This thesis aims to: i) explore the importance of preference-weighting in health state utility (HSU) instruments and ii) examine the contribution of policy-relevant factors to subjective well-being (SWB). The analyses herein are based on an international sample of individuals aged 18 and above, and this thesis comprises three papers. Paper 1 examined the relative importance of preference-weighting ...

In order for the HIV virus to take over and destroy human immune cells, which results in AIDS, the virus first has to enter the cells. This takes place by interactions between viral proteins and specific receptors on the surface of our cells. One of these receptors is CXCR4, and it has been shown that chemical compounds that bind to and block the CXCR4 receptor, so-called CXCR4 antagonists, are able ...

Dát čielggadeapmi geahččala čájehit ovttasdoaimma báikkálaš veahkehanárbevieruid ja almmolaš psykalaš dearvvašvuođabálvalusaid gaskka Finnmárkkus ja Davvi-Romssas, ja jearrá galggašii go dán guovtti vuogi gaskka leat eanet ovttasbargu. Danne geahčadit dás dárkileappot mat báikkálaš veahkehanárbevierut leat dáid sámi ja máŋggakultuvrralaš guovlluin, man ollu pasieanttat geavahit dáid, ja háliidit ...

Akuttmedisinske pasienter har ofte krevende og komplekse medisinske behov som lokale, tverrfaglige team må bidra til å møte. Akuttmedisinforskriften pålegger trening i samhandling for tjenestene utenfor sykehus. Vi ønsket derfor å utforske og forbedre lokal team trening. I Alta har lokalt helsepersonell systematisk arrangert slike treninger hver måned siden 2007, forankret i egen kompetanse og egen ...

The aim of this thesis was to explore the effect of transcranial direct current stimulation (tDCS) as a symptom modifying treatment for Alzheimer’s disease. tDCS is a non-invasive brain stimulation technique where weak direct current is delivered to the scalp, causing neuromodulation as it reaches the cortex. Even though promising, the results of clinicals studies have been mixed. This thesis explored ...

In this thesis, it was investigated whether mothers` EMSs would predict maternal-fetal bonding quality during pregnancy (paper 1), whether attachment style would be associated with mother-infant bonding quality after birth (paper 2), and if these relations were mediated by symptoms of depression (paper 1) and parenting stress (paper 2). EMSs and anxious and avoidant attachment styles may be thought ...

Avhandlingen er basert på komplette nasjonale tall på behandlingsresultat fra pasienter som ble behandlet med kurativ radiokjemoterapi for anal cancer fra 2000-07. Langtidsoverlevere ble tilbudt deltagelse i en oppfølgingsstudie for kartlegging av uønskede seneffekter. Helserelatert livskvalitet (HRQOL), nevrotoksisitet og fekal inkontinens ble kartlagt ved bruk av spørreskjema og telefonintervju ...

Obstructive sleep apnea (OSA) is a respiratory sleep-disorder characterized by repeated breathing cessations due to pharyngeal soft tissue collapse, leading to several medical disorders and possibly premature death. Two commonly used treatment alternatives for OSA are continuous positive airway pressure (CPAP) and mandibular advancement splints (MAS). The overall aim of this randomized clinical trial ...

This study focuses on the triggering mechanisms leading to development of the neurodegenerative disorder Fragile X-associated tremor/ataxia syndrome (FXTAS). FXTAS affects carriers of a “premutation” in the Fragile X Mental Retardation 1 (FMR1) gene on the X chromosome. A premutation in this context, means the presence of 55-200 CGG repeats in the 5’untranslated region of the gene. Unaffected ...

<p>TRIM proteins are ubiquitin E3 ligases known to be involved in a number of different processes in the cells, such as intracellular signaling, transcription, autophagy, innate immunity, cell cycle progression and DNA repair. Mutations and dysregulation of TRIM proteins are implicated in many diseases, and a number of TRIMs are described as both tumor suppressors and oncogenes. Furthermore, several ...