Blar i forfatter Institutt for farmasi "Jøraholmen, May Wenche"

Viser treff 1-11 av 11

    • Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect 

      Jøraholmen, May Wenche; Vanić, Željka; Tho, Ingunn; Škalko-Basnet, Nataša (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      The choice of drug therapy in pregnant patients suffering from vaginal infections is limited by the safety profile of the drug. Assuring the efficient topical therapy to avoid systemic absorption is considered the best therapy option. Chitosan-coated liposomes have been developed and optimized to assure localized therapy of clotrimazole. Chitosan was selected as mucoadhesive polymer both to prolong ...

    • The Expanded Role of Chitosan in Localized Antimicrobial Therapy 

      Hemmingsen, Lisa Myrseth; Skalko-Basnet, Natasa; Jøraholmen, May Wenche (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-08)
      Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the opportunity to prolong the formulation residence time at mucosal sites; its wound healing properties open ...

    • Kan nanopartikulære formuleringer bedre behandlingen av genitale infeksjoner? 

      Jøraholmen, May Wenche; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-20)
      Bruk av nanoteknologi innenfor medisin er økende, og mange nanopartikulære såkalte «drug delivery-systemer» er allerede ute på markedet og enda flere er i pipeline. Det er blant annet stor interesse for bruk av polymeriske miceller, dendrimerer, liposomer og polymeriske nanopartikler som nanobærere for legemidler. Potensialet som ligger i bruk av nanoteknologi er fremdeles ikke fullt utnyttet ...

    • Liposomes-in-hydrogel delivery system enhances the potential of resveratrol in combating vaginal chlamydia infection 

      Jøraholmen, May Wenche; Johannessen, Mona; Gravningen, Kirsten Midttun; Puolakkainen, Mirja; Acharya, Ganesh; Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
      <i>Chlamydia trachomatis</i> is the most common cause of bacterial sexually transmitted infections and causes serious reproductive tract complications among women. The limitations of existing oral antibiotics and treatment of antimicrobial resistance require alternative treatment options. We are proposing, for the first time, the natural polyphenol resveratrol (RES) in an advanced delivery system ...

    • Localized Therapy of Vaginal Infections and Inflammation: Liposomes-In-Hydrogel Delivery System for Polyphenols 

      Jøraholmen, May Wenche; Basnet, Purusotam; Tostrup, Mia; Moueffaq, Sabrin; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-27)
      Natural polyphenols, such as resveratrol (RES) or epicatechin (EPI), are attractive for treatments of various diseases, including vaginal infections and inflammation, because of their strong anti-oxidative and anti-inflammatory properties. However, their low solubility and consequent poor bioavailability limit their therapeutic uses. To overcome these limitations, a vaginal delivery system comprising ...

    • Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance 

      Vanic, Zeljka; Jøraholmen, May Wenche; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-30)
      Recent years have, surprisingly, witnessed an increase in incidence of sexually transmitted infections (STIs). At the same time, antimicrobial therapy came under the threat of ever rising antimicrobial resistance (AMR), resulting in STIs with extremely limited therapy options. In this review, we addressed the challenges of treating vaginal infections in an era of AMR. We focused on published work ...

    • A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel 

      Cacic, Ana; Amidžic Klaric, Daniela; Keser, Sabina; Radikovic, Maja; Rukavina, Zora; Jøraholmen, May Wenche; Uzelac, Lidija; Kralj, Marijeta; Skalko-Basnet, Natasa; Segvic Klaric, Maja; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-28)
      Biocompatible mucoadhesive formulations that enable a sustained drug delivery at the site of action, while exhibiting inherent antimicrobial activity, are of great importance for improved local therapy of vaginal infections. The aim of this research was to prepare and evaluate the potential of the several types of azithromycin (AZM)-liposomes (180–250 nm) incorporated into chitosan hydrogel (A ...

    • PEGylated liposomes for topical vaginal therapy improve delivery of interferon alpha 

      Jøraholmen, May Wenche; Basnet, Purusotam; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-11)
      Recent studies regarding mucosal drug delivery indicate that nanosystems with surface-available polyethylene glycol (PEG) are able to penetrate mucus barrier, assure closer contact with the epithelium, and improve drug delivery to vagina. In the present work, we developed the mucus-penetrating PEGylated liposomes containing interferon alpha-2b (IFN α-2b), destined to provide localized therapy for ...

    • Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections 

      Jøraholmen, May Wenche; Skalko-Basnet, Natasa; Acharya, Ganesh; Basnet, Purusotam (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-07)
      Resveratrol (RES), chemically known as 3,5,4′-trihydroxy-trans-stilbene, is a promising multi-targeted antioxidative and anti-inflammatory natural polyphenol. Preclinical studies showed its biological activities against the pathogens of sexually transmitted diseases causing vaginal inflammation and infections. Due to its low solubility and poor bioavailability, the optimal therapeutic uses are ...

    • The Antimicrobial Properties of Chitosan Can be  Tailored by Formulation 

      Jøraholmen, May Wenche; Bhargava, Abhilasha; Julin, Kjersti; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)
      Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in improving localized vaginal therapy by prolonging the residence time of a drug at ...

    • Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginal Tissue Model 

      Jøraholmen, May Wenche; Damdimopoulou, Pauliina; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-17)
      The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydrogel as secondary vehicle. Although considered ...