Bakgrunn: Uoverensstemmelser (UOr) mellom legemiddellister i sykehus og hva pasientene faktisk tar av legemidler forekommer hyppig. Det kan være flere årsaker til dette, blant annet dårlig kommunikasjon mellom omsorgsnivå eller mellom helsepersonell og pasient. Problemet øker med økende antall legemidler. Helse Nord er i ferd med å innføre prosedyre for legemiddelsamstemming (LMS) for å sikre at ...

Bakgrunn: Systematiske legemiddelgjennomganger i tverrfaglig team kan være til hjelp for å identifisere potensielle og aktuelle legemiddelrelaterte problemer (LRP). Oslo kommune valgte i 2015 å prioritere legemiddelgjennomganger for psykisk utviklingshemmede, en gruppe mennesker som bruker mange legemidler. Dette er den første studien på legemiddelgjennomganger og identifisering av LRP blant psykisk ...

Abstract A size distribution between 200 and 300 nm and a high drug entrapment is desirable for liposomes intended for topical application. In an early phase of drug development, small batch sizes are also wanted. Dual Asymmetric Centrifugation (DAC) meets these requirement and was our method of choice. But, after successful production of a few DAC-liposome batches with drug entrapment of ...

Important compositional elements, including residues of herbicides, were investigated in commercial soy varieties grown within the same geographical area. These included genetically modified, conventional and organic soybeans. Feed made from these soybeans was subsequently fed to the model organism Daphnia magna, while measuring the fitness performance (survival, growth and reproduction) during the ...

The aim of this study was to develop a novel predictive medium-throughput screening method for drug permeability, with use of a tight barrier of liposomes on a filter support. To our knowledge no one has succeeded in depositing membrane barriers without the use of inert solvent such as hexadecane. The first part of the study involved development of a protocol for preparation of these barriers, which ...

Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability ...

In this study the integrity of the recently developed phospholipid vesicle-based permeability barrier in the presence of a variety of co-solvents and tensides has been investigated. Also included are studies of the influence of these additives on drug permeation and the effect of pH changes on the permeability of ionogenic drug compounds. Permeability experiments using the hydrophilic model ...

<p><i>Background - </i>Genetically modified glyphosate-tolerant cultivar varieties have been a commercial success widely known as Roundup Ready plants. As new glyphosate-tolerant varieties are introduced to satisfy agriculture demand, it is relevant to review the scientific evidence that documents the quality and safety of such biotechnology. Assessments of genetically modified glyphosate-tolerant ...

A paper reporting findings relevant to safety of the genetically modified (GM) maize NK603 and the herbicide Roundup (Séralini et al., Food Chem Toxicol. 50:4221–4231, 2012) was retracted against the wishes of the authors, and subsequently republished in another peer-reviewed journal (Séralini et al. Environ Sci Europe, doi:10.1186/s12302- 014-0014-5, 2014). These events exemplify a trend in which ...

We here report an experimentally verified binding mode for the known tripeptidomimetic CXCR4 antagonist KRH-1636 (1). A limited SAR study based on the three functionalities of 1 was first conducted, followed by site-directed mutagenesis studies. The receptor mapping showed that both the potency and affinity of 1 were dependent on the transmembrane residues His113, Asp171, Asp262, and His281 and also ...