| Abstract: | The topic covered in this thesis is medical temperature measurement of subcutaneous parts of human tissue with use of microwave radiometry. Radiometry is a completely non-invasive, non-toxic and relatively inexpensive sensing modality. The radiometric technique is based on the measurement of electromagnetic noise power emitted by lossy materials. The method has explicit low investment costs and low technological complexity, but relatively low spatial resolution. Still the method can be useful for some dedicated medical applications. Fundamental radiometric theory and dielectrical properties of biological tissues are derived. The process to realize a miniaturized radiometer is going from active antenna configuration to a complete miniaturized radiometer and finally to a modular radiometer, that is used \textsl{in-vivo} on humans. Different radiometers were designed, simulated, built and tested on realistic human phantoms. \textit{In vivo} experiments were also conducted to verify the prototype radiometer and to test the ability to be used in tailored medical diagnostics. The primary application covered is temperature gradient measurement during microwave hyperthermia and in pediatric vesicouretaral reflux (VUR) detection. Hyperthermia is a therapeutic technique in which cancerous tissue is heated to 40-45$^\circ$C, inducing vascular and cellular changes that improve the therapeutic effectiveness when used in conjunction with chemotherapy or radiation therapy. VUR is abnormal flow of urine from the bladder back to the upper urinary tract. Another application where this radiometer can be of great interest is in breast cancer diagnostic. Breast cancer is a type of cancer that forms in tissues of the breast; usually in the ducts and lobules and can occur in both men and woman. We present results from radiometric measurement on human phantoms during a hyperthermia heating sequence. Experimental evidence shows that radiometry can be used for temperature quality assurance of the heated volume in depth. In VUR detection, the first step is to heat the bladder prior to detection of the reflux. We present results from measurements \textsl{in-vivo} with a water filled balloon in the human mouth, that mimics pediatric bladder heating. Results show that the radiometer can be used as the first step in the novel VUR detection. Radiometry antennas are one of the most critical components in a radiometer system. An elliptical printed circuit board antenna is designed and matched to the human body. Further, an antenna with suction, with use of negative pressure to mount the antenna onto the human body for improved radiometric performance, was also proposed and built. The simple and elegant solution for the coupling of the antenna with use of negative pressure, documents improved performance in estimating the true temperature as well as exhibiting smaller fluctuation in the radiometric signal. |
| Description: | Papers 1,3,4 and 5 of this thesis are not available in Munin: 1. Ø. Klemetsen, Y. Birkelund, and S. K. Jacobsen: 'Design of medical radiometer front-end for improved performance', Progress In Electromagnetics Research B (2011) Vol. 27, 289–306. Available at http://www.jpier.org/PIERB/pier.php?paper=10101204 3. Øystein Klemetsen and Svein Jacobsen: 'Improved Radiometric Performance Attained by an Elliptical Microwave Antenna With Suction', IEEE transactions on biomedical engineering (2012)59(1):263-271. Available at http://dx.doi.org/10.1109/TBME.2011.2172441 4. Yngve Birkelund, Øystein Klemetsen, Svein K. Jacobsen, Kavitha Arunachalam, Paolo Maccarini, and Paul R. Stauffer: 'Vesicoureteral Reflux in children : a phantom study of microwave heating and radiometric thermometry of pediatric bladder', IEEE transactions on biomedical engineering (2011)58(11):3269-3278. Available at http://dx.doi.org/10.1109/TBME.2011.2167148 5. Svein Jacobsen and Øystein Klemetsen: 'Improved detectability in medical microwave radio-thermometers as obtained by active antennas', IEEE transactions on biomedical engineering (2008)55(12):2778-2785. Available at http://dx.doi.org/10.1109/TBME.2008.2002156 |
| URI: | http://hdl.handle.net/10037/3818 |
| Abstract: | Rockslides have a high socioeconomic and environmental importance in many coun- tries. Norway is particularly susceptible to large rockslides due to its many fjords and steep mountains. One of the most dangerous hazards related to rock slope failures are tsunamis that can lead to large loss of life. It is therefore very important to systemati- cally identify potential unstable rock slopes. In this thesis, we consider the use of satellite remote sensing interferometric syn- thetic aperture radar (InSAR) for detecting surface displacement in rural areas of Norway. The main focus of the work has been on developing small baseline (SB) InSAR time series methods for mapping and monitoring of rockslides in Norway. The first part of the thesis is a basic review of the satellite SAR imaging instrument, with a focus on the InSAR methodology. Different satellite sensors and their limitations is discussed. The introduction chapters have been written with the nonspecialist in mind. In the second part of the thesis, we present a discussion about particular InSAR processing challenges in Norway, as well as preliminary results from two ongoing research projects, with the aim of demonstrating the possibilities that emerges by using new high-resolution SAR sensors, as well as the potential to perform continuous surface displacement monitoring using radar corner reflectors. The last chapters of the thesis demonstrate that InSAR is a powerful tool that can be used to identify the relative magnitude and spatial pattern of active rockslide sites on both a regional and individual rockslide site scale. |
| Description: | The papers of the thesis are not available in Munin due to publishers' restrictions. 1. Tom R. Lauknes, Howard A. Zebker and Yngvar Larsen: 'InSAR Deformation Time Series Using an L1-Norm Small-Baseline Approach', IEEE Transactions on Geoscience and Remote Sensing Volume 2011, vol. 49, issue 1, 536-546. Available at http://dx.doi.org/10.1109/TGRS.2010.2051951 2. Tom R. Lauknes: 'InSAR Tropospheric Stratification Delays: Correction Using a Small Baseline Approach' (submitted version). Published version, IEEE Geoscience and Remote Sensing Letters vol 8 number 6 (2011), is available at http://dx.doi.org/10.1109/LGRS.2011.2156381 3. T.R. Lauknes , A. Piyush Shanker, J.F. Dehls, H.A. Zebker, I.H.C. Henderson and Y. Larsen: 'Detailed rockslide mapping in northern Norway with small baseline and persistent scatterer interferometric SAR time series methods', Remote Science of Environment 2010, vol. 114, issue 9, 2097-2109. Available at http://dx.doi.org/10.1016/j.rse.2010.04.015 4. I.H.C. Henderson, T.R. Lauknes, P.T. Osmundsen, J. Dehls, Y. Larsen and T.F. Redfield: 'A structural, geomorphological and InSAR study of an active rock slope failure development', In: Jaboyedoff, M. (ed.): 'Slope Tectonics', Geological Society, London, Special Publications, 351, 185–199, available at http://dx.doi.org/10.1144/SP351.10 © The Geological Society of London 2011 5. P.T. Osmundsen, I. Henderson, T.R. Lauknes, Y. Larsen, T.F. Redfi eld and J. Dehls: 'Active normal fault control on landscape and rock-slope failure in northern Norway', Geology, February 2009; v. 37; no. 2; p. 135–138. Available at http://dx.doi.org/10.1130/G25208A.1 |
| URI: | http://hdl.handle.net/10037/2970 |
| Description: | The papers in Chapter 8, Appendix A are not avaiable in Munin: 8.1.Yong Liu, Otto J. Anshus, Phuong H. Ha, Tore Larsen and John Markus Bjørndalen: "MultiStream - A Cross-platform Display Sharing System Using Multiple Video Streams", Distributed Computing Systems Workshops, ICDCS’08. Available at http://dx.doi.org/10.1109/ICDCS.Workshops.2008.16 8.2. Yong Liu and Otto J. Anshus: "Improving the Performance of VNC for High-Resolution Display Walls", CTS 2009, Maryland, USA, May 18, 2009. Available at http://dx.doi.org/10.1109/CTS.2009.5067504 8.3. Yong Liu, John Markus Bjørndalen and Otto J. Anshus: "Using Multi-Threading and Server Update Pushing to Improve the Performance of VNC for a Wall-sized Tiled Display Wall", InfoScale 2009: The 4th International ICST Conference on Scalable Information Systems, 2009. Available at http://dx.doi.org/10.1007/978-3-642-10485-5_22 |
| URI: | http://hdl.handle.net/10037/2959 |
| Abstract: | The motivation behind this thesis has been to study particle precipitation from the Sun into the Earth’s upper atmosphere and its effects on selected ionospheric phenomena. Particles from the solar wind can enter the Earth's magnetosphere through magnetic merging, either at the sub-solar point, or at higher latitudes, depending on the configuration of the interplanetary magnetic field. This interaction can be studied from the ground at Svalbard, due to its fortuitous location beneath the magnetospheric cusp region on the dayside, and its location inside the polar cap during night-time. It has been studied how these precipitating particles act on the aurora and ion-acoustic waves in the ionized part of the atmosphere. The studies have been conducted using various methods, including extracting data from databases, running different experiments and building new instrumentation. The latter was a radiation detector for measuring Bremsstrahlung X-rays. The main instrument used for this study has been the EISCAT (European Incoherent SCATtering) radar located at Svalbard, together with an assortment of other ground based instruments such as photometers, riometers and magnetometers. In addition, particle instruments onboard satellites have been used as well as an X-ray instrument mounted on a balloon launched from Longyearbyen. Primarily, it is the effect of particle precipitation on large ion-acoustic waves that has been studied. These waves can be observed by advanced radar facilities, both from Svalbard and Tromsø (EISCAT) in the form of spectra known as natural enhanced ion acoustic lines (NEIALs). It has been found that the most energetic particle precipitation causes ion-acoustic waves which mainly propagate downward, while the less energetic part of the particle precipitation is related to ion-acoustic waves which propagate upward. In this project, large ion-acoustic waves have been discovered during night-time at very high latitudes where they were not expected to occur. Previously, these phenomena have only been observed during daytime at Svalbard. Furthermore, in this work, the infrared atomic oxygen emission line (844.6 nm) has been introduced as a new possible method to detect NEIALs in optical data. Particle precipitation sometimes cause flickering aurora, hence intensity variation and the apparent motion of flickering spots in the aurora have been studied. Finally, precipitating particles typically consists of electrons and ions, and in this study, an example is given on of how the merging of the Earth’s and Sun’s magnetic fields guide the precipitation. |
| Description: | Papers 2 and 4 are not available in Munin: 2. T. Grydeland, B. Gustavsson, L. Baddeley, J. Lunde, and E. M. Blixt: 'Conditional integration of Incoherent Scattering in relation to flickering aurora', Journal of Geophysical Research (2008), vol.113, A08305, 8pp. Available at http://dx.doi.org/doi:10.1029/2008JA013039 4. B. Gustavsson, J. Lunde, and E. M. Blixt: 'Optical observations of flickering aurora and its spatio-temporal characteristics', Journal of Geophysical Research (2008), vol.113, A12317, 8pp. Available at http://dx.doi.org/10.1029/2008JA013515 |
| URI: | http://hdl.handle.net/10037/4221 |
| Abstract: | Optical waveguides are used to confine propagating light. In a dielectric waveguide, a small part of the propagating light travels along and just outside the waveguide surface. This evanescent field can interact with objects on the waveguide surface. Two effects of this light-matter interaction are presented, optical forces and Raman scattering. Optical forces are caused by changes in the momentum of radiation. The forces are exerted on objects interacting with a propagating field. The magnitude of the force is dependent on the difference in permittivity and permeability between the object and the surrounding medium. The forces can be used to trap and control micro- and nanoparticles. In Raman scattering, the scattered field exchanges energy with the scatterer. The amount of energy that is lost or gained depends on the molecular structure of the scatterer. By collecting the spectra of the scattered light, the molecules in the scatterer can be analyzed and characterized. Two numerical studies have been performed to simulate optical forces on a range of micrometer-sized objects trapped and propelled on a waveguide. A numerical model of a hollow glass sphere provides new insights on how the optical force depends on the glass thickness. A numerical model of a red blood cell studies the force dependence on cell shape and refractive index. A model of a real-sized cell is made. Two experimental studies have used Raman spectroscopy to characterize and analyze objects subject to optical forces. One study looks at the viability of using Raman scattering to characterize objects trapped on waveguides. It was found that characterization with Raman spectroscopy is viable with the use of an external, focused light source, while excitation using the evanescent field is difficult. A second study investigates a new technique for proliferation measurements of non-adherent cells. A combined optical trapping–Raman spectroscopy setup is used to show that a Raman probe can be used to measure proliferation of actively replicating cells, even in a sample were the cell growth is slow or negative. The presented studies were performed to investigate the potential of combining characterization with optical trapping on waveguides. This could be of use in an optical lab-on-a-chip for cells. |
| URI: | http://hdl.handle.net/10037/5151 |
| Description: | The papers of this thesis are not available in Munin: 1. Myhre, P.I., Corfu, F. & Andresen, A.: 'Caledonian anatexis of Grenvillian crust: a U/Pb study of Albert I Land, NW Svalbard', Norwegian Journal of Geology (2008) Vol. 89, pp. 173-191. Available at http://www.geologi.no/data/f/0/20/00/8_2401_0/NJG309_P._I._Myhre_et_al_screen.pdf 2. Per Inge Myhre, Fernando Corfu, Steffen Bergh: 'Palaeoproterozoic (2.0–1.95 Ga) pre-orogenic supracrustal sequences in the West Troms Basement Complex, North Norway', Precambrian Research (2011) vol. 186, pp.89–100. Available at http://dx.doi.org/10.1016/j.precamres.2011.01.003 3. Per Inge Myhre, Fernando Corfu and Steffen Bergh: 'U-Pb geochronology along a Neoarchaean geotransect in the West Troms Basement Complex, North Norway' (manuscript). 4. Bergh, S.G., Kullerud, K., Armitage, P.E.B., Zwaan, K.B., Corfu, F., Ravna, E.J.K. & Myhre, P.I.: 'Neoarchaean to Svecofennian tectono-magmatic evolution of the West Troms Basement Complex, North Norway', Norwegian Journal of Geology (2010) Vol. 90, pp 21-48. Available at http://www.geologi.no/data/f/0/20/23/8_2401_0/NJG_1_2010_Bergh_sc.pdf |
| URI: | http://hdl.handle.net/10037/3660 |
| Abstract: | For the mass transfer case (the absorption of moisture-water into concrete), the water content in concrete has a significant impact on its mechanical properties. Moisture transport in porous media, for example, plays an important role in the degradation of building materials such as mortars and concrete. LWE ignores the complex pore structure and network, typically found in cement materials. Many earlier research works has shown clearly that complex pores structure of concrete, strongly impedes the water penetration. Following this line, we believe also that the changing of pore structure may impose a strong effect on the water capillary suction. |
| Description: | Paper 3 of the thesis is not available in Munin due to publishers' restrioction: 3. Hung Thanh Nguyen, Frank Melandsø and Stefan Jacobsen: 'Time dependent durface heat transfer in light weight aggregate cement based materials', Engineering, 2010, 2, 307-317. Available at http://dx.doi.org/10.4236/eng.2010.25040 |
| URI: | http://hdl.handle.net/10037/3443 |
| Abstract: | The work summarized in this thesis has its basis in technology to support human collaboration. I have investigated how large, high-resolution display (LaHiRD) technology, implemented using display wall technology (large, tiled displays implemented as one coherent display surface) could support clinical work. Hence, I have worked with the topic of technological support for human collaboration (or –interaction) in a medical context. This thesis is three-tiered; one layer is related to how a certain novel technology, (very-) large-high-resolution displays may be of clinical use. The second layer relates to specific cognitive effects users of the novel technology may experience. The third layer relates to a novel analysis framework for sosiotechnical (STS) systems (LaHiRD technology creates STSs in use). Summarized, I found LaHiRD technology’s most prominent and interesting features to be the possibility for arbitrary sized displays and vast pixel-counts achievable. This affords a wide-range of uses, but is particularly interesting for group work situations and may enable a more ‘natural’ and embodied ‘arena’ for reasoning. In collaboration with the Radiology department at UNN an implementation of a prototype radiology interface for a Display Wall was made. A crude interface was designed, which was presented in a demo for the UNN radiologists and a couple of other invited specialists. This demo was videotaped and transcribed and the main results were extracted from these data, and others from the notes and interviews made in the design process for the radiology interface. It was found that yes: the clinicians were quite positive towards the clinical potential for technology, such as the Display Wall. Focus in future studies should be information design with more diverse and currently (visually-) unavailable information – and specific information to support the workflow and specific cognitive processes of group work-settings. Regarding the Second layer, contemporary research was at this time focusing on cognitive effects of display size. For instance: how does it affect our experience of the documents displayed that size increases? Does increasing size help our problem solving? Does increasing size help some groups of users more than others? Which tasks are affected by display size in this regard? Such questions have been posed and answered during the last decade and some of the results were intriguing for my work as well. In collaboration with Department of Psychology at UiT we found that we could try and figure out how tasks similar to those performed at a Radiology department is affected by display size. We designed an experiment to test how display size affects a spatial ability called ‘mental rotation’ (MR). Mental rotation is the task of deciding whether two images of arm-like structures, made from cubes attached face to face, are the same. This task is intuitively similar to the kind of work performed at a radiology department. ‘Objects’ (organs, body-parts, blood vessels, etc.) are viewed from different angles (‘coronal’, ‘sagittal’, ‘transverse’) and ‘healthy objects’ are compared to ‘pathological’. We designed two separate experiments. Both were a mixed design with Display Size and Angle (-of rotation between the MR stimuli objects) were within-subjects factors, while Sex was between-subjects factor. Our first study included 40 subjects of 4 groups where we alternated the two groups of males/females of which display condition they were tested first in. We presented half of the participants in the first experiment with a hypothesis stating that large displays should yield better performance, while the other half were presented with the opposite hypothesis – that smaller displays provides better performance. We found that females were indeed faster than males on the large display (but no difference in accuracy). However, the group of females who had been presented prior to the experiment with the hypothesis that large displays are better were performing significantly faster than all other three groups (females ‘believing’ that small displays are superior and both male groups). In order to strengthen this finding, or reject the hypothesis that the display size was affecting female performance (and that ‘belief’ alone was making females better), we designed a new experiment where we left out any explicit information regarding hypothesis. In the second experiment we also recruited more subjects in order to provide more evidence to our finding. We had 36 males and 32 females perform the same task as in the first experiment and we improved the research design. We used a high-speed camera to compute – and ‘control’ – a network delay in stimulus onset for the large display condition. This made within-subjects comparison in performance on small contra large display more reliable. Again we found that females significantly outperformed males in the large display condition. On average, females were about 20% faster than males in the large display condition. However, females did not perform faster on the Display Wall than on the laptop display. What we found, rather, was that males and females performed similar in the smaller laptop display condition and that the Display Wall condition had a significant detrimental effect on male performance, actually deteriorating their small-display performance by 20%. In summary, we have found that visually enlarging objects may have a detrimental effect on work-tasks that involve mental rotation of three-dimensional objects – a task that resembles the work typically performed in Radiology departments. This effect was observed with objects about twice the size of typical object sizes used in the traditional Shepard-Metzler MR task (comparing two objects at a time). As for the Third layer of this thesis, this involved establishing a document lens – processing (and ‘extracting) ‘document theory’ and developing a model – in collaboration with Documentation Studies at UiT, for systems analysis. The document model which I have assembled is comprised of 7 components: agent, means, modes, configuration, connection, construction and results (Olsen et al., 2012). This model encompasses all issues that have been a part of this thesis; the agents (Radiologists/other healthcare personnel) the technical infrastructure (means and modes; the ‘what’ and the ‘how’), the perceptual qualities of the Display Wall (how ‘larger’ may not always better – i.e. the perceptual Configuration of the document) and the social affordances (Connection) and finally – the Result (resulting document): the radiology interface (although only a crude prototype). The document model, I found, is a holistic and broad model that arguably encompass traditional ‘physical objects’ (a printed book; a contract) and all novel, digital documents. I have tried to explicate- and place this model, concept and the theory behind in relation to other ‘sociotechnical methodology’. In the Document Analysis (DA), we use the framework of traditional document analysis to try and analyse, or predict novel documents. Analysing present documents (already created), or historical documents may create a basis, or casting mould for experimental analysis. A document analysis, as presented in my work, may well have value as a communicating artefact, or Boundary Object in the requirements phase of systems development and –design, especially for sociotechnical systems where non-technical (non-functional) requirements are important. As for how to utilize DA in this context, the novel document model provides a framework and a template for document analysis. |
| Description: | Papers 1,2,3,4,5,6,8,9 & 10 of this thesis are not available in Munin: 1. Niels Windfeld Lund, Bernt Ivar Olsen, Otto Anshus, Tore Larsen, John Markus Bjørndalen and Gunnar Hartvigsen: '"Watch the Document on the Wall!” An Analytical Model for Health Care Documents on Large Displays', in Goos, G., Hartmanis, J. & Leeuwen, J. V. (Eds.) Lecture Notes in Computer Science, proceedings from Web Information Systems Engineering – WISE 2007 Workshops. (2007), vol. 4832/2007:395-406. Available at http://dl.acm.org/citation.cfm?id=1781545&CFID=254149216&CFTOKEN=96596662 2. Bernt Ivar Olsen, Sanjaya Babu Dhakal, Odd Petter Eldevik, Per Hasvold and Gunnar Hartvigsen: 'A large, high resolution tiled display for medical use : experiences from prototyping of a radiology scenario', Studies in health technology and informatics (2008), vol.136:535-40. Available at http://ebooks.iospress.nl/publication/11635 3. Bernt Ivar Olsen, Bruno Laeng, Kari-Ann Kristiansen and Gunnar Hartvigsen: 'Spatial tasks on a large, high-resolution tiled display : females mentally rotate large objects faster than men', In Engineering Psychology and Cognitive Ergonomics (2009), D. Harris, Springer Berlin / Heidelberg. 5639: 233-242. Available at http://link.springer.com/content/pdf/10.1007%2F978-3-642-02728-4_25 4. Bernt Ivar Olsen, Bruno Laeng, Kari-Ann Kristiansen and Gunnar Hartvigsen: 'Spatial tasks on a large, high-resolution, tiled display : a male inferiority in performance with a mental rotation task', In 'Engineering Psychology and Cognitive Ergonomics' D. Harris, Springer Berlin / Heidelberg (2011), vol. 6781:63-71. Available at http://link.springer.com/content/pdf/10.1007%2F978-3-642-21741-8_8 5. Bernt Ivar Olsen, Bruno Laeng, Kari-Ann Kristiansen and Gunnar Hartvigsen: 'Remember to Control for the (un)expected while Designing Controlled Experiments in HCI: The case of Sex Differences in the Spatial Ability of Mental Rotation and Display Size' (manuscript). 6. Bernt Ivar Olsen, Bruno Laeng, Kari-Ann Kristiansen and Gunnar Hartvigsen: 'Size does matter : females mentally rotate large objects faster than men' (manuscript) 8. Olsen, B.I., Hartvigsen, G, Lund, N.W.: 'Leaving twentiethcentury understanding of documents. From book to eBook to digital ecosystem', 4th IEEE International Conference on Digital Ecosystems and Technologies (2010), pp 600-605. Available at http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=05610589 9. Olsen, B.I., Lund, N.W., Ellingsen, G. & Hartvigsen, G: 'Document theory for the design of socio-technical systems : a document model as ontology of human expression', Journal of Documentation (2012), vol. 68(1):pp.100-126. Available at http://dx.doi.org/10.1108/00220411211200347 10. Olsen, B. I., Kristiansen, K-A., Eldevik, O. P. & Hartvigsen, G.: 'Large, high-resolution displays for co-located collaboration within healthcare : information proliferation for medical decision-making', Presented at INTERACT2009 Workshop: Team meetings within clinical domains – exploring the use of routines and technical support for communication. Uppsala, Sweden (2009). |
| URI: | http://hdl.handle.net/10037/4774 |
| Description: | Papers 1, 3 and 4 of this thesis are not available in Munin: 1. Perez-Garcia C., Feseker T., Mienert J. and Berndt C.: 'The Håkon Mosby Mud Volcano : 330 000 years of focused fluid flow activity at the SW Barents Sea slope', Marine Geology (2009), vol.262:105-115. Available at http://dx.doi.org/10.1016/j.margeo.2009.03.022 3. Haffert L., Haeckel M., V. Liebetrau, C. Berndt, M. Nuzzo, A. Reitz, F. Scholz, J. Schönfeld, C. Perez-Garcia and S.M. Weise: 'Fluid evolution and authigenic mineral paragenesis related to salt diapirism : the Mercator mud volcano in the Gulf of Cadiz' (manuscript). 4. Perez-Garcia, C., Safronova, P., Mienert, J., Berndt, C. and Andreassen, K.: 'Extensional rise and fall of a salt diapir in the Sørvestsnaget Basin, SW Barents Sea' (manuscript) |
| URI: | http://hdl.handle.net/10037/4648 |
| Abstract: | Protein fosforylering er en av de viktigste intracellulære signaltransduksjonsmekanismer i eukaryote og er involvert i nesten alle cellulære prosesser. Avvikende kinase aktivitet kan forårsake mange alvorlige sykdommer som diabetes og kreft. Bruk av små molekyler for å modulere protein kinase aktivitet er nå en validert metode for behandling av slike sykdommer. Men imidlertid har kliniske studier med denne typen stoffer ofte avslørt alvorlige bivirkninger, sannsynligvis forårsaket av uspesifikke effekter på andre kinaser. Ettersom det menneskelige kinome omfatter mer enn 500 kinaser, vil en bedre forståelse av presise strukturelle mekanismer for hemmer selektivitet være et viktig hjelpemiddel i utformingen av nye legemidler. |
| Description: | Paper 1 and 2 of this thesis are not available in Munin: 1. Alexander Pflug, Jevgenia Rogozina, Darja Lavogina, Erki Enkvist, Asko Uri, Richard Alan Engh and Dirk Bossemeyer: 'Diversity of bisubstrate binding modes of adenosine analogue–oligoarginine conjugates in protein kinase A and implications for protein substrate interactions', Journal of Molecular Biology (2010), 403:66–77. Available at http://dx.doi.org/10.1016/j.jmb.2010.08.028 2. Alexander Pflug, Taianá Maia de Oliveira, Dirk Bossemeyer and Richard A. Engh: 'Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase', Biochemical Journal (2011), 440:85–93. Available at http://dx.doi.org/10.1042/BJ20110592 |
| URI: | http://hdl.handle.net/10037/4145 |
| Abstract: | What causes the escape of natural gases to the seafloor and how significant this escape has been along the mid-Norwegian continental margin? These are questions that guided the doctoral thesis. The thesis is part of a research project supported by the European Commission and the Norwegian Research Council, which aims at quantifying geological processes that control fluid flow and gas hydrate formation along the Norwegian-Barents-Svalbard margin. The thesis was divided in three stages according to the following three main objectives: (1) to assess the distribution of shallow gas reservoirs and paths for fluid migration from deep sources; (2) to investigate the internal structure of a vertical fluid escape feature (chimney) through implementation of high resolution travel-time reflection tomography modeling; and (3) to infer a time scale for fluid escape in the region through detailed seismic characterization of depositional settings and sediment deformation of sediments deposited during the last three major glaciations and their inter-glacial cycles. The methodology implemented consists in the integration of velocity analysis techniques and seismic imagine applied to different resolution seismic data sets. The thesis presents results from four articles that together bring us closer to the overall understanding of fluid flow related systems in Nyegga, offshore mid-Norway. While each article has separate and specific aims, the problems and results covered by the four articles are nevertheless guided by a single motive: to access geophysical and geological indications of sub-seabed fluid flow processes by the implementation of non-invasive methods. Two of the most important results encountered are first, that gas hydrates are at present hindering catastrophic escapes of fluids towards the seafloor; and second that fluid escape in the margin has seemingly been episodically. Fluid escape periods seem to be related to overpressure generation during the last three glaciations. |
| Description: | Paper number 1 and 2 of the thesis are not available in Munin due to publishers' restrictions:
1. Plaza-Faverola, A., S. Bünz, and J. Mienert (2010). "Fluid distributions inferred from Pwave velocity and reflection seismic amplitude anomalies beneath the Nyegga pockmark field of the mid-Norwegian margin", Marine and Petroleum Geology, 27(1): 46-60 2. Plaza-Faverola, A., G. K. Westbrook, K. Stephan, R. Exley, A. Gailler, T. Minshull and K. Broto, (2010). "Evidence from tomographic investigation of Vp variation for accumulation of substantial methane hydrate in a fluid-escape chimney in the Nyegga pockmark field, offshore Norway". JGR solid earth. v. doi:10.1029/2009JB007078, in press. |
| URI: | http://hdl.handle.net/10037/2812 |
| Abstract: | The thesis consists of four parts and its four main objectives are: (1) to establish a potential link between serpentinization beneath a young sedimented-ocean ridge and carbon release and gas hydrate formation directly above it, (2) to understand the coexistence of free gas and gas-hydrate and to image the geophysical evidence for a geologically controlled gas hydrate, fluid migration pathway and seabed expulsion system, (3) to image the active fluid flow migration path-networks from deep hydrocarbon sources and to assess the distribution of shallow gas accumulation, and (4) to determine in detail the seismic velocity structure of the regions close to the landward limit of hydrate stability zone. The methodology implemented to realize this aims was achieved by integrating 3D seismic imaging, 1D velocity modeling to 2D seismic imaging and bathymetric and oceanographic data mapping. This PhD thesis presents results from four articles that glean into the fluid flow and gas-hydrate systems of the NW-Svalbard and SW-Barents Sea margins. The important results found during this research are: (1) new evidence for carbon release from the deep-seated source rock through the sediments above diapirism and methane capture in the inferred areas of serpentinization at the Knipovich Ridge, (2) new geophysical evidence for gas migration and geologically controlled gas hydrate system offshore NW-Svalbard, where several existing glacigenic debris flow units, which are spatially confined and influence gas migration pathways and hence, the location of gas leakage zones at the seafloor and (3) first findings of the formation of “tilted” bottom-simulating reflector in the SW-Barents Sea. They have formed due to variations in fluid flux along regions of deep-seated fault complexes causing a change in heat flow. The data also provides new evidence for the connection of deep-hydrocarbon and shallow gas hydrate, where existing fault complexes apparently act as pathways for the upward migration of fluids. |
| Description: | Papers 2, and 4 of this thesis are not available in Munin: 2. Rajan, A., J. Mienert, and S. Bünz: 'Acoustic evidence for a gas migration and release system in Arctic glaciated continental margins offshore NW-Svalbard', Marine and Petroleum Geology (2012), vol.32(1):36-49. Available at http://dx.doi.org/10.1016/j.marpetgeo.2011.12.008 3. Anupama Rajan, Stefan Bünz, Jürgen Mienert and. Andrew J. Smith: 'Tilted bottomsimulating reflectors (TBSRs) provide evidence for active fluid flow from deep hydrocarbon sources in the SW-Barents Sea' (manuscript) 4. Anupama Rajan, Tim A. Minshull and Jürgen Mienert: 'Heterogeneous distribution of gashydrate and free gas in glaciated sediments of the NW-Svalbard continental margin inferred from changes in compressional wave velocity' (manuscript). |
| URI: | http://hdl.handle.net/10037/5149 |
| Abstract: | NORSK SAMANDRAG:
Denne avhandlinga tek for seg endringane i relativt havnivå – strandforskyvinga – dei siste vel 11.500 åra på kysten av Finnmark og i midtre Hardanger. Ei stor mengd kjerneprøver frå avsettingane i innsjøar som ein gong låg under havnivået, er henta inn og analysert. Grenser mellom sediment som vart avsett i salt- eller ferskvatn er bestemt ved å analysere både kiselalgar og restar etter daude dyr og planter, og tidfest ved hjelp av radiokarbondatering. I lag med presist oppmålte høgder på innsjøtersklane, gjer desse data det mogleg å rekonstruere havnivåendringane i høg detalj. Her blir det presentert havnivåkurver som syner utviklinga i fire område; Tørvikbygd i Hardanger, Sørøya og Rolvsøya i vest-Finnmark og Nordkinnhalvøya i aust-Finnmark. Desse dokumenterer samspelet mellom landheving og havnivåstiging – stort sett har landhevinga vore sterkast, men i tida mellom ca. 9-7000 år sidan var det motsette tilfelle på finnmarkskysten – da vart fleire innsjøar atter oversvømt etter å ha lege fleire tusen år over havnivået. På Rolvsøya steig havnivået opp over ein innsjø men nådde ikkje den neste som ligg rett attmed, berre omlag 60 cm høgare. Her stabiliserte det seg i meir enn tre tusen år, fram til for ca. 5000 år sidan. Etter det har havnivået falle fleire meter fram til i dag. Ei liknande utvikling er òg funne på Sørøya og Nordkinnhalvøya, men i Tørvikbygd er historia ei anna. Her vart landet mykje hardare nedpressa mot slutten av siste istid, og landhevinga har vore tilsvarande sterk, særleg det fyrste tusenåret etter at isen forsvann – da datt strandlina gjennomsnittleg med meir enn 5 cm i året. Breen som dekte Barentshavet under siste istid, smelta vekk tidlegare enn isen over Finnmark. Dette førte til sterk heving av havbotnen som også virka inn på tidleg isfrie område av ytterkysten og medførte at spranget mellom marin grense og yngre strandliner er langt større her enn langs andre delar av norskekysten. I tillegg er bidraget til hevinga frå Barentshavet, truleg i lag med ein slakare profil på innlandsisen, årsaka til at dei heva strandlinene i Finnmark hallar mindre enn dei gjer t.d. på Vestlandet. Det er funne klåre spor etter ein tsunami i fem av innsjøane på Finnmarkskysten. Dateringar syner at dette må ha vore Storeggatsunamien, som vart utløyst av eit enormt undersjøisk skred utafor Mørekysten for om lag 8100-8200 år sidan. Bølgja slo opp i alle fall 3-4 meter i høgda, og mange hundre meter innover land. Erosjonen var sterkast nært sjøen der tsunamien grov sed ned i meir enn 3000 år eldre avleiringar. Over erosjonskontakten ligg nedst eitt sandlag, fylgd av mellom anna opprivne torvbitar og gytjeklumpar som tydeleg har rulla i sanda. Den valdsamme erosjonen og dei sorterte avsettingane tilseier at tsunamien må ha råka 17 innsjøar som ikkje var islagte, og på denne tida var klimaet vesentleg kaldare enn i dag. Dette gjer det truleg at både Storeggaskredet og tsunamien hende ein gong mellom april og oktober. |
| Description: | Paper number 1 of the thesis is not available in Munin due to publisher's restrictions:
1. Romundset, A., Lohne, Ø.S., Mangerud, J. & Svendsen, J.I.: «The first Holocene relative sea-level curve from the middle part of Hardangerfjorden, western Norway», Boreas 39(2010), 87-104 (Wiley). Available at http://dx.doi.org/10.1111/j.1502-3885.2009.00108.x |
| URI: | http://hdl.handle.net/10037/2703 |
| Abstract: | The scope of this PhD thesis is twofold: Firstly, processes, patterns and timing of the last deglaciation in the Barents Sea are reconstructed and secondly, depositional conditions on the Barents shelf during Holocene are elucidated. This cumulative PhD thesis encompasses an introductory part and five papers - three as first-author and two as co-author. Three papers are focused on the most prominent geomorphological freature of the western Barents shelf, 850 km long cross-shelf trough Bjørnøyrenna (The Bear Island Trough). One detailed study examines processes and timing of the first step of glacial retreat in outer Bjørnøyrenna and establishes a minimum age of 17 cal ka for initial deglaciation. A second study focuses on a grounding line system in uppermost Bjørnøyrenna, witnessing a surge-type readvance towards the final collapse of the marine-based Barents Sea Ice Sheet. A third study focuses on contrasting ice stream flow regimes and processes observed from glacial maximum over initial deglaciation towards final deglaciation. Two additional studies are located in the relatively small formerly glaciated trough Kveithola, north-west of Bjørnøya (Bear Island). The first focuses on the most recent deglaciation history and establishes an indirect deglaciation age for Spitsbergenbanken 14.2-13.9 cal ka ago. The other reconstructs the complex glacial retreat through Kveithola and associated processes based on geophysical data. As a whole, this PhD thesis improves existing chronology during deglaciation and Holocene for the Barents Sea, advances existing depositional models of ice-marginal and deglacial processes as well as it adds to established conceptional models of glacial retreat. While presented Holocene data is less conclusive, it might create the awareness that the large Storegga tsunami at 8.2 cal ka may have had an erosional impact on shelf sediments and thereby motivate further research. |
| Description: | The papers of this thesis are not available in Munin: 1. Rüther, D. C., Mattingsdal, R., Andreassen, K., Forwick, M. and Husum, K.: 'Seismic architecture and sedimentology of a major grounding zone system deposited by the Bjørnøyrenna Ice Stream during Late Weichselian deglaciation', Quaternary Science Reviews (2011) vol.30:2776-2792. Available at http://dx.doi.org/10.1016/j.quascirev.2011.06.011 2. Rüther, D. C., Bjarnadóttir, L. R. Junttila, J., Husum, K., Rasmussen, T., Lucchi, R. G. and Andreassen, K.: 'Pattern and timing of the north-western Barents Sea Ice Sheet deglaciation and indications of episodic Holocene deposition' (accepted paper in Boreas). 3. Bjarnadóttir, L. R., Rüther, D. C., Winsborrow, M. C. M. and Andreassen, K.: 'Grounding line dynamics during the last deglaciation of Kveithola, W Barents Sea, as revealed by seabed geomorphology and shallow seismic stratigraphy' (submitted manuscript to Boreas). 4. Andreassen, K., Winsborrow, M. C. M., Bjarnadóttir, L. R. and Rüther, D. C.: 'Landform assemblage from the collapse of a marine-based ice stream' (submitted manuscript to Geology). 5. Rüther, D. C., Andreassen, K. and Winsborrow, M. C. M.: 'Changing ice stream flow regimes during the last deglaciation of Bjørnøyrenna, western Barents Sea' (manuscript) |
| URI: | http://hdl.handle.net/10037/3876 |
| Abstract: | The overall aim of the thesis was to study immunological effects of pollutants in Barents Sea. The Glaucous gull (Larus hyperboreus), black-legged kittiwake (Rissa tridactyla) and Atlantic puffin (Fratercula arctica) were studied. The apex predatory glaucous gull have high levels of persistent organic pollutants (POPs), while the fish eating black-legged kittiwake and Atlantic puffin are located lower in the food-chain and have lower levels of POPs. In breeding glaucous gulls, positive correlations between levels of intestinal nematode and organochlorine (OC) levels were observed. The intestinal parasite intensities could be seen as an end result of the immune system’s battle against the establishment and survival of the parasites. An increased infection with increased OC levels might be explained by immune suppression activity of OCs. The influence of the Barents Sea’s POP-cocktails on the developing immune system was studied on laboratory-raised glaucous gull chicks. The polluted group that simulated “naturally” polluted glaucous gull chicks responded less well to an influenza vaccine and had lower levels of circulating immunoglobulin-G (IgG) and IgM than the control group. The hypothesis of a POP-induced immune suppression was also investigated in the less polluted black-legged kittiwake and Atlantic puffin. The predictions of an altered level of circulating IgG with OCP, PCB or PBDE levels were tested. The results show no indication of correlations between the IgG and pollutant levels. Naturally dead glaucous gulls were studied in an attempt to evaluate whether pollutants contribute to the death. Autopsies and POP analyses reveal that the brain levels of pesticides and PCBs were the same as in a sample of dead glaucous gulls from 1989, while the liver levels were significantly lower. The brain levels thereby strengthen the theory that an additional stress provided from elevated pollutant levels could be deadly. |
| Description: | Papers number 1,2 and 3 of the thesis are not available in Munin due to publishers' restrictions. Paper 4 is a manuscript, and not available in Munin. 1. Sagerup, K., Henriksen, E.O., Skorping, A. Skaare, J.U., Gabrielsen G.W.: "Intensity of parasitic nematodes is associated with organochlorine levels in the glaucous gull (Larus hyperboreus)." Jornal of Applied Ecology 2000; 37: 532-239 (British Ecology Society). Available at http://dx.doi.org/10.1046/j.1365-2664.2000.00521.x 2. Sagerup, K., Larsen, H.J.S., Skaare, J.U., Johansen, G.M., Gabrielsen, G.W.: "The toxic effects of multiple persistent organic pollutant exposures on the post-hatch immunity maturation of glaucous gulls." Journal of Toxicology and Environmental Health - Part A 2009; 72: 1-14 (Taylor & Francis). Available at http://dx.doi.org/10.1080/15287390902959516 3. Sagerup, K., Savinov, V., Savinova, T., Kuklin, V.V., Muir, D.C.G., Gabrielsen, G.W.: "Persistent organic pollutants, heavy metals and parasites in the glaucous gull (Larus hyperboreus) on Spitsbergen." Environmental Pollution 2009; 157(8-9): 2282-2290 (Elsevier). Available at http://dx.doi.org/10.1016/j.envpol.2009.03.031 4. Sagerup, K., Åsbakk, K., Polder A., Skaare, J.U., Gabrielsen, G.W., Barrett, R.T.: "The effect of persistent organic pollutants (POPs) on the immune system of black-legged kittiwakes and Atlantic puffins in the Barents Sea." Manuscript. |
| URI: | http://hdl.handle.net/10037/2244 |
| Abstract: | This thesis presents several signal processing techniques applied to the enhancement of marine seismic data. Marine seismic exploration provides an image of the Earth's subsurface from reflected seismic waves. Because the recorded signals are contaminated by various sources of noise, minimizing their effects with new attenuation techniques is necessary. A statistical analysis of background noise is conducted using Thomson’s multitaper spectral estimator and Parzen's amplitude density estimator. The results provide a statistical characterization of the noise which we use for the derivation of signal enhancement algorithms. Firstly, we focus on single-azimuth stacking methodologies and propose novel stacking schemes using either enhanced weighted sums or a Kalman filter. It is demonstrated that the enhanced methods yield superior results by their ability to exhibit cleaner and better defined reflected events as well as a larger number of reflections in deep waters. A comparison of the proposed stacking methods with existing ones is also discussed. We then address the problem of random noise attenuation and present an innovative application of sparse code shrinkage and independent component analysis. Sparse code shrinkage is a valuable method when a noise-free realization of the data is generated to provide data-driven shrinkages. Several models of distribution are investigated, but the normal inverse Gaussian density yields the best results. Other acceptable choices of density are discussed as well. Finally, we consider the attenuation of flow-generated nonstationary coherent noise and seismic interference noise. We suggest a multiple-input adaptive noise canceller that utilizes a normalized least mean squares alg orithm with a variable normalized step size derived as a function of instantaneous frequency. This filter attenuates the coherent noise successfully when used either by itself or in combination with a time-frequency median filter, depending on the noise spectrum and repartition along the data. Its application to seismic interference attenuation is also discussed. |
| URI: | http://hdl.handle.net/10037/2794 |
| Description: | Papers 1, 3 and 4 are not available in Munin. 1. Dmitry Shcherbin and Kenneth Ruud: 'The use of Coulomb-attenuated methods for the calculation of electronic circular dichroism spectra', Chemical Physics (2008), Volume 349, Issues 1-3, Pages 234-243. Available at http://dx.doi.org/10.1016/j.chemphys.2008.02.029 3. Antonio Rizzo, Dmitry Shcherbin and Kenneth Ruud: 'Jones and magnetoelectric birefringence of pure substances A computational study', Canadian Journal of Chemistry (2009), Volume 87, Number 10, pp. 1352-1361(10). Available at http://dx.doi.org/10.1139/V09-087 4. Dmitry Shcherbin, Andreas J. Thorvaldsen, Dan Jonsson and Kenneth Ruud: 'Gauge-origin independent calculations of Jones birefringence' (manuscript) |
| URI: | http://hdl.handle.net/10037/3572 |
| Abstract: | The manual trimming and inspection of cod fillets by candling, is considered the bottleneck of cod fillet processing. The operation is both labour intensive and expensive, reported to account for as much as 50 % of the cost with cod fillet production. Due to the high labour costs in Norway, it is of great interest for the industry to optimize this process. In this work a hyperspectral imaging system has been developed, capable of inspecting cod fillets, with or without skin, at a conveyor belt speed of 400 mm/seconds, corresponding to the industrial processing speed of one fish per second. The system is designed as proof of concept, and the algorithms are not implemented to be run in real time. A method for segmenting a cod fillet image into the respective parts: loin, belly and tail, using the centerline as a reference system, has been developed. The method is useful for selecting standardized measurement regions on the fillet, and used for extracting data for automatic freshness assessment. Freshness, as days on ice, can be predicted using spectroscopy in part of the visible region (450-700 nm). This can be done with an accuracy comparable to what is reported for sensory evaluation using a panel of trained evaluators. The same system is used for detecting fillets which have been previously frozen, both as whole fish and as fillets with skin. The results show a complete separation between the fresh and frozen-thawed samples. Similar mechanisms are affecting the spectra from fish stored fresh on ice, and fish that has been through the freeze-thaw cycle. The main variations seen in the spectra from cod fillets stored on ice, or frozen and then thawed, are due to oxidation of heme proteins in the muscle. This is supported by independent measurements using two different instruments, and by previous studies pointing to the visible region as the best region for freshness prediction. Detectingobjectsembeddedintissue, usingvisiblelight, isdifficultduetovariability in the optical properties of the surrounding tissue. A method for calibrating the spectral signature from small objects embedded in translucent material has been developed. This method uses the estimated local background spectrum to calibrate the hyperspectral image, and the method is evaluated for automatic nematode detection, using the hyperspectral imaging system, at a commercial cod fillet processing plant. The local calibration method is superior to using traditional spectroscopic pre-treatment methods, and reduces both spatial and spectral variations across the image. The results from the industrial test show that the system can detect nematodes in cod fillets with a performance which is comparable or better, to what is reported by manual inspection. |
| Description: | The papers of this thesis are not available in Munin: 1. A. H. Sivertsen, C. Chu, L. Wang, F. Godtliebsen, K. Heia and H. Nilsen: 'Ridge detection with application to automatic fish fillet inspection', Journal of Food Engineering (2009), vol. 90, pp. 317–324. Available at http://dx.doi.org/10.1016/j.jfoodeng.2008.06.035 2. A. H. Sivertsen, K. Heia, S. K. Stormo, E. Elvevoll and H. Nilsen: 'Automatic nematode detection in cod fillets (Gadus Morhua) by transillumination hyperspectral imaging', Journal of Food Science (2011), vol. 76, pp. 77-83. Available at http://dx.doi.org/10.1111/j.1750-3841.2010.01928.x 3. A. H. Sivertsen, K. Heia, K. Hindberg and F. Godtliebsen: 'Automatic nematode detection in cod fillets (Gadus Morhua L.) by hyperspectral imaging' Journal of Food Science (2011), Volume 76, Issue 1, pages S77–S8. Available at http://dx.doi.org/10.1111/j.1750-3841.2010.01928.x 4. A. H. Sivertsen, T. Kimiya and K. Heia: 'Automatic freshness assessment of cod (Gadus morhua) fillets by VIS/NIR spectroscopy', Journal of Food Engineering (2011), vol 103, pp. 317-323. Available at http://dx.doi.org/10.1016/j.jfoodeng.2010.10.030 |
| URI: | http://hdl.handle.net/10037/3681 |
| Abstract: | This thesis is concerned with synthetic aperture focusing of ultrasonic pulse-echo measurements, with application to multilayered media and cylindrical structures. The work is motivated by the need for accurate methods for non-destructive testing of pipelines, particularly water distribution pipelines. By improving the lateral resolution in ultrasonic measurements, the synthetic aperture algorithms presented in the thesis enable accurate detection and sizing of corrosion damage, holes, and other pipe defects. In ultrasonic inspection of water-filled pipelines, the water and the pipe wall constitute a multilayered structure, and multilayer synthetic aperture algorithms are therefore needed. We present a number of such multilayer algorithms, formulated in both the time and Fourier domains, and show that the Fourier-domain algorithms generally require a significantly lower processing time. An algorithm combining two algorithms used in reflection seismology is shown to require the least processing time for large data sets. When the synthetic aperture is created by scanning over a straight line or a flat plane, and the propagating medium is homogeneous, the lateral resolution after focusing is approximately half the transducer diameter. We show that this resolution limit also applies in the multilayer case, for both two- and three-dimensional imaging, as long as the transducer beam is relatively narrow. Ultrasonic measurements for pipe inspection are usually performed over a cylindrical surface. We develop a new synthetic aperture algorithm, termed cylindrical phase shift migration, to focus such scans. The algorithm is applicable to concentrically layered media, and thus enables full volumetric synthetic aperture imaging in pipes and similar structures. It is shown that the lateral resolution along the cylinder axis is approximately half the transducer diameter, and that the angular resolution is approximately D/(2R), where D denotes transducer diameter and R denotes scan radius. The algorithm is also adapted for use with focused transducers, and it is shown that it significantly extends the range within which the transducer yields a high lateral resolution. |
| URI: | http://hdl.handle.net/10037/4649 |
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