Gonadotropin-releasing hormone receptor (GnRH-R), which is a Class A G-protein coupled receptor (GPCR), has a vital role in the regulation of sex hormones. The receptor also has a prominent role in diseases, with examples being reproductive cancers and non-reproductive cancers like glioblastoma. Gonadotropin-releasing hormone (GnRH) agonists have been proven to combat cell proliferation in cancers. ...

Today, Wikipedia has developed into a prominent source for health queries to the vast public. Over the years, some studies have been performed to understand what the webpage can and cannot offer. However, the current literature lacks knowledge of how the pharmaceutical industry is present in Wikipedia’s medicine articles. The immediate objective of this research was to quantify the presence of ...

Over-the-counter (OTC) medications are products that have been made easily accessible to allow patients to treat common ailments without a prescription and the cost of a doctor’s visit. These medications are generally considered safe; however, there is still a potential for these medications to lead to adverse health outcomes. Older adults (ages 50+) are especially susceptible to these adverse health ...

Introduction - It is important to understand the factors impacting the quality of services provided through community pharmacies. Exploring how key stakeholders perceive good quality in these services is a logical first step. This could also inform the development of quality measures, such as quality indicators (QIs).<p> <p>Aim - To identify key stakeholders' perspectives on the quality of services ...

Polyethylene glycol (PEG) conjugation (PEGylation) is a well-established strategy to improve the pharmacokinetic and biocompatibility properties of a wide variety of nanomedicines and therapeutic peptides and proteins. This broad use makes PEG an attractive ‘allround’ candidate marker for the biodistribution of such PEGylated compounds. This paper presents the development of a novel strategy for ...

Background - Older adults are at greater risk of medication-related harm than younger adults. The Integrated Medication Management model is an interdisciplinary method aiming to optimize medication therapy and improve patient outcomes.<p> <p>Objective - We aimed to investigate the cost effectiveness of a medication optimization intervention compared to standard care in acutely hospitalized older ...

Nucleic acid-based materials showcase an increasing potential for antimicrobial drug delivery. Although numerous reports on drug-loaded DNA nanoparticles outline their pivotal antibacterial activities, their potential as drug delivery systems against bacterial biofilms awaits further studies. Among different oligonucleotide structures, micellar nanocarriers derived from amphiphilic DNA strands ...

Objective - To explore Norwegian GPs’ experiences with and perceived suitability of issuing sickness certifications in remote consultations during the COVID-19 pandemic.<p> <p>Design - We used a mixed methods research design. An online survey with 301 respondents was combined with qualitative interviews with ten GPs.<p> <p>Setting - Norwegian general practice.<p> <p>Results - Most GPs agreed ...

Natural transformation is a process where bacteria actively take up DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. The evolutionary benefits of transformation are still under debate. One main explanation is that foreign allele and gene uptake facilitates natural selection by increasing genetic variation, analogous to meiotic ...

Hydrogels are currently applied as the vehicles for drugs or active substances, rather than the active contributors to therapeutic activities. With increasing challenges related to antimicrobial resistance against many antibiotics, natural origin hydrogels have become attractive as more than just vehicles. Although many natural polymers exhibit intrinsic antimicrobial properties, these properties ...