All of clinical work also has a moral dimension since the purpose of health care is to help patients. The aim of this project is to understand how doctors deal with these moral dimensions of clinical work. The field of bioethics has largely emerged as a philosophically founded discipline, without taking into account how doctors already handle moral values as a tacit or implicit part of their clinical ...

Patogenesen ved inflammatorisk tarmsykdom (IBD) er fortsatt ikke fullstendig klarlagt. Mye forskning har blitt gjort de siste tjue årene for å kartlegge immunresponsen ved ulcerøs kolitt og Crohns sykdom. Man antar at et samspill mellom genetiske faktorer, miljøfaktorer og bakterier ligger bak utviklingen av sykdommen. Kartleggingen av immunresponsen i tarmen har vært grunnlaget for utviklingen av ...

Pain is common in otherwise healthy youth and is often associated with psychosocial problems. However, there is limited knowledge of how pain-troubled adolescents fare from adolescence into young adulthood. To examine this, the Norwegian Arctic Adolescent Health Study, a 10th grade school-based survey (15–16-year-olds) conducted in North Norway, in 2003–2005, was linked to the Norwegian Patient ...

Neuroblastoma is the most common extra-cranial solid tumor in childhood. Tumors with amplification of the MYCN proto-oncogene are characterized by aggressive biology and poor survival of the patients. To improve future treatment options, it is of fundamental interest to understand MYCN’s role in tumorigenesis and determine factors regulating MYCN expression. In this thesis focuses on the interactions ...

Skin diseases are among the top 5 most leading diseases causing non-fatal health burden worldwide and strategies to assure more effective treatments are urgently needed. Dermal therapy is very attractive due to the direct administration of the drug at the diseased skin site thus minimizing systemic side effects associated with the oral and parenteral routes. However, the great variety within the ...

”Hvor mye?”, ”Hvor ofte?” og ”Hvor lenge?” er sentrale spørsmål i studier av legemidler. For å finne en optimal behandling trenger man kunnskap om et legemiddels opptak, fordeling i kroppen, og nedbryting. Øie sitt prosjekt viser at leveren spiller en nøkkelrolle i nedbrytningen av to sentrale substanser som hemmer blodlevring (antikoagulantia), heparin og tissue factor pathway inhibitor (TFPI). ...

Persistent Organic Pollutants (POPs) and toxic elements are released into the environment and are carried to the Arctic area via the atmosphere, oceanic currents and rivers. They have the ability to accumulate in nature and bioconcentrate in the human food chain. The primary exposure route for these contaminants is through diet, and thus circulating levels in pregnant women can give an indication ...

Positron emission tomography is a non-invasive imaging modality allowing visualization and quantification of a wide variety of physiological and biochemical processes or of a specific lowdensity protein target. Some examples are blood flow, glucose consumption, fatty acid metabolism or detection and quantification of cell surface receptors in particular tissues. Within the spectrum of available ...

<p><i>Introduction</i> Hypertension and kidney damage are reciprocally related. Current blood and urine tests cannot reliably detect early kidney damage from hypertension, hindering timely prevention. A biomarker that captures kidney damage due to hypertension at an early stage might improve risk stratification and treatment. The primary objective of this project was to investigate how biomarkers ...

The association between gait and cognition in aging has been widely studied with the help of dual-task paradigms consisting of walking while simultaneously performing a cognitive task. However, previous dual-task research has lacked consistency in methods. In this doctoral work, we introduced a novel dual-task paradigm including Dichotic Listening (DL) performed concomitantly with walking overground. ...