Blar i tittel Doktorgradsavhandlinger (Helsefak)
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Fetal cardiac output and its distribution to the placenta and brain at 11-20 weeks of gestation
(Doctoral thesis; Doktorgradsavhandling, 2009-09-11)Objective: To study some aspects of fetal heart structure and function using ultrasonography at 11-20 weeks of gestation with an emphasis on the distribution of cardiac output to the placenta and upper body including brain. <br> Methods: In a cross-sectional study of unselected pregnant population, the structure of the fetal heart was studied using transvaginal ultrasonography and feasibility ... -
A five-year prospective follow-up of longstanding eating disorders : influence from personality disorders and child sexual abuse
(Doctoral thesis; Doktorgradsavhandling, 2010-05-05)Follow-up studies have shown that 20-30% of patients with eating disorders develop longstanding symptoms seriously impairing their daily life. There are very few studies on the course of these patients. <br>This dissertation consists of three papers on patients admitted to a specialized inpatient treatment program at the Modum Bad psychiatric hospital. The participants were assessed upon admission, ... -
FKBP8 and the autophagy-inducing Class-III PI3K Complex Roles of LIR dependent interactions
(Doctoral thesis; Doktorgradsavhandling, 2017-09-22)Autophagy (Greek meaning “self eating”) is a renovation process in cells. Dysfunctional autophagy plays a major role in human diseases including cancer, inflammatory and neurodegenerative diseases. Misfolded or aggregated proteins, damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as intracellular pathogens are degraded by autophagy. During the process, the ... -
Football training specificity - Training individualization within the collective periodization
(Doctoral thesis; Doktorgradsavhandling, 2020-02-04)Within the literature, different playing positions present different external load profiles in match-play and are associated with the individual variation in activity profiles. In contrast to detailed information regarding matches, few studies have focused on the training practices in football. Therefore, the aim of this thesis is to assess the levels of specificity that different playing-positions ... -
Fractional exhaled nitric oxide and its relation to exercise, asthma and allergic rhinoconjunctivitis in a subarctic childhood population. A study of asthma and allergy among schoolchildren in Nordland County.
(Doctoral thesis; Doktorgradsavhandling, 2014-11-07)Astma og allergisk øye- og nesekatarr (rhinokonjunktivitt, AR) er de vanligste kroniske sykdommene blant barn i den vestlige verden. I de siste tiårene har prevalensen (forekomsten) av sykdommene økt betydelig, men i enkelte Europeiske land rapporteres det om en utflating i prevalensen av astma. I klinisk praksis brukes laboratorietester til å understøtte diagnosene astma og AR. Analyser av biologiske ... -
Frail homebound elderly: basic nursing challenges of home care : a comparative study across 11 sites in Europe
(Doctoral thesis; Doktorgradsavhandling, 2009-02-12)The overall purpose of this thesis is to describe, analyse, and compare characteristics of the basic needs (nutrition and elimination) and clinical features of the elderly receiving home care. Data are derived from the Aged in Home Care (AD-HOC) project, a cross-sectional population-based study at 11 urban sites in Europe (2001/2003), using Resident Assessment Instrument for Home Care. During data ... -
From policy to practice: Implementation of changes in law to support and protect children of ill parents
(Doctoral thesis; Doktorgradsavhandling, 2019-11-22)<p>Children of parents with serious forms of illness have shown to be vulnerable to developing a wide variety of psychosocial problems themselves. The research literature strongly indicates that preventive interventions may protect against well-documented transgenerational risk factors and strengthen the children’s resilience by promoting protective factors. Despite this knowledge, there is a gap ... -
Functional ultrasound of the anal canal. The effect of pregnancy and childbirth
(Doctoral thesis; Doktorgradsavhandling, 2011-06-22)This thesis is concerned with functional three-dimensional ultrasound of the anal canal. Comparing acquisitions assessed with endoanal- and transvaginal transducers, the transvaginal transducer turned out to be as good as the endovaginal transducer. In addition, the curvatures, position and dimensions of the undisturbed anatomical structures in the anal canal, including the anal mucosa, could be ... -
Gene expression in blood and cancer risk factors – Investigating associations of blood gene expression with Smoking, BMI, and Menopause in the Norwegian Women and Cancer (NOWAC) postgenome cohort
(Doctoral thesis; Doktorgradsavhandling, 2023-10-24)<p><i>Background:</i> Linking blood gene expression and common cancer risk factors represents an intriguing approach for gaining valuable biological insights. Smoking and obesity are important modifiable cancer risk factors. Menopause is also an important factor due to its impact on cancer risk. Still, there is limited or no research evaluating associations of blood gene expression profiles with ... -
Gene expression profile of normal and compromised placentas
(Doctoral thesis; Doktorgradsavhandling, 2009-06-26)<b>Objective</b> <br>Placenta has an important function of sustaining life in utero. Role of placental gene expression in the physiology of parturition and pathogenesis of pregnancy disorders are poorly understood. The aims of this thesis were to: <br>1. Investigate the effect of labor on global gene expression profile of normal placentas <br>2. Compare placental gene expression profile of ... -
General practitioner hospitals : use and usefulness : a study from Finnmark County in North Norway.
(Doctoral thesis; Doktorgradsavhandling, 1998) -
General Practitioners’ Decisions to Refer Patients to Secondary Care – Referral Rates, Reasons for Referral and Expected Medical Benefit of the Referrals
(Doctoral thesis; Doktorgradsavhandling, 2015-04-09)Summary Background The referral rates of general practitioners (GPs) are an important determinant of secondary care utilisation. The considerable variation in these rates between GPs cannot be explained by patient morbidity alone. Other factors, like health care organisation, GP characteristics and patient preference play an important role, but the extent of their mutual contributions is not ... -
A genetic spectrum approach to affective and schizophrenic disorders : a twin- and family study
(Doctoral thesis; Doktorgradsavhandling, 2009-09-15)Over 300 eneggete- og toeggete tvillingpar rekruttert fra sykehusarkiv, og deres 1.grads slektninger (foreldre og søsken), ble intervjuet personlig og diagnostisert i henhold til moderne diagnostiske systemer (DSM-III-R) både med hensyn til symptomforstyrrelser (Akse I), og personlighetsforstyrrelser (Akse II). De ble også intervjuet angående forhold knyttet til tvillingenes fødsel og oppvekst. ... -
Genetic Susceptibility, Lifestyle, Ovarian Hormones, and Mammographic Density – key factors in breast cancer development. The Norwegian Energy Balance and Breast Cancer Aspects-I Study.
(Doctoral thesis; Doktorgradsavhandling, 2013-02-28)Breast cancer is the most frequent cancer among women worldwide. Over the last century, the prevalence of overnutrition, overweight and obesity has increased, age at menarche has dropped and age at birth of first child has risen among women in Western countries. These trends may be linked to exposure to ovarian hormones that, in turn, may affect a woman’s lifetime risk of getting breast cancer. The ... -
Genital Chlamydia trachomatis infections among adolescents in a high-incidence area in Norway: genotypes, prevalence, early sexual behaviour and testing patterns – a cross-sectional study The Finnmark High School Study (FHSS)
(Doctoral thesis; Doktorgradsavhandling, 2013-12-06)Chlamydia trachomatis is the most commonly reported curable sexually transmitted infection in Western high-income countries and can cause severe female reproductive tract morbidity. Despite extensive control efforts, chlamydia rates have increased in most countries since the mid-1990s. Young persons and especially adolescent girls have the highest infection rates. In general, girls are tested far ... -
A genome-wide study of gene expression regulation in the Gram-negative fish pathogen Aliivibrio salmonicida
(Doctoral thesis; Doktorgradsavhandling, 2011-10-04)Regulation of gene expression is essential for all bacteria to function and survive. The expression of genes into proteins is dependent on a number of steps, each of which can be subjected to regulation. In the literature much emphasis has typically been placed on transcriptional regulation, but during recent years gene regulation at the post-transcriptional level has also gained much attention. One ... -
Geographic and socioeconomic variation in the utilisation of specialist health care services in Norway – Three selected health care services
(Doctoral thesis; Doktorgradsavhandling, 2022-06-21)<p>The overall theme of this thesis is geographic and socioeconomic variation in the use of specialist health care services. Three different health care services were studied. Complete population data on individual level with high level of quality from nationwide registries (i.e., The Norwegian Patient Registry, The Cancer Registry of Norway and Statistics Norway) were used in the analysis. <p>The ... -
Glucose metabolism, genetic factors, vitamin D binding protein and directly measured free 25-hydroxyvitamin D -Results from a randomized controlled trial with high-dose vitamin D supplementation in subjects with prediabetes
(Doctoral thesis; Doktorgradsavhandling, 2016-04-21)Tidligere studier har vist en sammenheng mellom vitamin D-nivåer og type 2 diabetes, men om vitamin D kan brukes for å forebygge type 2 diabetes, har ikke vært kjent. 511 personene ble inkludert i studien og jevnt fordelt til å motta enten ukentlig høy-dose vitamin D-tilskudd eller narremedisin (placebo). Etter ett år var det ingen effekt av vitamin D-tilskudd på utviklingen av type 2 diabetes ... -
Group-based and individualized physiotherapy for persons with multiple sclerosis - A qualitative observational and interview study
(Doctoral thesis; Doktorgradsavhandling, 2019-11-11)Physiotherapy is a complex professional practice, particularly in the care for persons with multiple sclerosis (MS). Group-based organization of interventions is a common treatment approach in MS rehabilitation, regardless of limited knowledge on the nature of essential elements of such professional practices. This dissertation presents and discusses how actions and interactions affect opportunities ... -
Growing an information infrastructure for healthcare based on the development of large-scale Electronic Patient Records
(Doctoral thesis; Doktorgradsavhandling, 2018-04-04)This thesis provides empirical insights about socio-technical interdependencies affecting the making and scaling of an Information Infrastructure (II) for healthcare based on the development of large-scale Electronic Patient Records. The Ph.D. study is an interpretive case study, where the empirical data has been collected from 2012 to 2017. In most developed countries, the pressures from politicians ...