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A new preparation method for preparation of liposomes-in-hydrogels primed for treatment of skin diseases

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https://hdl.handle.net/10037/31497
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Date
2014
Type
Conference object
Konferansebidrag

Author
Ingebrigtsen, Sveinung Gaarden; Johansen, Kurt Jonny; Skalko-Basnet, Natasa; Holsæter, Ann Mari
Abstract

Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization.

Liposome formulations for topical application needs a vehicle to assure the desirable retention and adhesion of the drug-loaded liposomes onto the skin, and for this, hydrogels are regarded as promising systems. The hydrogel “soluble beta-glucan” (SBG) has caught our attention since it also promotes wound healing on its own.

Dual asymmetric centrifuge (DAC) utilizes a unique combination of two contra rotating movements of the sample-holder, which results in shear forces that efficiently homogenize and gives a size reduction of liposomes. We have investigated the use of DAC for both use in liposome size reduction and for further mixing of liposomes into hydrogels.

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Poster presented at the Liposome Research Days 2014: Living Innovation, at the Technical University of Denmark, Copenhagen, 4-7 August 2014
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Copyright 2014 The Author(s)

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