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Diversified regulation of circadian clock gene expression following whole genome duplication

Permanent link
https://hdl.handle.net/10037/20373
DOI
https://doi.org/10.1371/journal.pgen.1009097
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Date
2020-10-08
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
West, Alexander Christopher; Iversen, Marianne; Jørgensen, Even Hjalmar; Sandve, Simen Rød; Hazlerigg, David; Wood, Shona Hiedi
Abstract
Across taxa, circadian control of physiology and behavior arises from cell-autonomous oscillations in gene expression, governed by a networks of so-called ‘clock genes’, collectively forming transcription-translation feedback loops. In modern vertebrates, these networks contain multiple copies of clock gene family members, which arose through whole genome duplication (WGD) events during evolutionary history. It remains unclear to what extent multiple copies of clock gene family members are functionally redundant or have allowed for functional diversification. We addressed this problem through an analysis of clock gene expression in the Atlantic salmon, a representative of the salmonids, a group which has undergone at least 4 rounds of WGD since the base of the vertebrate lineage, giving an unusually large complement of clock genes. By comparing expression patterns across multiple tissues, and during development, we present evidence for gene- and tissue-specific divergence in expression patterns, consistent with functional diversification of clock gene duplicates. In contrast to mammals, we found no evidence for coupling between cortisol and circadian gene expression, but cortisol mediated non-circadian regulated expression of a subset of clock genes in the salmon gill was evident. This regulation is linked to changes in gill function necessary for the transition from fresh- to sea-water in anadromous fish. Overall, this analysis emphasises the potential for a richly diversified clock gene network to serve a mixture of circadian and non-circadian functions in vertebrate groups with complex genomes.
Is part of
Iversen, M. (2021). Photoperiodic history-dependent preadaptation of the smolting gill. Novel players and SW immediate response as markers of growth and welfare. (Doctoral thesis). https://hdl.handle.net/10037/20678
Publisher
Public Library of Science
Citation
West AC, Iversen M, Jørgensen E H, Sandve SR, Hazlerigg D, Wood SH. Diversified regulation of circadian clock gene expression following whole genome duplication. PLoS Genetics. 2020
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