Blar i forfatter Artikler, rapporter og annet (kjemi) "De Santi, Concetta"

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    • Biochemical characterization of a family 15 carbohydrate esterase from a bacterial marine Arctic metagenome 

      De Santi, Concetta; Willassen, Nils Peder; Williamson, Adele Kim (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Background The glucuronoyl esterase enzymes of wood-degrading fungi (Carbohydrate Esterase family 15; CE15) form part of the hemicellulolytic and cellulolytic enzyme systems that break down plant biomass, and have possible applications in biotechnology. Homologous enzymes are predicted in the genomes of several bacteria, however these have been much less studied than their fungal counterparts. ...

    • Bioprospecting around Arctic islands: Marine bacteria as rich source of biocatalysts 

      De Santi, Concetta; Altermark, Bjørn; de Pascale, Donatella; Willassen, Nils Peder (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-11)
      We have investigated the biotechnological potential of Arctic marine bacteria for their ability to produce a broad spectrum of cold-active enzymes. Marine bacteria exhibiting these features are of great interest for both fundamental research and industrial applications. Macrobiota water and sediment samples have been collected during 2010 and 2011expeditions around the Lofoten and Svalbard islands. ...

    • Characterization of a cold-active and salt tolerant esterase identified by functional screening of Arctic metagenomic libraries 

      De Santi, Concetta; Altermark, Bjørn; Pierechod, Marcin Miroslaw; Ambrosino, Luca; de Pascale, Donatella; Willassen, Nils Peder (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-19)
      Background: The use of metagenomics in enzyme discovery constitutes a powerful approach to access to genomes of unculturable community of microorganisms and isolate novel valuable biocatalysts for use in a wide range of biotechnological and pharmaceutical fields. Results: Here we present a novel esterase gene (lip3) identified by functional screening of three fosmid metagenomic libraries, ...

    • Closely-related Photobacterium strains comprise the majority of bacteria in the gut of migrating Atlantic cod (Gadus morhua) 

      Le Doujet, Typhaine; De Santi, Concetta; Klemetsen, Terje; Hjerde, Erik; Willassen, Nils Peder; Haugen, Peik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-17)
      <p><i>Background - </i>The population of Atlantic cod (<i>Gadus morhua</i>), also known as Northeast Arctic cod, migrating Atlantic cod, or simply “skrei,” lives mainly in the Barents Sea and Svalbard waters and migrates in annual cycles to the Norwegian coast in order to spawn eggs during late winter. It is the world’s largest population of Atlantic cod, and the population is distinct from the ...

    • Complete genome sequence of Halomonas sp. R5-57 

      Williamson, Adele Kim; De Santi, Concetta; Altermark, Bjørn; Karlsen, Christian; Hjerde, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      The marine Arctic isolate Halomonas sp. R5-57 was sequenced as part of a bioprospecting project which aims to discover novel enzymes and organisms from low-temperature environments, with potential uses in biotechnological applications. Phenotypically, Halomonas sp. R5-57 exhibits high salt tolerance over a wide range of temperatures and has extra-cellular hydrolytic activities with several ...

    • High quality draft genome sequence of Streptomyces sp. strain AW19M42 isolated from a sea squirt in Northern Norway 

      Bjerga, Gro Elin Kjæreng; Hjerde, Erik; De Santi, Concetta; Williamson, Adele Kim; Smalås, Arne O.; Willassen, Nils Peder; Altermark, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Structural insight into a CE15 esterase from the marine bacterial metagenome 

      De Santi, Concetta; Gani, Osman A. B. S. M.; Helland, Ronny; Williamson, Adele Kim (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-08)
      The family 15 carbohydrate esterase (CE15) MZ0003, which derives from a marine Arctic metagenome, has a broader substrate scope than other members of this family. Here we report the crystal structure of MZ0003, which reveals that residues comprising the catalytic triad differ from previously-characterized fungal homologs, and resolves three large loop regions that are unique to this bacterial ...