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Parametric Sensitivity of CSTBRs for Lactobacillus casei: Normalized Sensitivity Analysis

Permanent link
https://hdl.handle.net/10037/18734
DOI
https://doi.org/10.3390/chemengineering4020041
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Date
2020-06-18
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Das, Subhashis; Calay, Rajnish K; Chowdhury, Ranjana
Abstract
In this paper, a sensitivity analysis of a continuous stirred tank bioreactor (CSTBR) was conducted to determine a parametrically sensitive regime. The growth of a lactic acid bacterium, namely, Lactobacillus casei, in a pH-controlled CSTBR was considered as a process model. Normalized objective sensitivities of the minimum pH were determined with respect to input parameters. A generalized criterion for sensitivity was defined for determining the parametric range of three input variables, i.e., dilution rate base stream (θ), base concentration (R), and initial pH (pH0) for maintaining optimal pH range in the reactor. The system exhibits sensitive behavior for θ, R, and pH0, from 0.095 to 0.295, 0 to 0.865, and 4.42 to 4.77, respectively. The critical values of θ, R, and pH0 are 0.0195, 0.48, and 4.6, respectively. The mathematical model can also be used to determine a parametrically sensitive regime for other important parameters, namely, temperature, the concentration of metabolites, and other byproducts. The mathematical tool can also be used in bioreactor design and the improvement of control strategies.
Is part of
Das, S. (2021). Mathematical modelling of bioenergy systems for stability analysis and parametric sensitivity. (Doctoral thesis). https://hdl.handle.net/10037/20637
Publisher
MDPI
Citation
Das S, Calay RK, Chowdhury R. Parametric Sensitivity of CSTBRs for Lactobacillus casei: Normalized Sensitivity Analysis. ChemEngineering. 2020;4(2):41
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