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A new preparation method for preparation of liposomes-in-hydrogels primed for treatment of skin diseases

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https://hdl.handle.net/10037/31497
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article.pdf (382.3Kb)
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Dato
2014
Type
Conference object
Konferansebidrag

Forfatter
Ingebrigtsen, Sveinung Gaarden; Johansen, Kurt Jonny; Skalko-Basnet, Natasa; Holsæter, Ann Mari
Sammendrag

Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization.

Liposome formulations for topical application needs a vehicle to assure the desirable retention and adhesion of the drug-loaded liposomes onto the skin, and for this, hydrogels are regarded as promising systems. The hydrogel “soluble beta-glucan” (SBG) has caught our attention since it also promotes wound healing on its own.

Dual asymmetric centrifuge (DAC) utilizes a unique combination of two contra rotating movements of the sample-holder, which results in shear forces that efficiently homogenize and gives a size reduction of liposomes. We have investigated the use of DAC for both use in liposome size reduction and for further mixing of liposomes into hydrogels.

Beskrivelse
Poster presented at the Liposome Research Days 2014: Living Innovation, at the Technical University of Denmark, Copenhagen, 4-7 August 2014
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Copyright 2014 The Author(s)

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