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dc.contributor.authorBerg, Lars Martin
dc.contributor.authorAnkjell, Torun Karina Solheim
dc.contributor.authorSun, Yi-Qian
dc.contributor.authorTrovik, Tordis A
dc.contributor.authorRikardsen, Oddveig G
dc.contributor.authorSjögren, Anders
dc.contributor.authorMoen, Ketil
dc.contributor.authorHellem, Sølve
dc.contributor.authorBugten, Vegard
dc.date.accessioned2020-08-19T14:39:59Z
dc.date.available2020-08-19T14:39:59Z
dc.date.issued2020-07-01
dc.description.abstractIn this randomized controlled trial, patients with non-severe obstructive sleep apnea (OSA) were treated with continuous positive airway pressure (CPAP) or a twin block mandibular advancement splint (MAS). The primary objective was to compare how CPAP and MAS treatments change the health-related quality of life (HRQoL) and self-reported sleep quality of patients after 12 months of treatment. In total, 104 patients were recruited: 55 were allocated to the CPAP-treatment group and 49 to the MAS-treatment group. We used the SF36 questionnaire to evaluate HRQoL and the Pittsburgh Sleep Quality Index (PSQI) to evaluate sleep quality. All patients were included in the intention-to-treat analyses. These analyses showed improvements in the SF36 physical component score (from 48.8 ± 7.6 at baseline to 50.5 ± 8.0 at follow-up, <i>p</i> = 0.03) in the CPAP treatment group and in the mental component score (from 44.9 ± 12.1 to 49.3 ± 9.2, <i>p</i> = 0.009) in the MAS treatment group. The PSQI global score improved in both the CPAP (from 7.7 ± 3.5 to 6.6 ± 2.9, <i>p</i> = 0.006) and the MAS (8.0 ± 3.1 to 6.1 ± 2.6, <i>p</i> < 0.001) treatment group. No difference was found between treatment groups in any of the SF36 scores or PSQI global score at the final follow-up (<i>p</i> > 0.05) in any analysis. The improvement in the SF36 vitality domain moderately correlated to the improvement in the PSQI global score in both groups (CPAP: |<i>r</i>| = 0.47, p < 0.001; MAS: |<i>r</i>| = 0.36, p = 0.01). In the MAS treatment group, we also found a weak correlation between improvements in the SF36 mental component score and PSQI global score (|<i>r</i>| = 0.28, <i>p</i> = 0.05). In conclusion, CPAP and MAS treatments lead to similar improvements in the HRQoL and self-reported sleep quality in non-severe OSA. Improvements in aspects of HRQoL seems to be moderately correlated to the self-reported sleep quality in both CPAP and MAS treatment.en_US
dc.identifier.citationBerg LM, Ankjell TK, Sun YQ, Trovik TA, Rikardsen O, Sjögren APG, Moen K, Hellem S, Bugten V. Health-related quality of life and sleep quality after 12 months of treatment in non-severe obstructive sleep apnea: A randomized clinical trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints. International Journal of Otolaryngology. 2020en_US
dc.identifier.cristinIDFRIDAID 1818683
dc.identifier.doi10.1155/2020/2856460
dc.identifier.issn1687-9201
dc.identifier.issn1687-921X
dc.identifier.urihttps://hdl.handle.net/10037/19060
dc.language.isoengen_US
dc.publisherHindawien_US
dc.relation.ispartofBerg, L.M. (2022). Treatment success with continuous positive airway pressure or mandibular advancement splints in non-severe obstructive sleep apnea: A randomized controlled clinical trial on sleep quality, health-related quality of life and clinical predictors of treatment success. (Doctoral thesis). <a href=https://hdl.handle.net/10037/24049>https://hdl.handle.net/10037/24049</a>.
dc.relation.journalInternational Journal of Otolaryngology
dc.relation.urihttps://doi.org/10.1155/2020/2856460
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Otorhinolaryngologi: 755en_US
dc.subjectVDP::Midical sciences: 700::Clinical medical sciences: 750::Otolaryngology: 755en_US
dc.subjectSøvnforstyrrelser / søvnproblemer / søvnbesvær / Sleep Disordersen_US
dc.titleHealth-related quality of life and sleep quality after 12 months of treatment in non-severe obstructive sleep apnea: A randomized clinical trial with Continuous Positive Airway Pressure and Mandibular Advancement Splintsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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