandling, 2019-11-22)<p>Children of parents with serious forms of illness have shown to be vulnerable to developing a wide variety of psychosocial problems themselves. The research literature strongly indicates that preventive interventions may protect against well-documented transgenerational risk factors and strengthen the children’s resilience by promoting protective factors. Despite this knowledge, there is a gap ...