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norskInstitutt for farmasi: Nye registreringer
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Impact of multiple stressors on sea bed fauna in a warming Arctic
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-03)The Arctic Barents Sea is experiencing a record temperature increase, a poleward shift in the distributions of commercial fish stocks, and invasion by the snow crab, a new predator. To evaluate benthic community vulnerability when exposed to seawater warming, bottom trawling, and predation from a new predator, we used a trait-based approach and applied this to an extensive dataset of >450 megabenthic ... -
Ulcerative colitis: Functional analysis of the in-depth proteome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)<p><i>Background - </i>Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The cause and the pathophysiology of the disease are not fully understood and we therefor aim in this study to identify important pathophysiological features in UC from proteomics data. <p><i>Methods - </i>Colon mucosa biopsies from inflamed tissue of untreated UC patients at diagnosis and from healthy ... -
Bruk av kosttilskudd blant pasienter over 70 år ved Nordlandssykehuset i Bodø
(Master thesis; Mastergradsoppgave, 2019-05-14)Bruk av kosttilskudd er vanlig i den generelle befolkningen. Kosttilskudd er ikke underlagt de samme lover og reguleringer som legemidler, og det er kjent at kosttilskudd kan gi bivirkninger og interagere med legemidler. Eldre mennesker er en spesielt utsatt gruppe for bivirkninger og interaksjoner. Formålet med studien er å kartlegge bruk av kosttilskudd blant pasienter over 70 år, undersøke om ... -
Isolation and Characterisation of Halogenated and Bioactive Compounds from Thalassospira sp. and Alteromonas sp.
(Master thesis; Mastergradsoppgave, 2019-05-15)Bacterial natural products have contributed with a large part of the bioactive compounds that lead to drugs, and the biggest portion of the marketed antibiotics are bacterial products or their derivatives. Marine bacteria are not yet investigated to the same extend as their terrestrial counterparts. Therefore, they are considered a promising source for novel bioactive metabolites for drug development, ... -
Development of a homologous gene replacement approach to study ciprofloxacin resistance in clinical Escherichia coli isolates
(Master thesis; Mastergradsoppgave, 2017-05-15)Urinary tract infections are common amongst infectious diseases in humans, and often these infections are caused by uropathogenic Escherichia coli. Effective antimicrobial treatment of infections are medical achievements that should not be taken for granted, as antimicrobial resistance has developed and causes treatments to become ineffective. Further, resistance traits can be spread between unrelated ... -
Reseptpliktige legemidler og samtidig bruk av lavdose naltrekson (LDN) hos pasienter med kronisk inflammatorisk tarmsykdom. En kvasieksperimentell reseptregisterstudie
(Master thesis; Mastergradsoppgave, 2017-05-15)BAKGRUNN: Naltrekson er en ikke-selektiv opioidantagonist som tradisjonelt brukes til å behandle opioid- og alkoholavhengighet. Lavdose naltrekson (LDN), 3-5 mg/dag, har senere blitt brukt som «off-label» tilleggsbehandling i flere autoimmune sykdommer, inkludert kronisk inflammatorisk tarmsykdom (IBD). FORMÅL: Formålet med denne studien er å undersøke om det er en assosiasjon mellom bruk av LDN og ... -
Etablering av et system for å studere funksjonelle konsekvenser av kreftspesifikke DDR2 mutasjoner
(Master thesis; Mastergradsoppgave, 2014-05-20)Discoidin domene reseptor 2 (DDR2) er en unik reseptor tyrosinkinase (RTK) som aktiveres av ulike typer kollagen. DDR2 er involvert i regulering av celledifferensiering, remodelering av ekstracellulær matriks, cellemigrasjon, og celleproliferasjon. Nye studier viser at DDR2 er mutert i flere kreftformer, og spesielt lungekreft. Konsekvensen av disse kreftspesifikke mutasjoner er i midlertidig ikke ... -
Melt processability of amorphous solid dispersions during hot-melt extrusion. Screening using vacuum compression moulding and evaluation by rheology and solid-state analysis
(Master thesis; Mastergradsoppgave, 2018-05-15)Soluplus is a suitable excipient for innovative manufacturing techniques such as hot-melt extrusion (HME). While Soluplus is useful for forming amorphous solid dispersions (ASD’s) during HME, the resulting extrudates are often stiff and brittle. In order to achieve suitable dosage forms, with optimal downstream processability, an efficient screening for suitable formulations is required. Vacuum ... -
A study of Fez1 and Fez2: Localization and knock-out
(Master thesis; Mastergradsoppgave, 2016-05-11)Autophagy is a fundamental cellular process where cell components get digested in autolysosomes and are recycled. Dysregulation of autophagy is involved in major diseases like cancer, neurodegeneration, inflammation and ischemia. In this thesis we have worked with fasciculation and elongation zeta (Fez) proteins, which are reported to inhibit autophagy. There are at least two mammalian Fez proteins, ... -
Legemiddelgjennomganger ved sykehjem i Nord-Gudbrandsdalen. Kartlegging av legemiddelbruk og legemiddelrelaterte problemer ved fire sykehjem i Nord-Gudbrandsdalen
(Master thesis; Mastergradsoppgave, 2017-05-15)Bakgrunn og hensikt: Sykehjemspasienter har mange sykdommer som ofte behandles medikamentelt. Polyfarmasi er derfor vanlig og har blitt assosiert med legemiddelrelaterte problemer (LRPer). Norske studier hvor de utførte legemiddelgjennomganger (LMGer) har vist et gjennomsnittlig antall LRPer hos sykehjemspasienter mellom 1,6-5,1. Overordnet hensikt med prosjektet var å belyse hvordan farmasøytisk ... -
Collateral sensitivity in clinical Escherichia coli isolates resistant to ciprofloxacin and/or mecillinam
(Master thesis; Mastergradsoppgave, 2017-05-16)The escalating emergence of AMR is a growing public health concern, and a result of the use and misuse of antibiotics since its introduction. To prevent the development of resistance and preserve the efficacy of antimicrobial agents, new treatment strategies is of utmost importance. One possible approach may be to take advantage of collateral sensitivity, a phenomenon where bacteria acquiring ... -
Bruk av reseptpliktige legemidler hos pasienter med hypotyreose eller Sjøgrens syndrom som starter med lavdose naltrekson (LDN)
(Master thesis; Mastergradsoppgave, 2017-05-15)De siste årene har Lavdose naltrekson (≤ 5 mg/dag) i økende grad blitt brukt som «off label» støttebehandling ved kroniske smerte, fibromyalgi, multippel sklerose, inflammatorisk tarmsykdom Sjøgrens syndrom, hypotyreose og andre autoimmune lidelser. Det er finnes ingen publiserte studier hvor det er undersøkt effekt av LDN ved behandling hos pasienter med hypotyreose eller Sjøgrens syndrom. Formålet ... -
Identifying signaling pathway responsible for SRC-3 serine 857 phosphorylation. A study in lung cancer cells
(Master thesis; Mastergradsoppgave, 2014-05-20)Signal transduction mediated by protein kinases and phosphatases is complex and highly coordinated. The mitogen activated protein kinases (MAPKs) are key components that transduce extracellular stimuli to biological responses by a three-tier module. The biological functions of steroid receptor coactivator-3 (SRC-3), a coactivator of nuclear hormone receptors and numerous transcription factors, is ... -
Administrasjonskostnader for ulike formuleringer av rituksimab og trastuzumab i norske helseforetak. En kvalitativ studie
(Master thesis; Mastergradsoppgave, 2019-05-15)Introduksjon: Kreftklinikken ved Oslo Universitetssykehus (OUS) har estimert administrasjonskostnader for intravenøs infusjon (IV) og subkutan injeksjon (SC) og Sykehusinnkjøp LIS har brukt disse estimatene for å vise at bruk av IV framfor SC av rituksimab og trastuzmab vil være mer kostnadseffektivt. Det er ukjent om disse estimatene er representative for andre helseforetak. Hensikt: Det primære ... -
Befolkningens kunnskap om antibiotika – en spørreundersøkelse blant apotekkunder
(Master thesis; Mastergradsoppgave, 2017-05-15)BAKGRUNN: Uhensiktsmessig og feilaktig bruk av antibiotika er en av de viktigste årsakene til fremveksten av resistente bakterier. Økt antibiotikakunnskap blant allmennheten kan bidra til å oppnå bedre behandlingsresultater og samtidig redusere resistensutvikling hos bakterier. Ett av målene fra Nasjonal strategi mot antibiotikaresistens 2015-2020 er å øke befolkningens kunnskapsnivå om riktig bruk ... -
Knowledge of antibiotics and antibiotic resistance among Norwegian pharmacy customers – a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-15)<p><i>Background</i>: Antibiotic resistance is a global health threat. Public knowledge is considered a prerequisite for appropriate use of antibiotics and limited spread of antibiotic resistance. Our aim was to examine the level of knowledge of antibiotics and antibiotic resistance among Norwegian pharmacy customers, and to assess to which degree beliefs, attitudes and sociodemographic factors are ... -
Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-10)DYRK1A is one of five members of the dual-specificity tyrosine (Y) phosphorylation-regulated kinase (DYRK) family. The DYRK1A gene is located in the Down syndrome critical region and regulates cellular processes related to proliferation and differentiation of neuronal progenitor cells during early development. This has focused research on its role in neuronal degenerative diseases, including ... -
The competitive edge of an invading specialist
(Journal article; Tidsskriftartikkel; Peer reviewed, 2001-08-01)Introduced species represent major threats to native and natural biodiversity. On the other hand, biologists may increase the understanding of ecological interactions by following communities during establishment of exotic species. Accordingly, feeding ecology and habitat use were studied in native whitefish (<i>Coregonus lavaretus</i>) and recently invading vendace (<i>C. albula</i>) in two lake ... -
Invasion-mediated changes in the population biology of a dimorphic whitefish Coregonus lavaretus population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2004-02-26)Population biology changes in native dimorphic whitefish <i>Coregonus lavaretus</i> were studied over a decade in the subarctic Pasvik watercourse, where large biotric changes occurred due to an invasion by vendace <i> C. albula</i>. Although initially recorded in the upstream part of the watercourse, where it is now the dominant pelagic species, the vendace subsequently also colonised the downstream ... -
Mimicking regional and fasted/fed state conditions in the intestine with the mucus-PVPA in vitro model: The impact of pH and simulated intestinal fluids on drug permeability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-27)Intestinal drug absorption following oral administration can be influenced by regional conditions (absorbing surface area, bacterial flora, motility, pH, mucus thickness) and food intake, all of which affect drug solubility and permeability. Therefore, it is crucial to assess the impact of these conditions on the drugability of drugs and formulations. In this study, the ability of the liposome-based ...
