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dc.contributor.authorvan Dalum, Jayme
dc.contributor.authorMelum, Vebjørn J.
dc.contributor.authorWood, Shona H.
dc.contributor.authorHazlerigg, David G.
dc.date.accessioned2020-01-22T15:11:52Z
dc.date.available2020-01-22T15:11:52Z
dc.date.issued2020-01-10
dc.description.abstractThis mini-review considers the phenomenon of maternal photoperiodic programming (MPP). In order to match neonatal development to environmental conditions at the time of birth, mammals use melatonin produced by the maternal pineal gland as a transplacental signal representing ambient photoperiod. Melatonin acts via receptors in the fetal pituitary gland, exerting actions on the developing medio-basal hypothalamus. Within this structure, a central role for specialized ependymal cells known as tanycytes has emerged, linking melatonin to control of hypothalamic thyroid metabolism and in turn to pup development. This review summarizes current knowledge of this programming mechanism, and its relevance in an eco-evolutionary context. Maternal photoperiodic programming emerges as a useful paradigm for understanding how <i>in utero</i> programing of hypothalamic function leads to life-long effects on growth, reproduction, health and disease in mammals, including humans.en_US
dc.identifier.citationvan Dalum M,, Melum VJ, Wood SH, Hazlerigg D. Maternal Photoperiodic Programming: Melatonin and Seasonal Synchronization Before Birth. Frontiers in Endocrinology. 2020en_US
dc.identifier.cristinIDFRIDAID 1777413
dc.identifier.doihttps://doi.org/10.3389/fendo.2019.00901
dc.identifier.issn1664-2392
dc.identifier.urihttps://hdl.handle.net/10037/17186
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.ispartofvan Dalum, M.J. (2022). Evolution of seasonal adaptations in voles - a physiological and genetic approach. (Doctoral thesis). <a href=https://hdl.handle.net/10037/24919>https://hdl.handle.net/10037/24919</a>.
dc.relation.journalFrontiers in Endocrinology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/?/Norway/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480en_US
dc.titleMaternal Photoperiodic Programming: Melatonin and Seasonal Synchronization Before Birthen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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