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High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome

Permanent link
https://hdl.handle.net/10037/13297
DOI
https://doi.org/10.1128/AEM.01510-17
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Date
2017-09-22
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Guljamow, Arthur; Kreische, Marco; Ishida, Keishi; Liaimer, Anton; Altermark, Bjørn; Bähr, Lars; Hertweck, Christian; Dittmann, Elke
Abstract
Terrestrial symbiotic cyanobacteria of the genus Nostoc exhibit a large potential for the production of bioactive natural products of the nonribosomal peptide, polyketide, and ribosomal peptide classes, and yet most of the biosynthetic gene clusters are silent under conventional cultivation conditions. In the present study, we utilized a high-density cultivation approach recently developed for phototrophic bacteria to rapidly generate biomass of the filamentous bacteria up to a density of 400 g (wet weight)/liter. Unexpectedly, integrated transcriptional and metabolomics studies uncovered a major reprogramming of the secondary metabolome of two Nostoc strains at high culture density and a governing effect of extracellular signals in this process. The holistic approach enabled capturing and structural elucidation of novel variants of anabaenopeptin, including one congener with potent allelopathic activity against a strain isolated from the same habitat. The study provides a snapshot on the role of cell-type-specific expression for the formation of natural products in cyanobacteria.
Description
Source at https://doi.org/10.1128/AEM.01510-17.
Publisher
American Society for Microbiology
Citation
Guljamow, A., Kreische, M., Ishida, K., Liaimer, A., Altermark, B., Bähr, L., ... Dittmann, E. (2017). High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome. Applied and Environmental Microbiology, 83(23:e01510-17), 1-15. https://doi.org/10.1128/AEM.01510-17
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