ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraaknorsk 
    • EnglishEnglish
    • norsknorsk
  • Administrasjon/UB
Vis innførsel 
  •   Hjem
  • Universitetsbiblioteket
  • Artikler, rapporter og annet (UB)
  • Vis innførsel
  •   Hjem
  • Universitetsbiblioteket
  • Artikler, rapporter og annet (UB)
  • Vis innførsel
JavaScript is disabled for your browser. Some features of this site may not work without it.

A novel ECG-biomarker for cardiac arrest during hypothermia

Permanent lenke
https://hdl.handle.net/10037/18276
DOI
https://doi.org/10.1186/s13049-020-00721-0
Thumbnail
Åpne
article.pdf (321.6Kb)
Publisert versjon (PDF)
Dato
2020-04-10
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Dietrichs, Erik Sveberg; Tveita, Torkjel; Myles, Rachel; Smith, Godfrey L
Sammendrag
Background - Treatment of arrhythmias evoked by accidental or therapeutic hypothermia and rewarming remains challenging. We aim to find an ECG-biomarker that can predict ventricular arrhythmias at temperatures occurring in therapeutic and accidental hypothermia.

Main body - Evaluation of ECG-data from accidental and therapeutic hypothermia patients and experimental data on ECG and ventricular fibrillation (VF) threshold in hypothermic New Zealand White Rabbits. VF threshold was measured in rabbit hearts cooled to moderate (31 °C) and severe (17 °C) hypothermia. QRS-interval divided by corrected QT-interval (QTc) was calculated at same temperatures. Clinical QRS/QTc data were obtained after a systematic literature review. Rabbit QRS/QTc values correlated with risk for VF (correlation coefficient: 0.97). Human QRS/QTc values from hypothermic patients, showed similar correlation with risk for ventricular fibrillation in the experimental data (correlation coefficient: 1.00).

Conclusions - These calculations indicate that QRS/QTc has potential as novel biomarker for predicting risk of hypothermia-induced cardiac arrest. Our findings apply both to victims of accidental hypothermia and to patients undergoing therapeutic hypothermia during surgery or after e.g. cardiac arrest.

Forlag
BMC
Sitering
Dietrichs ES, Tveita T, Myles R, Smith GL. A novel ECG-biomarker for cardiac arrest during hypothermia. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2020;28:27:1-3
Metadata
Vis full innførsel
Samlinger
  • Artikler, rapporter og annet (UB) [3251]
Copyright 2020 The Author(s)

Bla

Bla i hele MuninEnheter og samlingerForfatterlisteTittelDatoBla i denne samlingenForfatterlisteTittelDato
Logg inn

Statistikk

Antall visninger
UiT

Munin bygger på DSpace

UiT Norges Arktiske Universitet
Universitetsbiblioteket
uit.no/ub - munin@ub.uit.no

Tilgjengelighetserklæring