Natural polyphenols are promising alternatives to antifungals for novel treatments of vulvovaginal candidiasis (VVC) in an era of antimicrobial resistance. However, polyphenols are poorly soluble and prone to degradation. To overcome their limitations, we propose incorporation in liposomes. The study aimed to develop chitosan and liposome comprising delivery systems for epicatechin (EC) or propyl ...

Short-Patch Double Illegitimate Recombination (SPDIR) has been recently identified as a rare mutation mechanism. During SPDIR, ectopic DNA single-strands anneal with genomic DNA at microhomologies and get integrated during DNA replication, presumably acting as primers for Okazaki fragments. The resulting microindel mutations are highly variable in size and sequence. In the soil bacterium Acinetobacter ...

The study of intact phase II metabolites of endogenous anabolic androgenic steroids (EAAS) gives important information about metabolism and has the potential to improve the detection of doping with testosterone. For analysis with liquid chromatography–mass spectrometry (LC-MS), chemical derivatization at the steroid moiety is a technique to improve the positive ionization efficiency of glucuronida ...

Background: Machine learning (ML) prediction models in healthcare and pharmacy-related research face challenges with encoding high-dimensional Healthcare Coding Systems (HCSs) such as ICD, ATC, and DRG codes, given the trade-off between reducing model dimensionality and minimizing information loss. Objectives: To investigate using Network Analysis modularity as a method to group HCSs to improve ...

Background Dementia is a major global public health challenge, and with the growing elderly population, its prevalence is expected to increase in the coming years. In Sweden, municipalities are responsible for providing special housing for the elderly (SÄBO), which offers services and care for older individuals needing specific support. SÄBO is both the person´s home and a care environment and ...

The diatom lipidome actively regulates photosynthesis and displays a high degree of plasticity in response to a light environment, either directly as structural modifications of thylakoid membranes and protein–pigment complexes, or indirectly via photoprotection mechanisms that dissipate excess light energy. This acclimation is crucial to maintaining primary production in marine systems, particularly ...

Pembrolizumab monotherapy for non-small cell lung cancer (NSCLC) was deemed not cost-effective due to limited data, high uncertainty regarding long term results and a considerable budget impact. However, due to confidential price agreements it was approved in 2017, as first-line treatment for metastatic NSCLC that expresses PD-L1 ≥ 50 %. Given potential discrepancies between clinical efficacy and ...

Background The effect of antibiotic usage on the success of multidrug-resistant (MDR) clones in a population remains unclear. With this genomics-based molecular epidemiology study, we aimed to investigate the contribution of antibiotic use to Escherichia coli clone success, relative to intra-strain competition for colonisation and infection.<p> <p>Methods We sequenced all the available E coli ...

In 2015, UiT The Arctic University of Norway and a local smelting plant initiated a project aiming to reduce the carbon footprint by mass cultivation of microalgae. The ability of the microalgae to directly capture industrially emitted CO2 and utilize wastewater as alternative nutrient sources to produce high value biomass, causes the bio-carbon recycling to represent both an environmental and ...

Bakgrunn: Apotekbransjen og farmasøytrollen er stadig i endring, og i de siste årene har flere og flere farmasøytiske tjenester blitt implementert i apotek. Dette har ført til større fokus på legemiddelveiledning og formidling av legemiddelinformasjon, samt apotek som et lavterskeltilbud innen helse. I 2018 åpnet Stortinget for å fjerne reseptplikten på enkelte legemidler, slik at de kunne selges ...