Now showing items 1-20 of 21

    • Alcohol consumption, types of alcoholic beverages and risk of Venous Thromboembolism : the Tromsø Study 

      Hansen-Krone, Ida Johanne; Brækkan, Sigrid K.; Enga, Kristin F.; Wilsgaard, Tom; Hansen, John-Bjarne (Master thesis; Mastergradsoppgave, 2011-11-01)
      Moderate alcohol consumption has been shown to protect against cardiovascular diseases. The association between alcohol consumption, especially types of alcoholic beverages, and venous thromboembolism (VTE) is less well described. The aim of this study was to investigate the impact of alcohol consumption and different alcoholic beverages on risk of VTE. Information on alcohol consumption were ...
    • Cabin temperature during prehospital patient transport – a prospective observational study from Northern Norway 

      Svendsen, Tuva (Master thesis; Mastergradsoppgave, 2019-11-01)
      Background Few studies have investigated the patient compartment temperatures during ambulance missions or its relation to admission hypothermia. Still hypothermia is a known risk factor for increased mortality and morbidity in both trauma and disease. This has special relevance to our sub-arctic region’s pre-hospital services, and we prospectively studied the environmental temperature in the patient ...
    • Coffee consumption and the risk of Venous Thromboembolism – The Tromsø study 

      Enga, Kristin (Master thesis; Mastergradsoppgave, 2011-11-01)
      Background: Several studies have investigated the association between coffee consumption and cardiovascular disease, but little is known about coffee intake and risk of venous thromboembolism (VTE). Objective: The aim of this prospective cohort study was to investigate the association between coffee consumption and risk of incident VTE in a general population. Methods: Information about coffee ...
    • Early fulminant BK polyomavirus-associated nephropathy in two kidney transplant patients with low neutralizing antibody titers receiving allografts from the same donor 

      Lorentzen, Elias Myrvoll; Henriksen, Stian; Kaur, Amandeep; Kro, Grete Birkeland; Hammarström, Clara; Hirsch, Hans H; Midtvedt, Karsten; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed; Mastergradsoppgave; Master thesis, 2020-01-10)
      <i>Background</i> - BK Polyomavirus (BKPyV) causes premature graft failure in 1 to 15% of kidney transplant (KT) recipients. High-level BKPyV-viruria and BKPyV-DNAemia precede polyomavirus-associated nephropathy (PyVAN), and guide clinical management decisions. In most cases, BKPyV appears to come from the donor kidney, but data from biopsy-proven PyVAN cases are lacking. Here, we report the early ...
    • EEG-based effective connectivity distinguishes between unresponsive states with and without report of conscious experience and correlates with brain complexity 

      Bremnes, Thomas René; Juel, B.E.; Gosseries, O.; Rosanova, M.; Boly, M.; Laureys, S.; Larsson, P.G.; Massimini, M.; Storm, Johan Frederik (Master thesis; Mastergradsoppgave, 2017-11-01)
      Objective methods for distinguishing conscious from unconscious states in humans are of key importance for clinical evaluation of general anesthesia and patients with disorders or consciousness. Here, we test the generalizability of a DTF-based algorithm - a measure of effective connectivity - as an objective measure of conscious experience during anesthesia and correlate it with a well-tested index ...
    • The effect of high-dose vitamin D3 supplementation on bone mineral density in subjects with prediabetes 

      Larsen, Anette Uhlving; Grimnes, G.; Jorde, R. (Master thesis; Mastergradsoppgave, 2019-10-30)
      Purpose: Type 2 diabetes mellitus is associated with increased fracture risk and recent studies show crosstalk between bone and glucose metabolism. Few studies have investigated the effect of vitamin D supplementation on bone without additional calcium. In the present study, we aimed to determine whether a high dose of vitamin D3 could improve bone mass density (BMD) in prediabetic subjects. Methods: ...
    • The effect of one-hour hypothermia on long term spatial memory in male Long Evans rats 

      Marsteen, Håvar (Master thesis; Mastergradsoppgave, 2020-11-01)
      The human body is willing to expend great amount of energy on mechanisms that keep the core temperature within a very small range. When these mechanisms are overwhelmed the body temperature either rises (hyperthermia) or drops (hypothermia). Hypothermia has earlier been used to induce retrograde amnesia (forgetting) and we have in this study examined if hypothermia can affect a robust long-term ...
    • Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome 

      Grindstad, Thea Karoline Walstad (Master thesis; Mastergradsoppgave, 2016-10-11)
      Androgens are considered important in normal prostate physiology and prostate cancer (PCa) pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking. This indicates additional mediators contributing to cancer development. We sought to determine the prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue microarrays ...
    • Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism 

      Paulsen, Benedikte (Master thesis; Mastergradsoppgave, 2019-10-31)
      Venous thromboembolism is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of venous thromboembolism, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of venous thromboembolism. Cases with incident venous ...
    • Gender differences in hearts subjected to decreased NO-production and elevated blood pressure 

      Kildal, Simon; Ludvigsen, Stian; Norvik, Jon Viljar; Johansen, David; Ytrehus, Kirsti (Master thesis; Mastergradsoppgave, 2016-10-31)
      Hypertension is one of the most important risk factors for heart failure in the general population. Hypertensive heart failure is associated with heart failure with preserved ejection fraction (HFpEF). Women have an increase proportion of HFpEF compared to men. Endothelial dysfunction thereby reduced NO production is proposed to play an important role in the pathophysiology of HFpEF. A suggested ...
    • Hepatic steatosis detected by ultrasonography as a predictor of insulin resistance in obese patients 

      Isaksen, Victoria Therese (Master thesis; Mastergradsoppgave, 2014-10-31)
      Non-alcoholic fatty liver disease is closely related to the Metabolic syndrome. A significant feature of NAFLD is the presence of hepatic steatosis, which can be assessed by ultrasonography, by measuring the hepatorenal index (HRI), a comparison of liver and kidney acoustic echo densities. This study aims to investigate if HRI can predict insulin resistance. Ninety participants from the obesity ...
    • Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study 

      Lerstad, Gunhild (Master thesis; Mastergradsoppgave, 2015-10-23)
      Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) ...
    • Impact of incident venous thromboembolism on risk of arterial thrombotic diseases 

      Lind, Caroline (Master thesis; Mastergradsoppgave, 2015-10-26)
      Background: Growing evidence support an association between venous thromboembolism (VTE) and arterial thrombotic diseases (i.e. myocardial infarction (MI) and ischemic stroke). We aimed to study the association between VTE and future arterial events, and to determine the population attributable risk (PAR%) of arterial events by VTE in a large prospective cohort recruited from the general ...
    • Ischemic stroke and risk of venous thromboembolism in the general population. The Tromsø study 

      Rinde, Ludvig Balteskard (Master thesis; Mastergradsoppgave, 2017-10-21)
      Background: Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort. Methods and Results: Participants (n=30 002) were recruited from ...
    • Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study 

      Småbrekke, Silje; Schirmer, Henrik; Melsom, Toralf; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Master thesis; Mastergradsoppgave, 2019-10-28)
      Background: Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive function in ...
    • Mapping of Nuclear Export Signals and domains mediating aggregation of NBR1 

      Næss, Morten Svendsen (Master thesis; Mastergradsoppgave, 2017-11-02)
      Autophagy is a conserved catabolic pathway for the lysosomal degradation of cytoplasmic components. Autophagy can be both selective and unselective. Selective autophagy receptor proteins are involved in mediating the degradation of specific substrates. Among these receptors we find the evolutionary related proteins p62 and NBR1, which are both involved in autophagic degradation of different ubiquitinated ...
    • Possible origin of a vanB-type Enterococcus faecium causing a multicentre outbreak in Sweden 

      Sivertsen, Audun (Master thesis; Mastergradsoppgave, 2013-11-01)
      Dissemination of vancomycin-resistant Enterococcus faecium (VREfm) with similar pulsed-field gel electrophoresis patterns in three Swedish hospitals between 2007 and 2011 prompted molecular characterization to reveal the possible origins and features of the strain. A representative subset of collected isolates (VREfm (n=18) and vancomycin-susceptible Enterococcus faecium (VSEfm) (n=2)) reflecting ...
    • Pre-test characteristics of unstable angina patients with obstructive coronary artery disease confirmed by coronary angiography 

      Fladseth, Kristina; Kristensen, Andreas; Mannsverk, Jan T.; Trovik, Thor; Schirmer, Henrik (Master thesis; Mastergradsoppgave, 2017-10-31)
      Objective As the mortality and rate of obstructive coronary artery disease (CAD) is low in patients with unstable angina (UA), better pre-test selection criteria for acute coronary angiography (CAG) is warranted. We aimed to validate the current guidelines against other clinical variables as predictors of obstructive CAD in UA patients referred for acute CAG. Methods From 2005 to 2012, all CAGs ...
    • Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carsinoma 

      Wirsing, Anna Maria; Ervik, Ida Korsnes; Seppola, Marit; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson; Hadler-Olsen, Elin (Master thesis; Mastergradsoppgave, 2017-10-31)
      Oral squamous cell carcinomas (OSCC) are associated with a poor prognosis, which may be partly due to functional impairment of the immune response. Lymphocyte recruitment to the tumor site is facilitated by high-endothelial venules (HEV), whereas expression of programmed-death ligand 1 (PD-L1) can impair T cell function. Thus, we hypothesize that these factors are important in shaping the immune ...
    • Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival 

      Hald, Sigurd M.; Kiselev, Yury; Al-Saad, Samer; Richardsen, Elin; Johannessen, Charles; Eilertsen, Marte; Kilvær, Thomas K.; Al-Shibli, Khalid; Andersen, Sigve; Busund, Lill-Tove; Bremnes, Roy M.; Dønnem, Tom (Master thesis; Mastergradsoppgave, 2015-10-27)
      BACKGROUND: The chemokine CXCL16 and its receptor CXCR6 are expressed by a variety of immune cells and have been shown to influence angiogenesis. The expression of CXCR6 and CXCL16 has been examined in numerous human cancers; however no studies have yet investigated their influence on prognosis in non-small cell lung cancer (NSCLC). We aimed to explore their prognostic significance in NSCLC, in ...