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Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance

Permanent lenke
https://hdl.handle.net/10037/23006
DOI
https://doi.org/10.1016/j.addr.2021.113855
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article.pdf (6.466Mb)
Publisert versjon (PDF)
Dato
2021-06-30
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Vanic, Zeljka; Jøraholmen, May Wenche; Skalko-Basnet, Natasa
Sammendrag
Recent years have, surprisingly, witnessed an increase in incidence of sexually transmitted infections (STIs). At the same time, antimicrobial therapy came under the threat of ever rising antimicrobial resistance (AMR), resulting in STIs with extremely limited therapy options. In this review, we addressed the challenges of treating vaginal infections in an era of AMR. We focused on published work regarding nanomedicine destined for localized treatment of vaginal infections. Localized therapy offers numerous advantages such as assuring high drug concentration at the infection site, limiting systemic drug exposure that can lead to faster development of AMR reduction in the systemic side effects and potentially safe therapy in pregnancy. We provided a state-of-the-art overview of nanoformulations proposed to topically treat STIs, emphasizing the challenges and advantages of each type of nanocarriers, as well as issues of potential toxicity.
Forlag
Elsevier
Sitering
Vanic, Jøraholmen, Skalko-Basnet. Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance. Advanced Drug Delivery Reviews. 2021
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  • Artikler, rapporter og annet (farmasi) [394]
Copyright 2021 The Author(s)

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