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Browsing Artikler, rapporter og annet (farmasi) by Issue Date

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The role of pharmacoepidemiological studies in the market withdrawal of carisoprodol (Somadril®) in Europe.

Skurtveit, Svetlana; Bramness, Jørgen; Buajordet, Ingebjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)

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URI: http://hdl.handle.net/10037/3182

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Veitrafikkulykker knyttet til forskrivning av legemidler : En registerbasert kohortstudie

Skurtveit, Svetlana; Engeland, Anders; Bramness, Jørgen G.; Mørland, Jørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)

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URI: http://hdl.handle.net/10037/3152

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Repeated dispensing of codeine is associated with high consumption of benzodiazepines

Skurtveit, Svetlana; Bachs, Liliana Casulleras; Bramness, Jørgen G.; Engeland, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)

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URI: http://hdl.handle.net/10037/3151

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article.pdf (415.7Kb)

Characterization of the Ion Exchange Reaction Between Propranolol-H+ or K+ with Amberlite IRP 69 Resin by Both, Isothermal Titration Calorimetry and (Flame) Photometric Equilibrium Analysis

Zeiss, Daniel Horst; Wagner, Marita; Bauer-Brandl, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

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URI: http://hdl.handle.net/10037/3183

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article.pdf (313.4Kb)
A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib

Ernst, Thomas; Gruber, Franz; Pelz-Ackermann, Oliver; Mikkola, ingvild; Maier, J; Pfirrmann, M; Muller, MC; Porkka, Kimmo; Niederwieser, D; Hochhaus, A; Lange, T (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

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URI: http://hdl.handle.net/10037/3181

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article.pdf (221.4Kb)

In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate

Okeke, Malachy Ifeanyi; Tryland, Morten; Nilssen, Øivind; Moens, Ugo; Traavik, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 12-May-2009)

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Abstract:

Background: Poxvirus-vectored vaccines against infectious diseases and cancer are currently under development. We hypothesized that the extensive use of poxvirus-vectored vaccine in future might result in co-infection and recombination between the vaccine virus and naturally occurring poxviruses, resulting in hybrid viruses with unpredictable characteristics. Previously, we confirmed that co-infecting in vitro a Modified vaccinia virus Ankara (MVA) strain engineered to express influenza virus haemagglutinin (HA) and nucleoprotein (NP) genes with a naturally occurring cowpox virus (CPXV-NOH1) resulted in recombinant progeny viruses (H Hansen, MI Okeke, Ø Nilssen, T Traavik, Vaccine 23: 499–506, 2004). In this study we analyzed the biological properties of parental and progeny hybrid viruses.
Results: Five CPXV/MVA progeny viruses were isolated based on plaque phenotype and the expression of influenza virus HA protein. Progeny hybrid viruses displayed in vitro cell line tropism of CPXV-NOH1, but not that of MVA. The HA transgene or its expression was lost on serial passage of transgenic viruses and the speed at which HA expression was lost varied with cell lines. The HA transgene in the progeny viruses or its expression was stable in African Green Monkey derived Vero cells but became unstable in rat derived IEC-6 cells. Hybrid viruses lacking the HA transgene have higher levels of virus multiplication in mammalian cell lines and produced more enveloped virions than the transgene positive progenitor virus strain. Analysis of the subcellular localization of the transgenic HA protein showed that neither virus strain nor cell line have effect on the subcellular targets of the HA protein. The influenza virus HA protein was targeted to enveloped virions, plasma membrane, Golgi apparatus and cytoplasmic vesicles.
Conclusion: Our results suggest that homologous recombination between poxvirus-vectored vaccine and naturally circulating poxviruses, genetic instability of the transgene, accumulation of non-transgene expressing vectors or hybrid virus progenies, as well as cell line/type specific selection against the transgene are potential complications that may result if poxvirus vectored vaccines are extensively used in animals and man.

URI:

http://hdl.handle.net/10037/2191

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article.pdf (949.6Kb)

Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappa B

Grotterød, Ida; Mælandsmo, Gunhild; Pedersen, Kjetil Boye (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

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URI: http://hdl.handle.net/10037/3096

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article.pdf (2.250Mb)

Uptake and organ distribution of feed introduced plasmid DNA in growing or pregnant rats

Grønsberg, Idun; Nordgård, Lise; Fenton, Kristin Andreassen; Hegge, Beate; Nielsen, Kaare Magne; Bardocz, Susan; Pusztai, Arpad; Traavik, Ingemar Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)

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URI: http://hdl.handle.net/10037/3838

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article.pdf (602.1Kb)

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Abstract:	Benthic marine invertebrates collected from sub-Arctic regions of northern Norway, were found to be a promising source of novel bioactive compounds against human and fish pathogenic bacteria and fungi. Lyophilized material from seven species of ascidians, six sponges and one soft alcyonid coral were extracted with 60% acidified acetonitrile (ACN). After separation into an ACN-rich phase (ACN extract) and an aqueous phase, and subsequent solid phase extraction of the aqueous phase, fractions differing in polarity were obtained and screened for antibacterial and antifungal activities, along with the more lipophilic ACN-extracts. Antimicrobial activity was determined against two Gram-negative, two Gram-positive bacteria, and two strains of fungi. Notably, all the invertebrate species in the study showed activity against all four strains of bacteria and the two strains of fungi. In general, the aqueous fractions displayed highest antimicrobial activity, and the most potent extracts were obtained from the colonial ascidian Synoicum pulmonaria which displayed activity against bacteria and fungi at a concentration of 0.02 mg/ml; the lowest concentration tested.
Description:	This is the accepted manuscript version of the article. Reprinted with permission. Published version is available at http://dx.doi.org/10.1016/j.jip.2008.06.009 The published version of this article is part of Margey Tasesse's doctoral thesis, which is available at http://hdl.handle.net/10037/2702
URI:	http://hdl.handle.net/10037/2728

Abstract:	Novel sonosensitive doxorubicin-containing liposomes comprising dioleoylphosphatidylethanolamine (DOPE) as the main lipid constituent were developed and characterized in terms of ultrasound-mediated drug release in vitro. The liposome formulation showed high sonosensitivity; where approximately 95% doxorubicin was released from liposomes after 6 min of 40 kHz US exposure in buffered sucrose solution. This represented a 30% increase in release extent in absolute terms compared to liposomes comprising the saturated lipid analogue distearoylphosphatidylethanolamine (DSPE), and a 9-fold improvement in release extent when compared to standard pegylated liposomal doxorubicin, respectively. Ultrasound release experiments in the presence of serum showed a significantly reduction in sonosensitivity of DSPE-based liposomes, whilst the release properties of DOPE-based liposomes were essentially maintained. Dynamic light scattering measurements and cryo-transmission electron microscopy of DOPE-based liposomes after ultrasound treatment indicated liposome disruption and formation of various lipid structures, corroborating the high release extent. The results point to the potential of DOPE-based liposomes as a new class of drug carriers for ultrasound-mediated drug delivery.
Description:	This article is part of Tove Julie Evjen's doctoral thesis. Available in Munin at http://hdl.handle.net/10037/3373
URI:	http://hdl.handle.net/10037/4485

Abstract:	Ultrasound sensitive (sonosensitive liposomes) are drug delivery systems designed for releasing their drug load upon exposure to ultrasound (US). Inclusion of dioleoylphosphatidylethanolamine (DOPE) in liposome membranes was previously shown to induce sonosensitivity. For efficient US mediated drug delivery to solid tumours, a long blood circulation time of the liposomal drug providing high tumour uptake is required. In this study, blood pharmacokinetics of DOPE-based liposomal doxorubicin (DXR) were evaluated in mice. A markedly faster blood clearance of DXR was observed for DOPE-rich liposomes compared to Caelyx! (standard liposomal DXR). Subsequently, liposome membrane composition was altered to improve drug retention in the bloodstream, while maintaining sonosensitivity. Formulations with reduced blood clearance of DXR were obtained by reducing the content of DOPE from 62 to 32 or 25 mol%. These formulations showed long blood circulation time, as approximately 20% of the administered DXR dose was present in the bloodstream 24 h after intravenous injection. The reduction in liposomal DOPE content did not significantly reduce US mediated DXR release in vitro, indicating that DOPE is a potent modulator to sonosensitivity. The novel liposome formulations, containing moderate amounts of DOPE, displayed similar blood pharmacokinetic profiles as standard liposomal DXR, but a markedly improved sonosensitivity.
Description:	This article is part of Tove Julie Evjen's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/3373
URI:	http://hdl.handle.net/10037/3756

Browsing Artikler, rapporter og annet (farmasi) by Issue Date

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Browsing Artikler, rapporter og annet (farmasi) by Issue Date

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