Institutt for farmasi: Nye registreringer
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Suitability of issuing sickness certificates in remote consultations during the COVID-19 pandemic. A mixed method study of GPs' experiences
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)Objective - To explore Norwegian GPs’ experiences with and perceived suitability of issuing sickness certifications in remote consultations during the COVID-19 pandemic.<p> <p>Design - We used a mixed methods research design. An online survey with 301 respondents was combined with qualitative interviews with ten GPs.<p> <p>Setting - Norwegian general practice.<p> <p>Results - Most GPs agreed ... -
Pharmaceutical Care Network Europe definition of quality indicators for pharmaceutical care: a systematic literature review and international consensus development
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-30)Background Over the past 40 years, the tasks of pharmacists have shifted from logistic services to pharmaceutical care (PhC). Despite the increasing importance of measuring quality of care, there is no general defnition of Quality Indicators (QIs) to measure PhC. Recognising this, a working group in a European association of PhC researchers, the Pharmaceutical Care Network Europe (PCNE), was ... -
Testing for the fitness benefits of natural transformation during community-embedded evolution
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-01)Natural transformation is a process where bacteria actively take up DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. The evolutionary benefits of transformation are still under debate. One main explanation is that foreign allele and gene uptake facilitates natural selection by increasing genetic variation, analogous to meiotic ... -
A new preparation method for preparation of liposomes-in-hydrogels primed for treatment of skin diseases
(Conference object; Konferansebidrag, 2014)<p>Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization. <p>Liposome formulations for topical application needs a vehicle to assure the desirable ... -
Chapter 11 - Hydrogels as intrinsic antimicrobials
(Chapter; Bokkapittel, 2019-10-25)Hydrogels are currently applied as the vehicles for drugs or active substances, rather than the active contributors to therapeutic activities. With increasing challenges related to antimicrobial resistance against many antibiotics, natural origin hydrogels have become attractive as more than just vehicles. Although many natural polymers exhibit intrinsic antimicrobial properties, these properties ... -
Knowledge and need for information about non-prescription analgesics - A cross-sectional study among pharmacy customers
(Conference object; Konferansebidrag, 2019)<p>Pain is among the most common causes for seeking drug treatment. There is widespread use of non-prescription analgesics, and previous studies suggest that the level of knowledge about these drugs is low. <p>The aim of the study was to describe the level of knowledge about nonprescription analgesics among pharmacy customers, thereby identifying population groups in high need of information. ... -
Dermal Application of Chloramphenicol - The Effect of Liposomes and Chitosan Hydrogel Formulations on ex vivo Permeation and Antimicrobial Activity
(Conference object; Konferansebidrag, 2017)Liposomes solubilize lipophilic drugs in the phospholipid membrane, and entrap hydrophilic drugs in its aqueous core. These vesicles provide a sustained- and targeted- drug release, and protect from degradation. Liposomes retain the drug onto/in the skin and improve skin drug deposition. Due to their liquid nature, a secondary vehicle, such as a hydrogel, is needed to obtain a necessary retention ... -
Docetaxel Liposomes - A formulation Screening Study
(Conference object; Konferansebidrag, 2019)<p>Docetaxel (DOC) is a potent anticancer drug with several limitations, including poor solubility and the reported serious side effects, attributed to either the drug itself or the solvent used. Thus, it is interesting to entrap the drug into liposomes in order to solubilize the drug and improve the therapeutic outcome. <p>The fist aim of this study was to establish a small-scale screening method ... -
Internet Use for Obtaining Medicine Information: Cross-sectional Survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)Background: The internet is increasingly being used as a source of medicine-related information. People want information to facilitate decision-making and self-management, and they tend to prefer the internet for ease of access. However, it is widely acknowledged that the quality of web-based information varies. Poor interpretation of medicine information can lead to anxiety and poor adherence to ... -
‘Illuminating determinants of implementation of non-dispensing pharmacist services in home care: a qualitative interview study’
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-13)Objectives - Medication errors are leading causes of hospitalization and death in western countries and WHO encourages health care providers to implement non-dispensing pharmacist services in primary care to improve medication work. However, these services struggle to provide any impact on clinical outcomes. We wanted to explore health care professionals’ views on medication work to illuminate ... -
α,α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-25)Bacterial biofilms account for up to 80% of all infections and complicate successful therapies due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the industrial sectors, for instance due to the deterioration of metals or microbial contamination of products. Efforts are put in finding novel strategies in both avoiding and fighting biofilms. Biofilm control is ... -
Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-18)Bacterial biofilms are highly protected surface attached communities of bacteria that typically cause chronic infections. To address their recalcitrance to antibiotics and minimise side effects of current therapies, smart drug carriers are being explored as promising platforms for antimicrobials. Herein, we briefly summarize recent efforts and considerations that have been applied in the design ... -
On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-21)ERK3 and ERK4 define a distinct and understudied subfamily of mitogen-activated protein kinases (MAPKs). Little is known about the physiological roles of these atypical MAPKs and their association with human diseases. Interestingly, accumulating evidence points towards a role for ERK3 and ERK4 signaling in the initiation and progression of various types of cancer. Notably, a recent study reported ... -
Patient perceptions and experiences with medication-related activities in the emergency department: a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-22)Background - Emergency department (ED) pharmacists reduce medication errors and improve quality of medication use. Patient perceptions and experiences with ED pharmacists have not been studied. The aim of this study was to explore patients’ perceptions of and experiences with medication-related activities in the ED, with and without an ED pharmacist present.<p> <p>Methods - We conducted 24 ... -
The COVID-19 Pandemic Sparked off a Large-Scale Outbreak of Carbapenem-Resistant Acinetobacter baumannii from the Endemic Strains at an Italian Hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-23)Acinetobacter baumannii is a nosocomial pathogen that poses a serious threat due to the rise of incidence of multidrug-resistant (MDR) strains. During the COVID-19 pandemic, MDR A. baumannii clones have caused several outbreaks worldwide. Here, we describe a detailed investigation of an MDR A. baumannii outbreak that occurred at Policlinico San Matteo (Pavia, Italy). A total of 96 A. baumannii ... -
Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)Whole genome sequencing data of 874 Escherichia coli isolates carrying blaNDM-5 from 13 European Union/ European Economic Area countries between 2012 and June 2022 showed the predominance of sequence types ST167, ST405, ST410, ST361 and ST648, and an increasing frequency of detection. Nearly a third (30.6%) of these isolates were associated with infections and more than half (58.2%) were ... -
Evolutionary and functional history of the Escherichia coli K1 capsule
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, ... -
Hvilke tanker og erfaringer har leger rundt korrekt legemiddelliste og legemiddelbruk til pasienter i akuttmottak? Og hvordan ser de for seg et fremtidig samarbeid med farmasøyt?
(Mastergradsoppgave; Master thesis, 2020-08-01)BAKGRUNN: Legemiddelfeil er et utbredt problem både internasjonalt og nasjonalt, dette kan medfører risiko for pasientsikkerheten. Kliniske farmasøyter er bedre til å oppdage potensielt klinisk relevante uoverensstemmelser enn leger og er blitt mer utbredt på sykehus. De er foreløpig er ikke vanlig på akuttmottak i Norge i motsetning til i andre land. FORMÅL: Formålet med studien er å undersøke ... -
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-07)Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of ... -
Fall hos ortopediske pasienter – sammenligning av to fallscreeningverktøy
(Master thesis; Mastergradsoppgave, 2022-05-12)Bakgrunn og formål: Fall er en av de vanligste rapportere uheldige hendelsene på sykehus. Fall medfører betydelige konsekvenser for pasienten og samfunnet. Fallforebyggende tiltak, som screeningverktøy, er utviklet for å identifisere pasienter med fallrisiko. Hensikten med studien var å sammenligne effekten av screeningverktøyene Downton Fall Risk Index (Downton) og Pasientsikkerhetsprogrammets ...